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Duac (Clindamycin phosphate, benzoyl peroxide)

Also Known as Clindoxyl

Prescription requiredOnly Available By Prescription
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Duac is a prescription medication specifically designed for the treatment of acne. It is applied topically in the form of a gel and effectively reduces the severity of acne symptoms. The medication contains an antibiotic component that works by inhibiting the growth of bacteria responsible for causing acne.

Additionally, Duac incorporates Benzoyl Peroxide, which acts as both an antibiotic and an oil-reducing agent. By regulating oil production, helps prevent pores from becoming easily clogged and reduces the formation of blackheads on the skin.

Fact Table
Formula Clindamycin Phosphate: C18H34ClN2O8PS, Benzoyl Peroxide: C14H10O4
License FDA Approved
Bioavailability Clindamycin: Not significantly absorbed, Benzoyl Peroxide: Minimal systemic absorption
Legal status US FDA, US DailyMed, EU EMA
Chemical Name Clindamycin phosphate / benzoyl peroxide
Elimination half-life Clindamycin: ~2.5 hours, Benzoyl Peroxide: Rapidly converted to benzoic acid
Dosage (Strength) 1% Clindamycin, 5% Benzoyl Peroxide
Pregnancy consult a healthcare provider
Brands Duac
Protein binding Clindamycin: 94%
PubChem CID Clindamycin Phosphate: 446556, Benzoyl Peroxide: 7187
MedlinePlus Not specific to combination
ChEBI Clindamycin Phosphate: CHEBI:3645, Benzoyl Peroxide: CHEBI:32036
ATC code D10AF51
DrugBank Clindamycin Phosphate: DB01190, Benzoyl Peroxide: DB09499
KEGG Clindamycin Phosphate: D01073, Benzoyl Peroxide: D03093
Routes of administration Topical

Buy Duac (Clindamycin phosphate, benzoyl peroxide) online from online Canadian Pharmacy |


Before applying Duac topical gel, cleanse the affected skin and ensure it is dry

Apply this gel once a day

Carefully apply a thin layer of the medication to the areas of the skin that are affected

Remember to wash your hands both before and after applying the medication


Clindamycin Phosphate and Benzoyl Peroxide are the active ingredients in Duac acne gel.


When using Duac acne gel, it is important to avoid applying it to the eyes, mouth, or nostrils.

Refrain from using on broken skin.

The gel should not be applied more frequently than once a day.

Before you buy Duac gel, inform your doctor about any history of enteritis, ulcerative colitis, or difficile-associated diarrhea.

Protect your skin during treatment, it is recommended to use sunscreen or keep the treated skin away from direct sunlight.

Duac is known to be effective in treating acne, but it is important for users to understand that significant reduction of skin blemishes may take time. It is common for treatment to last for 6 weeks or more before noticeable improvements become visible.


Although there are no reported negative drug interactions associated with Duac topical gel and other prescription medications, it is important to inform your doctor about all the medications you are currently taking before obtaining a prescription.

Side Effects

Some of the common side effects of Duac Gel may include dry skin, redness, burning, itching, stinging, a tingly sensation, redness or irritation, and skin peeling.

Frequently asked questions about Duac

Do you leave Duac on overnight?

Yes, Duac topical gel is typically applied to the affected area once daily, preferably in the evening or as directed by a healthcare provider. After washing and drying the skin, a thin layer of the gel is applied. It's important to avoid the eyes, lips, and inside of the nose when applying.

Can you buy Duac over the counter?

As of now, Duac acne gel is not available over the counter. It requires a prescription from a healthcare provider. However, you can conveniently obtain this medication online from CanPharm, which offers a wide range of prescription medications.

Does Duac need to be refrigerated?

Yes, Duac topical gel should be stored in a refrigerator between 2°C and 8°C before it's dispensed. However, after you receive it, Duac can be stored at room temperature up to 25°C for up to 60 days. Avoid freezing the gel as it can affect its efficacy.

How long does Duac take to work?

When using Duac acne gel, most people start to see an improvement in their acne within 2 to 5 weeks of treatment. However, the full effects of the gel may not be seen until up to 11 weeks of consistent use. Remember, acne treatment takes time and patience is key.

What happens when you stop using Duac?

If you stop using Duac topical gel abruptly, your acne may return. It's important to use the gel as directed by your healthcare provider, even if your symptoms improve. If you wish to stop the treatment, it's recommended to gradually reduce the frequency of application rather than stopping all at once.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.