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Orencia (Abatacept)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Orencia (Abatacept) is an immunosuppressive drug that targets the immune system to reduce inflammation and alter the progression of autoimmune diseases. It works by inhibiting T-cell activation, which plays a key role in the immune response involved in autoimmune diseases. Orencia is used primarily to treat moderate to severe rheumatoid arthritis, juvenile idiopathic arthritis in patients aged six years and older, and active psoriatic arthritis.

Before you buy Orencia injection, it is crucial that you talk to your healthcare provider about potential side effects and Orencia cost.

Fact Table
Formula Not applicable (biologic)
License FDA approved
Bioavailability Not applicable (biologic)
Legal status Prescription Drugs
Chemical Name Abatacept
Elimination half-life 13 days (subcutaneous), 14 days (intravenous)
Dosage (Strength) Varies depending on indication and patient weight
Pregnancy Category C - Risk cannot be ruled out; human studies inadequate or lacking
Brands Orencia
Protein binding Approx. 75% (intravenous), 73–80% (subcutaneous)
PubChem CID 10265982 (for abatacept)
MedlinePlus a605018 (for abatacept)
ChEBI 43053 (Abatacept)
ATC code L04AA24
DrugBank DB01281 (Abatacept)
KEGG D03252 (Abatacept)
Routes of administration Intravenous infusion or subcutaneous injection

Buy Orencia (Abatacept) online from online Canadian Pharmacy |


Orencia can be administered in two forms: as an intravenous infusion or as a subcutaneous injection.

Intravenous Infusion:

Orencia medication is administered by a healthcare professional once every 4 weeks after an initial loading phase.

The loading phase consists of additional doses at two weeks and four weeks after the first infusion.

Subcutaneous Injection:

After an initial intravenous dose, Orencia may be given as a weekly subcutaneous injection that can be administered at home.

Patients or caregivers are trained to properly inject Orencia.

Always adhere to the precise instructions given by your healthcare provider. Never change the dosage or frequency without their guidance.


The active ingredient in Orencia is abatacept.


Orencia should be used with caution in patients with a history of chronic infections or those susceptible to infections.

It is not recommended for use in patients with severe, progressive, or uncontrolled renal, hepatic, or hematological disease.

Avoid live vaccines before, during, and after treatment with Orencia as the response to vaccination may be diminished and the risk of infection can increase.

Use in pregnancy only if clearly needed and after a thorough assessment of the risks and benefits by a healthcare provider.


Orencia may interact with other immunosuppressive agents such as TNF blockers (e.g., etanercept, infliximab), other biologic drugs used for the treatment of similar conditions, certain vaccines, particularly live vaccines. Always inform your healthcare provider about all medications and supplements you are taking before starting Orencia.

Side Effects

Common side effects of Orencia include:

  • Headache
  • Upper respiratory tract infections
  • Nausea
  • Injection site reactions

Frequently Asked Questions about Orencia

What conditions does Orencia treat?

Orencia is used to treat rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis.

How is Orencia administered?

Orencia can be given as an intravenous infusion in a clinical setting or as a subcutaneous injection at home.

Can I take Orencia with other medications for arthritis?

Discuss all your current medications with your healthcare provider, as Orencia can interact with other drugs, especially other immunosuppressants.

What should I do if I miss a dose of Orencia?

If you miss a dose, administer it as soon as possible and then return to your regular schedule. If it's almost time for your next dose, skip the missed dose. Do not double up.

Can Orencia be used during pregnancy?

Orencia should only be used in pregnancy if necessary. Discuss the potential risks and benefits with your healthcare provider.

Are there any foods I should avoid while taking Orencia?

There are no specific foods that you need to avoid while taking Orencia, but maintaining a balanced diet is essential.

How long does it take for Orencia to work?

Some patients may notice improvement within a few weeks, but it can take several months for the full benefits to be realized.

What are the serious side effects of Orencia?

Serious side effects include serious infections, increased risk of cancer, and severe allergic reactions.

Can children use Orencia?

Yes, Orencia is approved for children aged six years and older with juvenile idiopathic arthritis.

What should I do if I experience side effects?

Contact your healthcare provider if you experience any side effects, especially if they are severe or do not go away.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.