Jevtana (Cabazitaxel)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | Not applicable (chemotherapy drug) |
| License | FDA approved |
| Bioavailability | Not applicable (intravenous infusion) |
| Legal status | Prescription required |
| Chemical Name | Cabazitaxel |
| Elimination half-life | Approximately 95 hours |
| Dosage (Strength) | Varies depending on the patient's condition and response to treatment |
| Pregnancy | Category D - Positive evidence of risk; consult healthcare provider regarding potential benefits and risks |
| Brands | Jevtana |
| Protein binding | Approximately 89-92% |
| PubChem CID | 6918838 (for Cabazitaxel) |
| MedlinePlus | a611058 (for Cabazitaxel) |
| ChEBI | 68862 (for Cabazitaxel) |
| ATC code | L01CD13 |
| DrugBank | DB04844 (Cabazitaxel) |
| KEGG | D09365 (Cabazitaxel) |
| Routes of administration | Intravenous infusion |
Jevtana (cabazitaxel) is an injectable anticancer medication primarily used for the treatment of prostate cancer. Jevtana belongs to a class of drugs known as taxanes, which work by disrupting the normal function of microtubules, essential components in cell division. This disruption inhibits cancer cell growth and proliferation, particularly targeting cells in the rapidly dividing phase. Jevtana is typically prescribed for patients with metastatic hormone-refractory prostate cancer, especially those who have previously received a docetaxel-based chemotherapy regimen.
Before you buy Jevtana, it is crucial that you talk to your healthcare provider about potential side effects and Jevtana cost.
Directions
Directions:
Jevtana is administered as an intravenous (IV) infusion. Treatment should only be carried out under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
Dosage:
The standard dosage of Jevtana is based on the patient's body surface area, usually 25 mg/m2;.
Jevtana is administered once every three weeks.
Pre-medication with a corticosteroid, such as oral prednisone, is recommended to reduce the risk of certain side effects like fluid retention and hypersensitivity reactions.
Administration:
The infusion lasts approximately one hour.
Patients should be premedicated with anti-allergy medications (antihistamines) and corticosteroids to prevent hypersensitivity reactions.
Continuous monitoring during infusion for any adverse reaction is critical.
Ingredients
Active Ingredient: Cabazitaxel.
Cautions
Jevtana must be used with caution in patients with:
Liver impairment: Dose adjustments may be necessary.
Neutropenia: Patients should be monitored for signs of infection.
Kidney disease: Jevtana can affect renal function.
History of severe hypersensitivity reactions to cabazitaxel or other components in the formulation.
Interactions
Jevtana can interact with several other medications, potentially affecting its effectiveness or increasing side effects. Important interactions include:
Strong CYP3A inhibitors (e.g., ketoconazole, itraconazole): Can increase plasma concentration of cabazitaxel.
Strong CYP3A inducers (e.g., rifampicin, phenytoin): May decrease the effectiveness of cabazitaxel.
Anticoagulants (e.g., warfarin): Increased risk of bleeding.
Patients should always inform their healthcare providers about all medications they are taking, including over-the-counter drugs and herbal supplements.
Side Effects
Common side effects of Jevtana for prostate cancer include, but are not limited to:
- Neutropenia
- Anemia
- Thrombocytopenia
- Nausea and vomiting
- Diarrhea
- Fatigue
- Alopecia (hair loss)
- Peripheral neuropathy (numbness or tingling in hands and feet)
Frequently Asked Questions about Jevtana
What is Jevtana used for?
Jevtana is used to treat metastatic hormone-refractory prostate cancer, particularly in patients who have previously received a chemotherapy regimen that included docetaxel.
How is Jevtana administered?
Jevtana is administered through an intravenous (IV) infusion over approximately one hour, every three weeks, under the supervision of a healthcare provider.
Are there any dietary restrictions while receiving Jevtana?
There are no specific dietary restrictions while receiving Jevtana, but patients are advised to discuss their diet with their healthcare provider.
What are common side effects of Jevtana?
Common side effects include neutropenia, anemia, nausea, diarrhea, fatigue, hair loss, and peripheral neuropathy.
Can Jevtana cure prostate cancer?
Jevtana is not a cure for prostate cancer but is used to help control its spread and manage symptoms.
Is Jevtana safe for all cancer patients?
Jevtana is specifically indicated for prostate cancer and may not be suitable for other types of cancer. Its safety and efficacy depend on individual health conditions and previous treatments.
How should I prepare for my Jevtana treatment?
Patients are typically premedicated with corticosteroids and antihistamines to reduce the risk of hypersensitivity reactions. It's important to discuss all preparations with your healthcare provider.
What should I do if I miss a dose of Jevtana?
It is crucial to maintain a regular treatment schedule, but if a dose is missed, contact your healthcare provider immediately to reschedule.
Can I take other medications while receiving Jevtana?
Some medications can interact with Jevtana, affecting its effectiveness or increasing side effects. Always inform your healthcare provider about all other medications you are taking.
Where is Jevtana treatment available?
Jevtana treatment is available at specialized cancer treatment centers and hospitals where chemotherapy infusions are administered by healthcare professionals experienced in cancer treatments.
