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Fact Table
| Fact Table | |
|---|---|
| Formula | Combination of Perindopril and Amlodipine |
| License | Prescription required |
| Bioavailability | Not specified for the combination |
| Legal status | Prescription required |
| Chemical Name | Perindopril and Amlodipine |
| Elimination half-life | Perindopril: 0.8 to 1 hour, Amlodipine: 30 to 50 hours |
| Dosage (Strength) | Various strengths available, depending on the prescribed dose |
| Pregnancy | Category C for Perindopril, Category C for Amlodipine - Risk cannot be ruled out; consult healthcare provider |
| Brands | Prestalia |
| Protein binding | Perindopril: 20 to 30%, Amlodipine: Approximately 97.5% |
| PubChem CID | Perindopril: 107807 (for Perindopril), Amlodipine: 2162 (for Amlodipine) |
| MedlinePlus | a604001 (for Perindopril), a692044 (for Amlodipine) |
| ChEBI | Perindopril: 47780 (for Perindopril), Amlodipine: 2385 (for Amlodipine) |
| ATC code | Perindopril: C09AA04, Amlodipine: C08CA01 |
| DrugBank | Perindopril: DB00790, Amlodipine: DB00381 |
| KEGG | Perindopril: D03753, Amlodipine: D07450 |
| Routes of administration | Oral |
Prestalia is a prescription medication specifically formulated to help manage hypertension (high blood pressure). By combining the actions of two active ingredients, perindopril arginine and amlodipine besylate, Prestalia provides a dual approach to controlling blood pressure, which may reduce the risk of cardiovascular events such as heart attacks and strokes. Perindopril arginine is an ACE inhibitor that relaxes blood vessels, while amlodipine besylate is a calcium channel blocker that helps to reduce heart strain and improve blood flow. This medication is typically prescribed when other treatments have not been effective or when a combination treatment is considered appropriate based on a patient's clinical profile.
Before you buy Prestalia, it is crucial that you talk to your healthcare provider about potential side effects and Prestalia cost.
Directions
Take Prestalia dosage exactly as prescribed by your healthcare provider. The typical starting dose is one tablet orally once per day. The dose may be adjusted based on your response to the treatment and any side effects you experience. Prestalia can be taken with or without food. Do not take more or less than instructed by your doctor. It's important to continue taking this medication even if you feel well, as high blood pressure often has no symptoms.
Ingredients
Active Ingredients: Perindopril Arginine and Amlodipine Besylate.
Cautions
Before starting Prestalia, inform your doctor if you have a history of angioedema, severe kidney disease, liver disease, or if you are pregnant or plan to become pregnant. Use of Prestalia during pregnancy can harm the fetus, especially in the second and third trimesters.
Avoid potassium supplements or salt substitutes containing potassium without first checking with your doctor, as this medication can increase potassium levels in your blood.
Interactions
Prestalia may interact with other medications, which can increase your risk of severe side effects or affect how your medications work. It is important to discuss all medications you are currently taking with your doctor, including prescription and over-the-counter drugs, vitamins, and herbal products. Notable interactions include diuretics (water pills), potassium supplements, lithium, NSAIDs (such as ibuprofen, naproxen) and certain antidepressants (e.g., SSRIs, SNRIs).
Side Effects
Common side effects of Prestalia include:
- Cough
- Dizziness
- Swelling of the ankles or feet
- Headache
- Fatigue
Frequently Asked Questions about Prestalia
What should I do if I miss a dose of Prestalia?
If you miss a dose, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Can I drink alcohol while taking Prestalia?
Alcohol can increase certain side effects of Prestalia, such as dizziness and light-headedness. It's best to limit or avoid alcoholic beverages while using this medication.
How long does it take for Prestalia to start working?
Prestalia starts lowering blood pressure within hours of the first dose, but it may take several weeks to achieve maximum effectiveness.
Is Prestalia safe during pregnancy?
No, Prestalia is not recommended during pregnancy, particularly in the second and third trimesters, as it can harm the fetus. If you become pregnant while taking Prestalia, contact your healthcare provider immediately.
Can I drive or operate heavy machinery while taking Prestalia?
Prestalia can cause dizziness, especially after the first dose or when the dose is increased. It is advisable to know how you react to the medication before driving or operating heavy machinery.
How should I store Prestalia?
Store Prestalia at room temperature away from moisture and heat. Keep all medications out of the reach of children.
What should I avoid while taking Prestalia?
Avoid potassium supplements and salt substitutes containing potassium unless approved by your doctor. Also, avoid getting up too fast from a lying or sitting position, as you may feel dizzy.
Can I stop taking Prestalia if I feel better?
Do not stop taking Prestalia without consulting your healthcare provider, even if you feel well. High blood pressure often has no symptoms.
What happens if I overdose on Prestalia?
An overdose of Prestalia can be dangerous. If you suspect an overdose, seek emergency medical attention immediately.
Does Prestalia interact with other blood pressure medications?
Yes, Prestalia can interact with other blood pressure medications, potentially increasing side effects or altering effectiveness. Always inform your healthcare provider about all the medications you are taking.
