Berberine
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C20H18NO4+ |
| License | Non-prescription (dietary supplement) |
| Bioavailability | Low (poorly absorbed) |
| Legal status | Over-the-counter (dietary supplement) |
| Chemical Name | Berberine |
| Elimination half-life | ~4 hours |
| Dosage (Strength) | Typically 500 mg per dose (varies based on the product) |
| Pregnancy | Not recommended (consult healthcare provider) |
| Brands | Various dietary supplement brands |
| Protein binding | Moderate to high |
| PubChem CID | 2353 |
| MedlinePlus | Not listed specifically |
| ChEBI | CHEBI:2338 |
| ATC code | Not available |
| DrugBank | DB04113 |
| KEGG | D07445 |
| Routes of administration | Oral (capsules or tablets) |
Berberine is a natural compound extracted from several plants, including a group known as Berberis. Traditionally used in Chinese and Ayurvedic medicine for its anti-inflammatory and antimicrobial properties. The wide array of berberine uses includes improving cardiovascular health, managing diabetes, and supporting gastrointestinal function.
Before you buy Berberine, it is crucial that you talk to your healthcare provider about its effectiveness and potential side effects.
Directions
Take one capsule of Berberine 500 mg with a meal, up to three times daily, consistently for optimal results. Keep the bottle closed tightly and store it in a cool, dry place away from sunlight. Keep out of reach of children.
Ingredients
Each capsule contains: Berberine Hydrochloride.
Cautions
Not recommended for children under 18 years of age unless directed by a healthcare professional.
If you are pregnant or nursing, talk to your healthcare provider before using this product.
If you have a medical condition, particularly a history of low blood sugar levels or blood pressure, consult your doctor before use.
Discontinue use at least two weeks prior to scheduled surgery to avoid any potential interactions with anesthesia or post-operative complications.
Interactions
Berberine may interact with various medications and substances:
Diabetes Medication: Berberine can potentiate the effects of blood sugar-lowering drugs, which may require a dosage adjustment of your medication.
Antibiotics: It may alter the effectiveness of certain antibiotics, especially those that also affect the gut flora.
Cyclosporine: Berberine can decrease the metabolism and increase the effects of cyclosporine, necessitating close monitoring by a healthcare provider.
Always discuss with your healthcare provider any supplements or medications you are taking to avoid potential interactions.
Side Effects
While Berberine is well-tolerated, some users may experience mild side effects, especially when beginning treatment. Common side effects include:
- Digestive issues
- Headaches
- Low blood sugar
Frequently Asked Questions about Imcivree (Setmelanotide)
What is Imcivree?
Imcivree is the brand name for setmelanotide, a medication that targets the melanocortin 4 receptor (MC4R) pathway. It is used to treat obesity due to certain genetic conditions.
What is Imcivree used for?
Imcivree is used to manage obesity in individuals with specific genetic conditions, such as POMC (proopiomelanocortin) deficiency, PCSK1 (proprotein convertase subtilisin/kexin type 1) deficiency, and LEPR (leptin receptor) deficiency. These genetic conditions lead to severe obesity from an early age.
How does Imcivree work?
Imcivree works by activating the MC4R pathway in the brain, which helps regulate hunger and energy expenditure. By stimulating this pathway, the drug can reduce hunger and promote weight loss in individuals with genetic conditions affecting this pathway.
What are the results of Imcivree?
Clinical trials have shown that Imcivree can lead to significant weight loss in individuals with the specified genetic conditions. Patients have experienced reductions in body weight, improvements in hunger control, and better overall health outcomes.
Is Imcivree FDA approved?
Yes, Imcivree is approved by the U.S. Food and Drug Administration (FDA) for the treatment of obesity due to POMC, PCSK1, and LEPR deficiencies.
Can anyone take Imcivree?
No, Imcivree is specifically approved for use in individuals with genetic conditions such as POMC, PCSK1, and LEPR deficiencies. It is not intended for use in the general population or for individuals with obesity not related to these genetic conditions.
How to inject Imcivree?
Imcivree is administered via subcutaneous injection. Patients or caregivers are typically trained by healthcare professionals on how to properly prepare and inject the medication. It is usually injected into the abdomen, thigh, or upper arm.
What are the side effects of Imcivree?
Common side effects of Imcivree include injection site reactions, skin hyperpigmentation, nausea, headache, and fatigue. Some patients may experience changes in skin color, particularly in areas exposed to sunlight.
How often do you take Imcivree?
Imcivree is typically administered once daily. The exact dosing schedule should be determined by a healthcare provider based on the patient's individual needs and response to the treatment.
What are the adverse events of Setmelanotide?
Adverse events associated with setmelanotide (Imcivree) can include injection site reactions, skin hyperpigmentation, nausea, vomiting, headache, and fatigue. In rare cases, more serious adverse events such as depression, suicidal ideation, and hypersensitivity reactions have been reported. It's important for patients to be monitored regularly by their healthcare provider while on this medication.
