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This medicine is an estrogen and progestin combination used to reduce menopausal symptoms. It is also used to prevent osteoporosis. This medicine may also be used to treat other conditions as determined by your doctor. There are several medications (e.g. raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen/progestin HRT for osteoporosis. If you have other medical conditions as well and are prescribed estrogen/progestin HRT for more than one condition, consult your doctor about your treatment plan and its options.

Follow the directions for using this medicine provided by your doctor. THIS MEDICINE COMES with a patient information leaflet. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have before using this medicine. This medicine should be used for the shortest possible length of time so you obtain the benefits and minimize the chance of serious side effects from long-term therapy. Consult your doctor for more details. TRY TO TAKE THIS MEDICINE at the same time every day. STORE THIS MEDICINE at room temperature between 59 and 86 degrees F (15 and 30 degrees C), away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NO

KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. YOU SHOULD PERFORM REGULAR self-examinations of your breasts. If you have any questions about how to do this, ask your doctor, nurse, or pharmacist. SMOKING WHILE USING THIS MEDICINE may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tas

ESTRADIOL (ess-tra-DYE-ole) and NORETHINDRONE (nor-eth-IN-drone) ACETATE