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Glucotrol XL (Glipizide ER)

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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Glucotrol XL is a Type 2 diabetes medication available by prescription and used to lower blood sugar levels. Glipizide is a sulfonylureas drugs that promotes more production of the body’s natural insulin. Glucotrol XL is the extended-release version of this medication, meaning the active ingredient is introduced to the bloodstream at a slower and more gradual rate, and for some Type 2 diabetics this slowed delivery is what's needed for their optimal blood sugar control. Buy Glucotrol XL from Canada and Canpharm and get the best Glucotrol XL price.

What is Type 2 Diabetes?

Type 2 diabetes is a condition where the body does not produce enough insulin required to take blood sugar and channel it into cells for energy. When a person is not diabetic, they will have the insulin levels required to ensure this happens to the extent it needs to, and blood sugar levels stay low as a result. Untreated Type 2 diabetes can lead to heart attack, stroke, kidney damage, vision loss, and sexual dysfunction.

Fact Table
Formula C21H27N5O4S
License US DailyMed
Bioavailability 100% (regular formulation) 90% (extended release)
Legal status Prescription Drugs
Chemical Name Glipizide ER
Elimination half-life 2 to 5 hours
Dosage (Strength) 2.5mg, 5mg, 10mg
Pregnancy Consult Doctor
Brands Glucotrol XL
Protein binding 98 to 99%
PubChem CID 3478
MedlinePlus a684060
ChEBI 5384
ATC code A10BB07
DrugBank DB01067
KEGG D00335
Routes of administration By mouth

Buy Glucotrol XL (Glipizide ER) online from online Canadian Pharmacy |


Standard Glucotrol XL dosage is to take one 2.5mg, 5mg, or 10mg tablet 1x daily. It is common for physicians to recommend starting at a lower dose and moving up to a higher one to minimize Glucotrol side effects.


The active ingredient in Glucotrol is Glipizide ER (extended release)


Let your doctor know of any history of liver or kidney disease, thyroid disorder, hormonal conditions like adrenal / pituitary insufficiency and antidiuretic hormone-SIADH, hyponatremia (electrolyte imbalance) or stomach / intestinal problems like gastrointestinal stenosis or gastroparesis before starting on Glucotrol XL.

Medication may cause blurred vision, drowsiness, or dizziness

Users should limit alcohol consumption while using this medication because it can increase the risk of low blood sugar. Excessive consumption while on Glucotrol XL may cause facial flushing, vomiting, nausea, vomiting, dizziness, or stomach pain.

Excess stress may cause this medication to work less effectively


Negative drug interactions may occur between Glucotrol XL and other Rx medications, including amlodipine, atorvastatin, losartan, rosuvastatin, metformin, hydrochlorothiazide, sitagliptin, insulin glargine, furosemide, lisinopril, metoprolol, gabapentin, esomeprazole, amlodipine, omeprazole, clopidogrel, simvastatin, montelukast, levothyroxine.

Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Glucotrol XL online.

Side Effects

Glucotrol XL side effects may occur, and some users may experience nausea, appetite loss, nauseas, constipation, diarrhea, stomach upset, gas, headache, or weight gain. If side effects are experienced, you may want to stop use and meet with a doctor again to discuss Type 2 diabetes treatment medication alternatives.

Frequently Asked Questions about Glucotrol XL

Is there any difference between Glucotrol and Glucophage?

These medications are very similar in their constituency and their efficacy methods. Doctors will often prescribe Glucotrol and Glucophage together. One important note is that Glucotrol is more likely to cause hypoglycemia (low blood sugar) than Glucophage, so individuals who are prone to have low blood sugar despite being Type 2 diabetic may be better off using Glucophage. This determination is only to be made by a doctor.

Will older people need a lower dosage of Glucotrol XL?

This is quite common, as people over the age of 65 will have a higher risk of hypoglycemia and so doctors will usually prescribe the 2.5mg Glucophage tablet to start.

Does Glucotrol XL cause weight gain?

It is possible for Glucotrol XL to cause people to gain weight. The explanation for this is that sulfonylurea medications make it so that some of the blood sugar redirected into cells is stored as fat. This can lead to weight gain over time.

Can children with diabetes use Glucotrol XL?

No, this medication is not FDA-approved for anyone under the age of 16. A doctor will be able to advise on the best diabetes management approach for diabetics under this age, and other blood sugar control medications will be a better fit.