Orencia (Abatacept)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | Not applicable (biologic) |
| License | FDA approved |
| Bioavailability | Not applicable (biologic) |
| Legal status | Prescription Drugs |
| Chemical Name | Abatacept |
| Elimination half-life | 13 days (subcutaneous), 14 days (intravenous) |
| Dosage (Strength) | Varies depending on indication and patient weight |
| Pregnancy | Category C - Risk cannot be ruled out; human studies inadequate or lacking |
| Brands | Orencia |
| Protein binding | Approx. 75% (intravenous), 73–80% (subcutaneous) |
| PubChem CID | 10265982 (for abatacept) |
| MedlinePlus | a605018 (for abatacept) |
| ChEBI | 43053 (Abatacept) |
| ATC code | L04AA24 |
| DrugBank | DB01281 (Abatacept) |
| KEGG | D03252 (Abatacept) |
| Routes of administration | Intravenous infusion or subcutaneous injection |
Orencia (Abatacept) is an immunosuppressive drug that targets the immune system to reduce inflammation and alter the progression of autoimmune diseases. It works by inhibiting T-cell activation, which plays a key role in the immune response involved in autoimmune diseases. Orencia is used primarily to treat moderate to severe rheumatoid arthritis, juvenile idiopathic arthritis in patients aged six years and older, and active psoriatic arthritis.
Before you buy Orencia injection, it is crucial that you talk to your healthcare provider about potential side effects and Orencia cost.
Directions
Orencia can be administered in two forms: as an intravenous infusion or as a subcutaneous injection.
Intravenous Infusion:
Orencia medication is administered by a healthcare professional once every 4 weeks after an initial loading phase.
The loading phase consists of additional doses at two weeks and four weeks after the first infusion.
Subcutaneous Injection:
After an initial intravenous dose, Orencia may be given as a weekly subcutaneous injection that can be administered at home.
Patients or caregivers are trained to properly inject Orencia.
Always adhere to the precise instructions given by your healthcare provider. Never change the dosage or frequency without their guidance.
Ingredients
The active ingredient in Orencia is abatacept.
Cautions
Orencia should be used with caution in patients with a history of chronic infections or those susceptible to infections.
It is not recommended for use in patients with severe, progressive, or uncontrolled renal, hepatic, or hematological disease.
Avoid live vaccines before, during, and after treatment with Orencia as the response to vaccination may be diminished and the risk of infection can increase.
Use in pregnancy only if clearly needed and after a thorough assessment of the risks and benefits by a healthcare provider.
Interactions
Orencia may interact with other immunosuppressive agents such as TNF blockers (e.g., etanercept, infliximab), other biologic drugs used for the treatment of similar conditions, certain vaccines, particularly live vaccines. Always inform your healthcare provider about all medications and supplements you are taking before starting Orencia.
Side Effects
Common side effects of Orencia include:
- Headache
- Upper respiratory tract infections
- Nausea
- Injection site reactions
Frequently Asked Questions about Orencia
What conditions does Orencia treat?
Orencia is used to treat rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis.
How is Orencia administered?
Orencia can be given as an intravenous infusion in a clinical setting or as a subcutaneous injection at home.
Can I take Orencia with other medications for arthritis?
Discuss all your current medications with your healthcare provider, as Orencia can interact with other drugs, especially other immunosuppressants.
What should I do if I miss a dose of Orencia?
If you miss a dose, administer it as soon as possible and then return to your regular schedule. If it's almost time for your next dose, skip the missed dose. Do not double up.
Can Orencia be used during pregnancy?
Orencia should only be used in pregnancy if necessary. Discuss the potential risks and benefits with your healthcare provider.
Are there any foods I should avoid while taking Orencia?
There are no specific foods that you need to avoid while taking Orencia, but maintaining a balanced diet is essential.
How long does it take for Orencia to work?
Some patients may notice improvement within a few weeks, but it can take several months for the full benefits to be realized.
What are the serious side effects of Orencia?
Serious side effects include serious infections, increased risk of cancer, and severe allergic reactions.
Can children use Orencia?
Yes, Orencia is approved for children aged six years and older with juvenile idiopathic arthritis.
What should I do if I experience side effects?
Contact your healthcare provider if you experience any side effects, especially if they are severe or do not go away.
