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Heartgard Plus (Ivermectin / Pyrantel)

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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Heartgard Plus is a chewable tablet medication that provides complete protection against heartworms in dogs, while also preventing roundworms and hookworms. It is a safe and effective medication that can be given to dogs as young as 6 weeks old. Heartgard Plus can be used without any safety concerns in pregnant or nursing female dogs, stud dogs, dogs with collie genetics, and collies.

Heartgard Plus chewables are a convenient and effective way to protect your dog from heartworm disease, and with proper use, can help keep your furry friend healthy and happy.

Fact Table
Formula Ivermectin: C48H74O14, Pyrantel: C11H14N2S
License FDA-approved for veterinary use
Bioavailability Ivermectin: Well absorbed orally, Pyrantel: Poorly absorbed
Legal status Veterinary prescription drug
Chemical Name Ivermectin / pyrimidine
Elimination half-life Ivermectin: Approx. 18 hrs in dogs, Pyrantel: Not well documented
Dosage (Strength) it varies
Pregnancy Consult veterinarian for pregnant animals
Brands Heartgard Plus
Protein binding Ivermectin: Approx. 93%, Pyrantel: Not available
PubChem CID Ivermectin: 6321424, Pyrantel: 708857
MedlinePlus Not applicable (veterinary medicine)
ChEBI Ivermectin: 6078, Pyrantel: 8684
ATC code Ivermectin: QP54AA01, Pyrantel: QP52AG02
DrugBank Ivermectin: DB00602, Pyrantel: DB11154
KEGG Ivermectin: D00804, Pyrantel: D08331
Routes of administration Oral (chewable tablets)

Buy Heartgard Plus (Ivermectin / Pyrantel) online from online Canadian Pharmacy |


Heartgard Plus should be?administered once a month?and based on the following guideline:?

  • dogs up to 25 pounds: 68 mcg / 57 mg
  • dogs 26-50 pounds: 136 mcg /114 mg
  • dogs 51-100 pounds: 272 mcg / 227 mg
  • dogs over 100 pounds will be given a combination of tablets using the above dosage guideline?

Take out one chewable at a time from the blister card with a foil backing.

To safeguard the product from light, place the blister card containing the remaining chewable back into its box.

It is important to ensure that the dog consumes the entire dose of the medication.


Heartgard Plus contains two active ingredients: Ivermectin and Pyrantel.


Heartgard Plus for dogs is generally safe, but there are some precautions that should be taken:

This product is for use only with dogs that are 6 weeks of age or older.

Before initiating treatment with Heartgard Plus, it is recommended that all dogs undergo testing to determine if they have a pre-existing heartworm infection.

Infected dogs must be treated to remove adult heartworms and microfilariae before starting a preventive program with Heartgard Plus.

The chewable tablets can be offered to your dog by hand or added to a small amount of dog food.

If your dog has difficulty swallowing the chewable whole, it can be broken into pieces and fed that way.


Heartgard Plus has no known medication interactions. However, any medications your dog is taking, including over-the-counter pharmaceuticals, supplements, and herbal therapies, should be disclosed to your veterinarian.

Side Effects

Although Heartgard Plus side effects are extremely uncommon, some dogs may encounter them. Among them are diarrhea, nausea, fatigue, anorexia, ataxia, convulsions, and a lack of effectiveness. It's crucial to remember that most of these incidents were minor and brief. Contact your veterinarian right away for advice if your dog exhibits any of these negative symptoms.

If you're looking to buy Heartgard Plus for your dog, it's important to talk to your veterinarian first. Your veterinarian can advise you on the ideal dosage for your dog and guarantee that the drug is safe for them to take.

Frequently Asked Questions about Heartgard Plus

Does Heartgard Plus kill fleas?

No, Heartgard Plus is primarily used for the prevention of heartworm disease in dogs. Heartgard Plus does not have flea-killing properties.

Does Heartgard Plus kill tapeworms?

No, Heartgard Plus is not effective against tapeworms. To treat or prevent tapeworm infestations, you will need a different medication specifically designed for tapeworms, such as praziquantel.

How often to give Heartgard Plus?

Heartgard Plus is typically given once a month to dogs as a preventive measure against heartworm disease.

Can a dog overdose on Heartgard Plus?

When used according to the recommended dosage, Heartgard Plus is generally safe for dogs and has a wide margin of safety. However, in rare cases of overdose or sensitivity, dogs may experience symptoms such as vomiting, diarrhea, or lethargy.

Can Heartgard Plus cause diarrhea?

In some cases, Heartgard Plus may cause gastrointestinal side effects in dogs, including diarrhea.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.