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Estraderm Patch (Estradiol)

Also Known as Estraderm MX / TTS

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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The Estradiol patch is a form of estrogen replacement therapy used to manage menopausal symptoms like abnormal uterine bleeding, hot flashes, sweating, and chills. It contains estradiol, a female hormone produced by the ovaries. Menopause, typically occurring around age 50, leads to decreased estrogen production and related symptoms. Women who haven't had a hysterectomy need to take progestin alongside the patch to prevent complications. Some forms of the patch also help prevent osteoporosis by addressing low estrogen levels and slowing down bone loss. It should be used in conjunction with other measures like calcium and vitamin D supplements, quitting smoking, and regular exercise.

Before you buy Estraderm patch, it is important to consult with your healthcare provider and obtain a prescription for it and understand its effectiveness and potential side effects.

Fact Table
Formula C18H24O2
License FDA-Approved
Bioavailability Less than 5%
Legal status Prescription drug
Chemical Name Estradiol
Elimination half-life 13–20 hours
Dosage (Strength) 0.025mg, 0.05mg, 0.1mg
Pregnancy Consult a doctor
Brands Estraderm Patch
Protein binding 98%
PubChem CID 5757
MedlinePlus a605041
ChEBI 16469
ATC code G03CA03
DrugBank DB00783
KEGG D00105
Routes of administration Patch

Buy Estraderm Patch (Estradiol) online from online Canadian Pharmacy |


The specific estraderm dosage will be determined by your healthcare provider based on your condition and hormone levels but generally, it is applied the same days twice a week, with a change every 3 to 4 days.

Apply the patch to the buttocks, lower back, lower abdomen, or hip. Avoid applying it to the breasts or the same site consecutively.

Choose clean, dry, intact skin. Open the pouch, remove the protective layer, and immediately apply the patch, avoiding touching the adhesive. Hold it in place for 10 seconds, ensuring it sticks well.

When changing the patch, carefully remove the old one, fold it with adhesive sides together, and dispose of it properly. Gently rub off any remaining adhesive on the skin.

Bathing, showering, swimming, or contact with water does not affect the patch. However, hot water or steam may loosen it. Reapply or use a new patch if it falls off.

If you forget to apply or change the patch, do it as soon as you remember. If close to the regular change day, still apply it and resume the usual schedule. Do not wear two patches simultaneously.


The active ingredient in Estraderm Patch is Estradiol.


Make sure you give your complete medical history and information on allergies if any to your healthcare provider.

Ensure that the area where you will apply the patch is clean, dry, and free from any lotions, oils, or powders. This helps with proper adhesion and absorption of the medication.

Follow the instructions provided with the patch for correct placement on the body. To avoid skin irritation, it is recommended to alternate the application site with each new patch.

Do not cut or alter the patch in any way, as it may affect the release of the medication. Avoid exposing the patch to excessive heat, such as hot baths, saunas, or heating pads.

Keep track of the patch application schedule and replace it as directed by your healthcare provider.


There may be interaction between this medication and anastrozole, apixaban, aprepitant, ascorbic acid, itraconazole, ketoconazole, voriconazole, pentobarbital, phenobarbital, bosentan, carbamazepine, celecoxib, crizotinib, dabrafenib, lapatinib, nilotinib, sunitinib, clozapine, cobicistat, conivaptan, dexamethasone, prednisolone, prednisone, cyclosporine, dabigatran, dantrolene, canagliflozin, chlorpropamide, glyburide, insulin, linagliptin, metformin, rosiglitazone, deferasirox, dehydroepiandrosterone, diltiazem, dronedarone, eslicarbazepine, exemestane, heparin, efavirenz, etravirine, nevirapine, atazanavir, indinavir, ritonavir, saquinavir, Hyaluronidase, lamotrigine, lenalidomide, dalteparin, enoxaparin, tinzaparin, lumacaftor and ivacaftor, clarithromycin, erythromycin, atenolol, ramipril, enalapril, lisinopril, amlodipine, mifepristone, mitotane, modafinil, oxcarbazepine, phenytoin, primidone, rifabutin, rifampin, rivaroxaban, ropinirole, St. John's wort, sarilumab, saw palmetto, siltuximab, somatropin, soybean, thalidomide, aminophylline, oxtriphylline, theophylline, levothyroxine), tizanidine, tocilizumab, topiramate, ursodiol, verapamil, warfarin.

Side Effects

Possible Estraderm side effects include skin irritation, breast tenderness or enlargement, headaches, nausea, mood changes, vaginal bleeding or spotting, fluid retention, and an increased risk of blood clots. If you experience any severe side effects, it is crucial to promptly get in touch with your doctor.

Frequently Asked Questions about Estradiol Patch

What does the Estradiol patch do for you?

Estradiol is a form of estrogen, and it is commonly used to alleviate symptoms associated with menopause, such as hot flashes, vaginal dryness, and mood swings. The patch delivers the hormone estradiol into the body through the skin and can also help prevent bone loss (osteoporosis) and may be prescribed in hormone replacement therapy (HRT) to address hormonal imbalances or deficiencies.

What are the problems with Estradiol patches?

Estradiol patches can have potential problems or side effects, including skin irritation, allergic reactions, discomfort, hormonal side effects, and an increased risk of blood clots. Make sure you discuss these concerns with your healthcare provider.

Do Estradiol patches cause weight gain?

There is a common belief among women that hormone replacement therapy (HRT) leads to weight gain, but there is no scientific evidence to support this notion. Weight gain during menopause can occur irrespective of HRT use. Engaging in regular exercise and maintaining a healthy diet can help in losing any undesired weight.

What should I avoid while taking Estradiol?

Avoid smoking, grapefruit and grapefruit juice, excessive alcohol, and certain medications while taking Estradiol. It's important to inform your doctor about all the medications and hormonal therapies you are taking.

How long does it take for Estradiol patch to start working?

The exact timeframe for the Estradiol patch to start working can vary among individuals. However, generally, it may take a few days to a few weeks for the effects of the Estradiol patch to become noticeable. It is important to follow the prescribed dosage and application instructions provided by your healthcare provider.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.