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Glucotrol (Glipizide)

Also Known as Melizide

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Glucotrol (Glipizide) is a medication primarily used to manage type 2 diabetes. It belongs to the class of drugs called sulfonylureas, which work by stimulating the release of insulin from the pancreas and increasing the body's sensitivity to insulin. Glucotrol helps lower blood sugar levels by promoting the utilization of glucose by the body's cells. It is typically prescribed alongside a proper diet and exercise regimen for effective diabetes management.

When planning to buy Glucotrol, it is crucial to consider factors such as effectiveness, potential side effects, and cost.?

What is type 2 diabetes?

Type 2 diabetes is a chronic metabolic disorder characterized by two main factors: insulin resistance and relative insulin deficiency. It is the most common form of diabetes and is influenced by genetic and lifestyle factors. Treatment involves lifestyle modifications, medications, and regular monitoring to manage blood sugar levels and prevent complications.

Fact Table
Formula C21H27N5O4S
License US FDA, US DailyMed, EU EMA
Bioavailability 100%
Legal status Prescription drug
Chemical Name Glipizide
Elimination half-life 2 to 5 hours
Dosage (Strength) 5mg, 10mg
Pregnancy Consult a doctor
Brands Glucotrol
Protein binding 98 to 99%
PubChem CID 3478
MedlinePlus a684060
ChEBI 5384
ATC code A10BB07
DrugBank DB01067
KEGG D00335
Routes of administration By Mouth

Buy Glucotrol (Glipizide) online from online Canadian Pharmacy |


The Glucotrol dosage is determined based on your specific medical condition and how you respond to the treatment. Your doctor may advise taking it once daily or twice daily for higher doses.

Take this medication by mouth before breakfast or the first meal, as directed by your doctor.

Start with a low dose and follow your doctor's instructions for dose adjustments.

If you are already taking another diabetes drug, follow your doctor's directions for transitioning to glipizide.

Take the medication regularly at the same time each day to maximize its benefits.


Glipizide is the active ingredient in Glucotrol.


Inform your doctor of any allergies you have before taking glipizide.

Discuss your medical history, especially liver disease, kidney disease, thyroid disease, hormonal conditions, and electrolyte imbalance, with your doctor or pharmacist.

Be cautious of potential side effects such as blurred vision, dizziness, or drowsiness due to low or high blood sugar levels.

Limit alcohol intake as it can increase the risk of low blood sugar and potentially interact with glipizide.

Take precautions against sun sensitivity by limiting sun exposure, using sunscreen, and wearing protective clothing.

Discuss the use of glipizide during pregnancy or breastfeeding with your doctor.


This medication could have negative drug interactions with aspirin, metformin, sitagliptin, insulin glargine, furosemide, lisinopril, levothyroxine, metoprolol, among others. Before starting your treatment with Glucotrol, it is crucial to inform your doctor about all the medications you are currently taking.

Side Effects

Common Glucotrol side effects may include nausea, vomiting, reduced appetite, diarrhea, constipation, stomach discomfort, headache, and weight gain. If any of these side effects persist or worsen, it is important to inform your doctor promptly.

Frequently Asked Questions about Glucotrol (Glipizide)

Is metformin and Glucotrol the same?

Metformin and Glucotrol (glipizide) are both medications used to manage type 2 diabetes, but they belong to different drug classes and have distinct mechanisms of action. Metformin is a biguanide that reduces glucose production, while Glucotrol is a sulfonylurea that stimulates insulin release. Their usage depends on individual circumstances and should be determined by a healthcare professional.

What is glipizide used for?

Glipizide is a medication primarily used to manage type 2 diabetes. It belongs to a class of drugs called sulfonylureas, which work by stimulating the release of insulin from the pancreas and increasing the body's sensitivity to insulin. Glipizide helps lower blood sugar levels in individuals with type 2 diabetes by assisting the body in utilizing insulin effectively.

How does glipizide work?

Glipizide, as a sulfonylurea medication, works by stimulating the release of insulin from the beta cells in the pancreas. Insulin is a hormone essential for regulating blood sugar levels in the body. When blood sugar levels rise, glipizide helps the beta cells in the pancreas produce and release more insulin into the bloodstream.

Does glipizide lower blood sugar immediately?

Glipizide typically starts working relatively quickly after ingestion, but the onset and duration of its blood sugar-lowering effects can vary. The medication is usually taken orally, and its effects can be observed within 30 minutes to an hour after ingestion. However, it's important to note that glipizide is not meant to provide an immediate or rapid reduction in blood sugar levels like some other medications.

How long does glipizide stay in your system?

The elimination half-life of glipizide, which is the time it takes for half of the medication to be eliminated from the body, is approximately 2 to 4 hours. This means that it takes around 2 to 4 hours for half of the glipizide dose to be metabolized and excreted.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.