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Estring (Estradiol)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Estring is a medication containing estradiol, an estrogen hormone used in hormone replacement therapy for menopausal symptoms. It is inserted into the vagina as a flexible ring, releasing a controlled dose of estradiol over approximately 90 days. It helps alleviate vaginal symptoms such as vaginal irritation, dryness, or pain during sex by restoring moisture and thickness to the vaginal lining.

Before you plan to buy Estring to reduce the vaginal and urinary symptoms of menopause, it is important to understand its effectiveness, potential side effects, and the Estring cost.

What is menopause?

Menopause is a natural process in women that occurs as they age, typically in their late 40s to early 50s. It marks the end of reproductive years and the cessation of menstrual periods. Hormonal changes during menopause can cause symptoms like hot flashes, mood swings, and vaginal dryness. Maintaining a healthy lifestyle and seeking medical guidance to manage symptoms and reduce health risks is essential.

Fact Table
Formula C18H24O2
License EU EMA
Bioavailability Less than 5%
Legal status Rx-Only
Chemical Name Estradiol
Elimination half-life 13 - 36.5 hours
Dosage (Strength) 2mg
Pregnancy Consult Doctor
Brands Estring
Protein binding 98%
PubChem CID 5757
MedlinePlus a605041
ChEBI 16469
ATC code G03CA03
DrugBank DB00783
KEGG D00105
Routes of administration By mouth (tablets)

Buy Estring (Estradiol) online from online Canadian Pharmacy |


Ensure you learn this medication's proper usage from your doctor or pharmacist.

  • Wash and dry your hands before handling the Estring ring.
  • Insert the ring high into the vagina.
  • The ring should be left in place for 90 days, then replaced if necessary. Stay within 90 days with the same ring.
  • The ring should not be felt or interfere with sexual intercourse if inserted correctly. If you feel the ring or experience discomfort, gently push it higher.
  • If the ring falls out, rinse it with lukewarm water and reinsert it. Contact your doctor if it falls out often.
  • Hatch your finger through the ring and gently pull it out to remove it.
  • Please dispose of the used ring in the trash; do not flush it down the toilet.

It may take 2 to 3 weeks to experience the full benefits of the medication.


The active ingredient in Estring is Estradiol.


Inform your doctor or allergic to estradiol or have any other allergies.

Discuss your medical history with your doctor or pharmacist, especially regarding vaginal bleeding of unknown cause, certain cancers, blood clots, stroke, heart disease, liver disease, kidney disease, family medical history of breast lumps/cancer/blood clots, angioedema, blood clotting disorders, high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, hypothyroidism, mineral imbalance, hypoparathyroidism, uterus problems, gallbladder disease, asthma, seizures, migraine headaches, mental/mood disorders, porphyria, and frequent vaginal infections.

Avoid smoking, combined with estrogen use, and smoking increases the risk of stroke, blood clots, high blood pressure, and heart attack.

This medication may cause dark areas on the face and skin. Limit sun exposure and use sunscreen.


This medication may interact with certain products, including anastrozole, exemestane, letrozole, fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, and tranexamic acid.

Side Effects

Estring may cause side effects like vaginal discomfort, headache, breast tenderness, abdominal pain, back pain, nausea and vomiting, fluid retention, mood changes, and skin reactions. If you experience any other symptoms, be sure to get in touch with your healthcare professional immediately.

Frequently Asked Questions about Estring

Why is Estring so expensive?

Estring is expensive due to its innovative delivery method for menopause medication and the unique nature of the product. Estring may not become available in a generic form. You can get the best price on Estring online in Canada and Canpharm.

How long is it safe to use Estring?

After using Estring continuously for 90 days, it is recommended to remove the ring. If ongoing treatment is necessary, a new flexible ring should be inserted. Estring is prescribed for short-term or long-term use, depending on the specific symptoms being treated and the individual's overall health.

When will Estring go generic?

Estring is not available in a generic form yet because of the unique nature of this product and its innovative delivery method.

Can Estring cause yeast infections?

Estring can alter the vaginal environment by providing localized estrogen therapy, which may disrupt the natural balance of bacteria and yeast in the vagina. This disruption can create an environment conducive to the overgrowth of yeast, leading to the development of a yeast infection.

Does Estring cause weight gain?

Weight gain is not a common side effect of Estring, but individual responses may vary. Consult your healthcare provider for personalized advice if you have concerns about weight changes while using Estring.

Can you use Estring with no cervix?

Yes, Estring can be used by individuals who have undergone a hysterectomy and do not have a cervix. Since Estring is a vaginal ring that delivers estrogen directly to the vaginal area, the presence or absence of a cervix does not affect its effectiveness. It can relieve localized symptoms such as vaginal dryness, itching, and discomfort.

Does Estring help with hot flashes?

Yes, Estring can help alleviate hot flashes in some women. Hot flashes are a common symptom of menopause. Estring, which delivers a controlled dose of estradiol directly to the vaginal area, can help reduce the frequency and intensity of hot flashes. The Estring helps regulate hormonal fluctuations contributing to hot flashes by replenishing estrogen levels.

How long Does Estring last?

The Estring is typically designed to be worn for three months (90 days) before it needs to be replaced with a new ring. It continuously releases a controlled amount of estradiol over this period.

How long Does it take for Estring to work?

Generally, it may take approximately 2 to 3 weeks of consistent use for the full benefits of Estring to be noticeable. During this time, the body gradually absorbs the estradiol released by the ring, and the hormonal levels stabilize.

How to get Estring out?

To remove the Estring, start by washing your hands. Find a comfortable position, insert a finger into your vagina, and locate the Estring. Hook your finger around the ring and gently pull it out. Dispose of the ring correctly.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.