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Matulane (Procarbazine)

Prescription requiredOnly Available By Prescription
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Top Generic choice

What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Matulane is a Hodgkins lymphoma treatment medication available by prescription and it is often prescribed along with other medications as part of an advanced-stage cancer treatment regimen. Procarbazine is an alkylating drug, and it works by making cancer cells unable to make the proteins and genetic material needed for the cells to grow and survive. Matulane is usually prescribed for patients with Stage 3 or Stage 4 Hodgkin's lymphoma. Buy Matulane from Canada and Canpharm and get the lowest Matulane cost on it.

What is Hodgkin's Lymphoma?

Hodgkin's lymphoma is a type of blood cancer that affects the lymphatic system. Lymphocytes (white blood cells) increase in numbers exponentially and mutate into abnormal and cancerous Reed-Sternberg cells causing swollen lymph nodes. There are four Hodgkin's lymphoma subtypes, with nodular sclerosing Hodgkin lymphoma, mixed cellularity Hodgkin lymphoma, lymphocyte-rich Hodgkin lymphoma, and lymphocyte depleted Hodgkin lymphoma. This cancer tends to occur most frequently in people between the ages of 20 to 40 or then after 65.

Fact Table
Formula C12H19N3O
License FDA-approved
Bioavailability Well absorbed from the gastrointestinal tract
Legal status Prescription only (Rx)
Chemical Name Procarbazine
Elimination half-life Approximately 10 minutes (parent compound), metabolites vary
Dosage (Strength) Capsules: 50 mg
Pregnancy advice Contraindicated; Category D by FDA
Brands Matulane
Protein binding Low (<10%)
PubChem CID 4915
MedlinePlus a682094
ChEBI 8064
ATC code L01XX04
DrugBank DB01168
KEGG D08421
Routes of administration Oral

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The standard dosage is to take Matulane 50mg 1 or 2x daily for an initial 2-week treatment period. Use will then be stopped for a time and repeated. This will be explained in detail in your prescription, and you should always take your medication exactly as indicated in it.

Do not chew or crush tablets. Always take whole with water.


The active ingredient in Matulane is Procarbazine.


Let your doctor know of any history of kidney or liver disease, bleeding problems, recurrent infections, high blood pressure, or are undergoing radiation treatment before starting on Matulane

High blood pressure risk may require following a very specific diet while using Matulane, and you should avoid food and beverages that are high in tyramine

Use of this medication may make you drowsy or dizzy

Limit alcohol consumption while using Matulane

Smoking cigarettes or other tobacco products may increase your risk of lung cancer while using Matulane


Negative drug interactions may occur between Matulane and other Rx medications, including diethylpropion, atomoxetine, methylphenidate, apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, dextromethorphan, methyldopa, metoclopramide, tetrabenazine, valbenazine, meperidine, methadone, tapentadol, rizatriptan, sumatriptan, entacapone, levodopa, tolcapone, maprotiline, mirtazapine, fluoxetine, paroxetine, duloxetine, venlafaxine, amitriptyline, and doxepin.

Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Matulane online.

Side Effects

Matulane side effects may occur, and some users may experience nausea, vomiting, appetite loss, constipation, sleeping difficulties, muscle or joint pain, or darkening of the skin. If side effects are experienced, you may want to stop use and meet with a doctor again to discuss Hodgkin lymphoma treatment medication alternatives.

Remember, these are not exhaustive lists, and it's important to consult with a healthcare professional for personalized advice and guidance. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit or call 1-800-FDA-1088

Frequently Asked Questions about Matulane (Procarbazine)

What is the brand name for Matulane?

The brand name for this medication is Procarbazine.

Who is the manufacturer of Matulane?

The manufacturer of this medication is Leadiant Biosciences, Inc.

What foods to avoid when taking Procarbazine?

You should avoid eating foods that are high in Tyramine while you are using Matulane. These include avocados, bananas, figs, papaya, raisins, sauerkraut, aged or fermented meats, wine and tap beer, aged cheeses, soy sauce, miso soup, fava beans, bean curd, yogurts, and any foods containing yeast extracts.

What type of medicine is Procarbazine?

Procarbazine is an alkylating medication used to slow and disable cancerous cell growth.

What is the mechanism of Procarbazine?

Procarbazine promotes the breakdown of DNA in cells so that they cannot grow or duplicate to expand and grow the cancer.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.