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Nivestym (Filgrastim)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Nivestym (Filgrastim), a biosimilar to the original recombinant human granulocyte colony-stimulating factor (G-CSF), is designed to help patients with neutropenia, a condition characterized by unusually low levels of neutrophils, a type of white blood cell vital for fighting off infections. This medication is specifically engineered to stimulate the bone marrow to produce more neutrophils, thus enhancing the body's ability to combat infections, especially in patients undergoing chemotherapy, those with acute myeloid leukemia, and individuals undergoing bone marrow transplants.

Nivestym is produced through recombinant DNA technology in E. coli expression systems and is structurally identical to the naturally occurring protein in humans that stimulates the growth of white blood cells. Each prefilled syringe of Nivestym contains a sterile, clear, colorless, preservative-free solution intended for subcutaneous injection. Before you buy Nivestym, it is crucial that you talk to your healthcare provider about potential side effects and Nivestym cost.

Fact Table
Formula C845H1343N223O243S9
License FDA approved
Bioavailability 62% (subcutaneous)
Legal status Prescription Drugs
Chemical Name Filgrastim
Elimination half-life 3.5 hours
Dosage (Strength) 300 µg/mL or 480 µg/mL (injection)
Pregnancy Use with caution; consult healthcare provider
Brands Nivestym
Protein binding Not significantly protein-bound
PubChem CID 123819
MedlinePlus a692001
ChEBI 500596
ATC code L03AA02
DrugBank DB00036 (Filgrastim)
KEGG D00746 (Filgrastim)
Routes of administration Subcutaneous, intravenous

Buy Nivestym (Filgrastim) online from online Canadian Pharmacy |


Nivestym injection should be administered according to specific medical advice, tailored to the individual needs of each patient. It is typically injected subcutaneously, though it can also be given intravenously under certain medical circumstances. The dosage and duration of the treatment depend on the patient's medical condition, body weight, and response to therapy.


The active ingredient in Nivestym is filgrastim.


There have been reports of sickle cell crises following the administration of filgrastim products.

Use with caution in cases of chronic myeloid leukemia and myelodysplastic syndromes due to the risk of worsening these conditions.

Patients with a known allergy to filgrastim or any component of the product should avoid using this medication.

Additionally, special attention should be given to patients with pre-existing lung conditions as severe respiratory side effects can occur.


Filgrastim may interact with other drugs, although specific drug-drug interactions are not well documented. However, it is important to inform the healthcare provider of all medications currently being taken, including over-the-counter drugs, vitamins, and herbal supplements to avoid any potential interaction. Particularly, drugs affecting blood cells and immune response may alter the effectiveness or side effect profile of Nivestym.

Side Effects

While Nivestym is effective in treating neutropenia, it may cause side effects in some individuals. The most common side effects include:

  • Bone pain
  • Injection site reactions
  • Headache and muscle aches.
  • Nausea and vomiting.

Frequently Asked Questions about Nivestym

What is Nivestym?

Nivestym is a biosimilar to Neupogen (filgrastim), which is a medication that stimulates the production of white blood cells (neutrophils) in the bone marrow. It is manufactured by Pfizer.

What is Nivestym used for?

Nivestym is used to prevent infections in patients who have certain types of cancer and are receiving chemotherapy that decreases the number of neutrophils. It is also used in patients undergoing bone marrow transplants, patients with severe chronic neutropenia, and for those undergoing peripheral blood progenitor cell collection and therapy.

What are the side effects of Nivestym?

Common side effects of Nivestym include:

  • Bone pain
  • Muscle aches
  • Headache
  • Injection site reactions (redness, swelling, pain)
  • Fever
  • Fatigue

Less common but more serious side effects include:

  • Spleen rupture
  • Acute respiratory distress syndrome (ARDS)
  • Allergic reactions
  • Capillary leak syndrome

How long do Nivestym side effects last?

The duration of side effects can vary depending on the individual and the specific side effect. Common side effects like bone pain and muscle aches often resolve shortly after the treatment course is completed. More severe side effects should be discussed with a healthcare provider as they can vary significantly.

How long does Nivestym stay in your system?

Nivestym typically stays in the system for about 3 to 4 days after administration. However, the effects on white blood cell production can last longer, depending on the patient's condition and response to the medication.

How to inject Nivestym

Nivestym is usually administered as a subcutaneous injection (under the skin) or sometimes as an intravenous infusion (into a vein). If self-administering at home, patients should follow their healthcare provider’s instructions carefully:

  1. Wash your hands thoroughly.
  2. Gather all necessary supplies (Nivestym pre-filled syringe, alcohol swabs, sterile gauze, etc.).
  3. Clean the injection site with an alcohol swab.
  4. Remove the cap from the needle.
  5. Pinch the skin and insert the needle at a 45-degree angle for subcutaneous injection.
  6. Push the plunger slowly to inject the medication.
  7. Remove the needle and apply gentle pressure with sterile gauze.
  8. Dispose of the syringe in a sharps container.

When is the best time to take Nivestym?

The timing of Nivestym administration depends on the specific treatment regimen and the type of chemotherapy being used. It is typically given at least 24 hours after a chemotherapy session. Patients should follow their healthcare provider's instructions regarding the exact timing.

Is Nivestym safe?

Nivestym is considered safe when used as directed under the supervision of a healthcare provider. However, like all medications, it can have side effects and potential risks, which should be discussed with a healthcare provider.

How fast does Nivestym work?

Nivestym begins to stimulate the production of white blood cells shortly after administration. The increase in neutrophil counts is usually observed within a few days, helping to reduce the risk of infection during periods of neutropenia.

Does Nivestym cause fatigue?

Fatigue can be a side effect of Nivestym, though it is not one of the most common side effects. If fatigue occurs, it should be discussed with a healthcare provider, as it could also be related to the underlying condition or other treatments.