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Antabuse (Disulfiram)

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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Antabuse, also known by its generic name Disulfiram, is a medication primarily used to treat chronic alcoholism. It works by creating an unpleasant reaction in the body when alcohol is consumed, thereby discouraging individuals from drinking. This aversion therapy is particularly helpful for those who have difficulty abstaining from alcohol due to addiction or dependency.

Before you buy Antabuse, it is crucial that you talk to your healthcare provider about potential side effects and affordability.

Fact Table
Formula C10H20N2S4
License FDA approved
Bioavailability 70-90%
Legal status Prescription drug
Chemical Name Disulfiram
Elimination half-life 60-120 hours
Dosage (Strength) 250mg, 500mg
Pregnancy Consult doctor
Brands Antabuse
Protein binding 97-99%
PubChem CID 3117
MedlinePlus a682602
ATC code N07BB01
DrugBank DB00822
KEGG D07821
Routes of administration By mouth

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Antabuse dosage should be taken exactly as prescribed by a healthcare professional. It is typically taken once daily, preferably in the morning to help establish a routine. It is crucial to avoid consuming any alcohol while taking Antabuse and for at least 14 days after discontinuing the medication. Failure to adhere to this guideline can result in severe adverse reactions. If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule resumed. It is important not to take double doses to make up for a missed one.


The active ingredient in Antabuse is Disulfiram.


Antabuse or Antabuse generic is not suitable for everyone, and certain precautions should be taken before starting this medication. Individuals with a history of severe heart disease, psychosis, severe liver disease, or sensitivity to thiuram derivatives should avoid taking Antabuse.

Pregnant or breastfeeding women should consult their healthcare provider before using this medication, as its safety during pregnancy and lactation has not been established.

It is essential to inform the prescribing healthcare professional about any existing medical conditions, allergies, or medications being taken to ensure Antabuse is safe and appropriate for use.


Antabuse can interact with various medications and substances, potentially leading to adverse effects or reduced efficacy. It is crucial to inform the healthcare provider about all medications, including prescription, over the counter, herbal supplements, and recreational drugs, before starting Antabuse. Drugs that may interact with Antabuse include but are not limited to alcohol-containing products, certain medications used to treat mental health conditions, such as antidepressants, antipsychotics, and sedatives, drugs metabolized by the liver, warfarin, and other blood thinners.

Side Effects

Like all medications, Antabuse can cause side effects, although not everyone experiences them. Common side effects may include:

  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Drowsiness
  • Metallic taste in the mouth
  • Skin rash or itching

Frequently Asked Questions about Antabuse (Disulfiram)

What is Antabuse (Disulfiram)?

Antabuse is a prescription medication used to help individuals maintain sobriety from alcohol.

How does Antabuse work?

Antabuse causes an unpleasant reaction when even small amounts of alcohol are consumed.

Who should take Antabuse?

Antabuse is intended for individuals who are motivated to stop drinking and are committed to a treatment program.

What are the common side effects of Antabuse?

Common side effects include drowsiness, fatigue, headache, and metallic taste.

Can Antabuse be taken with other medications?

It's crucial to inform your doctor about all other medications you're taking, as some interactions may occur.

How long does Antabuse stay in your system?

The effects of Antabuse can last for several days after the last dose.

Are there any food or drink restrictions while taking Antabuse?

It's essential to avoid all forms of alcohol, including those found in foods, medications, and personal care products.

What happens if I accidentally consume alcohol while on Antabuse?

An unpleasant reaction including flushing, nausea, vomiting, and headache may occur. Seek medical attention if needed.

Can I stop taking Antabuse abruptly?

Discontinue Antabuse only under the guidance of your doctor.

Where can I get more information about Antabuse?

Consult your doctor or pharmacist for detailed information regarding Antabuse.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.