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Apoquel (Oclacitinib)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Apoquel is a prescription drug that provides fast and effective relief from itching and inflammation in dogs facing allergic and atopic dermatitis. It specifically addresses the root causes of itching and swelling in dogs, offering rapid relief without the use of steroids. This medication is appropriate for dogs of any breed or size who are at least 12 months old, making it a versatile choice for pet owners looking to ease their dog's discomfort. Before you buy Apoquel, consult with your veterinarian about the efficacy and Apoquel cost.

Fact Table
Formula C15H23N5O2S
License US FDA
Bioavailability 89%
Legal status OTC/Rx
Chemical Name Oclacitinib
Elimination half-life 3.1–5.2 hours
Dosage (Strength) 3.6mg, 5.4mg, 16mg
Pregnancy Not applicable
Brands Apoquel
Protein binding 66.3–69.7%
PubChem CID 44631938
MedlinePlus Not Assigned Yet
ChEBI Not Assigned Yet
ATC code QD11AH90
DrugBank DB11441
KEGG D10141t
Routes of administration By mouth

Buy Apoquel (Oclacitinib) online from online Canadian Pharmacy |


Form: Available in tablet or chewable form.

Strengths: Comes in 3.6 mg, 5.4 mg, and 16 mg.

Starting Dose: Typically, 0.4 to 0.6 mg/kg, administered twice daily for the first 14 days.

Maintenance Dose: 0.4 to 0.6 mg/kg, taken once daily.

Dosage Determination: Exact dosage to be set by your veterinarian.

Administration: Can be taken with or without food.


Active Ingredient: Oclacitinib.


Apoquel for dogs is a prescription-only medication and should be used strictly under a veterinarian's guidance.

It is specifically designed for dogs and must not be given to cats or other animals.

Consult your veterinarian before using Apoquel if your dog is pregnant, nursing, or if there's a possibility of pregnancy.

Apoquel works by dampening the immune response to itch and inflammation, which, while effective in treating allergies, may also lower the body's capacity to fight infections.

If your dog needs long-term Apoquel therapy, your vet will closely monitor for any potential side effects, including changes in bloodwork or organ function.


Apoquel is typically well-tolerated, but it's crucial to be aware of possible drug interactions, such as corticosteroids, other Immunosuppressants, cyclosporine, digoxin, and other medications. Your vet will carefully assess these interactions when planning your dog's treatment regimen. Do not alter your dog's medication without consulting your veterinarian.

Side Effects

While Apoquel is generally safe and well-tolerated, some dogs may experience side effects, which can include vomiting, diarrhea, lethargy, reduced appetite, skin infections and ear infections.

Frequently Asked Questions about Apoquel (Oclacitinib) for Dogs

What is Apoquel (Oclacitinib) used for in dogs?

Apoquel is primarily used to treat itching and inflammation associated with allergic skin disease in dogs, including atopic dermatitis.

How does Apoquel work?

Apoquel works by selectively inhibiting certain cytokines (Janus kinase enzymes) involved in the allergic response, thus reducing itching and inflammation.

How quickly does Apoquel start to work?

Apoquel typically begins to relieve itching within 4 to 24 hours of the first dose.

Can Apoquel be used long-term?

Apoquel can be used for both short-term relief and long-term management of allergic skin conditions, but long-term use should be monitored by a veterinarian.

Are there any side effects of Apoquel?

Common side effects may include vomiting, diarrhea, and decreased appetite. Less commonly, more severe side effects like immune suppression can occur.

Is Apoquel safe for all dogs?

Apoquel is generally safe for most dogs over 12 months of age. However, it should not be used in dogs with severe infections or in breeding, pregnant, or lactating dogs.

Can Apoquel be given with other medications?

Apoquel can be given with some other medications, but it's important to consult with a veterinarian as it may interact with certain drugs.

How should Apoquel be administered?

Apoquel is administered orally, typically once or twice daily as prescribed by a veterinarian.

What should I do if I miss a dose of Apoquel?

If a dose is missed, give it as soon as you remember, but if it's close to the time for the next dose, skip the missed dose and resume the regular schedule.

How should Apoquel be stored?

Apoquel should be stored at room temperature, away from moisture and light, and kept out of reach of children and pets.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.