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Azulfidine EN (Sulfasalazine) Delayed Release

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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Azulfidine EN refers to a medication called sulfasalazine enteric-coated tablets. It is an oral medication used for the treatment of inflammatory bowel disease such as ulcerative colitis and rheumatoid arthritis. Sulfasalazine works by reducing inflammation in the body, specifically in the gastrointestinal tract for conditions like ulcerative colitis. The enteric-coated tablets are designed to pass through the stomach and dissolve in the intestines, where the medication is released.

Fact Table
Formula C18H14N4O5S
License FDA-approved
Bioavailability Less than 15%
Legal status Prescription drug
Chemical Name Sulfasalazine
Elimination half-life 5-10 hours
Dosage (Strength) 500mg
Pregnancy Consult healthcare provider
Brands Azulfidine
Protein binding More than 99.3%
PubChem CID 5339
MedlinePlus a682204
ChEBI 9334
ATC code A07EC01
DrugBank DB00795
KEGG D00448
Routes of administration By mouth

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To ensure optimal absorption, take Azulfidine EN tabs 500 mg orally after meals with a full glass of water or as instructed by your doctor.

Your doctor may recommend a gradual increase in dosage when starting treatment to reduce the likelihood of stomach discomfort. The specific dosage is determined based on your medical condition and how you respond to the therapy. For children, the dosage is also influenced by their weight.

If you are prescribed delayed-release tablets, make sure to swallow them whole without crushing, chewing, or breaking them. Breaking the tablets can increase the chance of stomach upset.

Drink plenty of fluids while taking this medication to prevent kidney stone formation unless your doctor advises otherwise.

Take this medication at the same time every day to maximize its benefits.


The Active Ingredient in Azulfidine EN is Sulfasalazine.


Inform your doctor about your medical history and allergies if you have any.

This medication may cause dizziness. Avoid driving, operating machinery, or performing tasks that require alertness until you can do so safely.

Limit alcohol consumption. If you use cannabis, discuss it with your doctor.

Use caution in the sun as this medication can increase sensitivity. Limit sun exposure.

Children and teenagers under 18 years old should avoid aspirin or aspirin-related medications if they have chickenpox, flu, undiagnosed illness, or have recently received a live virus vaccine, due to the risk of Reye's syndrome. Consult a doctor for more information.

This medication may temporarily affect male fertility. Consult your doctor for more details.

During pregnancy, it is advisable to use this medication only when it is deemed necessary.

Before breastfeeding, consult your doctor as this medication can pass into breast milk and potentially cause undesirable effects in nursing infants.


Azulfidine EN tabs can have negative drug interactions with digoxin, folic acid, methenamine, PABA taken by mouth. It is important to maintain a comprehensive list of all the products you are using, including prescription medications, over-the-counter drugs, and herbal products. Share this list with your doctor.

Side Effects

The most common side effects of Azulfidine EN tabs include upset stomach, nausea or vomiting, loss of appetite, headache, dizziness, rash, or skin reactions, yellowing of the skin or eyes, changes in urine color (orange-yellow), and allergic reactions, such as hives, itching, or swelling. Before you buy Azulfidine EN, consult your doctor or pharmacist for more detailed and personalized information regarding the potential side effects of Azulfidine EN.

Frequently Asked Questions about Azulfidine EN

What is Azulfidine used for?

Azulfidine is a medication used to treat certain inflammatory conditions, particularly inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.

What are the side effects of Azulfidine EN tabs?

Common side effects of Azulfidine EN tabs include nausea, vomiting, loss of appetite, headache, dizziness, tiredness, and changes in skin or urine color.

Is sulfasalazine good for your liver?

Sulfasalazine, the active ingredient in Azulfidine, can affect liver function in some individuals. It is important to monitor liver function regularly while taking sulfasalazine, as it can cause liver damage in rare cases.

How long does it take for Azulfidine to work?

The time it takes for Azulfidine to work can vary from person to person. In general, it may take several weeks to a few months to see the full effects of the medication.

Is Azulfidine an antibiotic?

No, Azulfidine is not an antibiotic. It is a medication that belongs to a class of drugs known as disease-modifying anti-rheumatic drugs (DMARDs).

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.