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Estrogel 0.06% Gel (Estradiol) comes in an 80G pack size. This medication is used to reduce hot flashes or vaginal dryness. It is a female hormone (estrogen) and is given to women who no longer produce the proper amount after the change in life (menopause). If you are only being treated for vaginal menopause symptoms, products such as vaginal creams, tablets, or rings should be considered before products absorbed through the skin.