Apoquel (Oclacitinib)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C15H23N5O2S |
| License | US FDA |
| Bioavailability | 89% |
| Legal status | OTC/Rx |
| Chemical Name | Oclacitinib |
| Elimination half-life | 3.1–5.2 hours |
| Dosage (Strength) | 3.6mg, 5.4mg, 16mg |
| Pregnancy | Not applicable |
| Brands | Apoquel |
| Protein binding | 66.3–69.7% |
| PubChem CID | 44631938 |
| MedlinePlus | Not Assigned Yet |
| ChEBI | Not Assigned Yet |
| ATC code | QD11AH90 |
| DrugBank | DB11441 |
| KEGG | D10141t |
| Routes of administration | By mouth |
Apoquel is a prescription drug that provides fast and effective relief from itching and inflammation in dogs facing allergic and atopic dermatitis. It specifically addresses the root causes of itching and swelling in dogs, offering rapid relief without the use of steroids. This medication is appropriate for dogs of any breed or size who are at least 12 months old, making it a versatile choice for pet owners looking to ease their dog's discomfort. Before you buy Apoquel, consult with your veterinarian about the efficacy and Apoquel cost.
Directions
Form: Available in tablet or chewable form.
Strengths: Comes in 3.6 mg, 5.4 mg, and 16 mg.
Starting Dose: Typically, 0.4 to 0.6 mg/kg, administered twice daily for the first 14 days.
Maintenance Dose: 0.4 to 0.6 mg/kg, taken once daily.
Dosage Determination: Exact dosage to be set by your veterinarian.
Administration: Can be taken with or without food.
Ingredients
Active Ingredient: Oclacitinib.
Cautions
Apoquel for dogs is a prescription-only medication and should be used strictly under a veterinarian's guidance.
It is specifically designed for dogs and must not be given to cats or other animals.
Consult your veterinarian before using Apoquel if your dog is pregnant, nursing, or if there's a possibility of pregnancy.
Apoquel works by dampening the immune response to itch and inflammation, which, while effective in treating allergies, may also lower the body's capacity to fight infections.
If your dog needs long-term Apoquel therapy, your vet will closely monitor for any potential side effects, including changes in bloodwork or organ function.
Interactions
Apoquel is typically well-tolerated, but it's crucial to be aware of possible drug interactions, such as corticosteroids, other Immunosuppressants, cyclosporine, digoxin, and other medications. Your vet will carefully assess these interactions when planning your dog's treatment regimen. Do not alter your dog's medication without consulting your veterinarian.
Side Effects
While Apoquel is generally safe and well-tolerated, some dogs may experience side effects, which can include vomiting, diarrhea, lethargy, reduced appetite, skin infections and ear infections.
Frequently Asked Questions about Apoquel (Oclacitinib) for Dogs
What is Apoquel (Oclacitinib) used for in dogs?
Apoquel is primarily used to treat itching and inflammation associated with allergic skin disease in dogs, including atopic dermatitis.
How does Apoquel work?
Apoquel works by selectively inhibiting certain cytokines (Janus kinase enzymes) involved in the allergic response, thus reducing itching and inflammation.
How quickly does Apoquel start to work?
Apoquel typically begins to relieve itching within 4 to 24 hours of the first dose.
Can Apoquel be used long-term?
Apoquel can be used for both short-term relief and long-term management of allergic skin conditions, but long-term use should be monitored by a veterinarian.
Are there any side effects of Apoquel?
Common side effects may include vomiting, diarrhea, and decreased appetite. Less commonly, more severe side effects like immune suppression can occur.
Is Apoquel safe for all dogs?
Apoquel is generally safe for most dogs over 12 months of age. However, it should not be used in dogs with severe infections or in breeding, pregnant, or lactating dogs.
Can Apoquel be given with other medications?
Apoquel can be given with some other medications, but it's important to consult with a veterinarian as it may interact with certain drugs.
How should Apoquel be administered?
Apoquel is administered orally, typically once or twice daily as prescribed by a veterinarian.
What should I do if I miss a dose of Apoquel?
If a dose is missed, give it as soon as you remember, but if it's close to the time for the next dose, skip the missed dose and resume the regular schedule.
How should Apoquel be stored?
Apoquel should be stored at room temperature, away from moisture and light, and kept out of reach of children and pets.
