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Privigen (Immune Globulin Intravenous [Human], 10% Liquid) is a ready-to-use intravenous immunoglobulin (IVIG) solution designed for the treatment of primary humoral immunodeficiency (PI) and chronic immune thrombocytopenic purpura (ITP) in adults. As a sterile, preservative-free solution composed of highly purified immunoglobulin G (IgG) antibodies, Privigen supports immune system function by offering immediate passive immunity. Patients and healthcare providers often seek to buy Privigen for its clinical efficacy, safety profile, and ease of administration. It is formulated with proline for improved stability and does not require refrigeration, enhancing convenience in a variety of clinical settings.
| Fact Table | |
|---|---|
| Formula | Not applicable (biologic product – mixture of IgG antibodies) |
| License | FDA approved |
| Bioavailability | ~100% (intravenous) |
| Legal status | Prescription only |
| Chemical Name | Immunoglobulin G (Human) |
| Elimination half-life | Approximately 25–35 days |
| Dosage (Strength) | 10% solution (100 mg/mL) |
| Pregnancy | Use with caution; consult healthcare provider |
| Brands | Privigen |
| Protein binding | High (IgG binds to Fc receptors and antigens) |
| PubChem CID | Not available (biologic product) |
| MedlinePlus | a610024 |
| ChEBI | 36080 |
| ATC code | J06BA02 |
| DrugBank | DB11061 |
| KEGG | D10324 |
| Routes of administration | Intravenous (IV) |
Privigen is administered via intravenous infusion under the supervision of a qualified healthcare professional. The dosing and frequency depend on the indication, patient weight, and individual response to therapy. For Privigen infusion in primary immunodeficiency, typical dosing ranges from 200 to 800 mg/kg every 3 to 4 weeks. In chronic ITP, an initial dose of 1 g/kg daily for two consecutive days is generally recommended. All patients should be monitored closely during and after infusion, especially during the initial administration.
Each milliliter of Privigen contains 100 mg of protein, of which at least 98% is human immunoglobulin G (IgG). The product also contains 250 mmol/L L-proline as a stabilizer and trace amounts of polysorbate 80. It has a pH of approximately 4.8 and an osmolality of 320 mOsm/kg. Privigen is free from preservatives and sucrose.
Before administering a Privigen infusion, it is critical to assess for potential risk factors such as renal impairment, thrombotic disorders, or a history of hypersensitivity reactions. Privigen may increase the risk of renal dysfunction and thrombosis, particularly in predisposed individuals. Patients should be adequately hydrated before infusion, and
Privigen is contraindicated in individuals with a history of anaphylactic or severe systemic reactions to human immunoglobulin products. Patients with selective IgA deficiency who have developed antibodies against IgA may be at increased risk for severe hypersensitivity reactions. As with all blood-derived products, Privigen should not be used in individuals with known hypersensitivity to any of its components.
Common side effects of Privigen may include:
Serious adverse reactions, though rare, include renal dysfunction, aseptic meningitis, hemolysis, and thromboembolic events. Patients should report any unusual symptoms promptly to their healthcare provider.
What is Privigen?
Privigen is an immune globulin intravenous (human) 10% liquid preparation that contains antibodies purified from human plasma. It's used to treat patients with primary immunodeficiency, immune thrombocytopenic purpura, and chronic inflammatory demyelinating polyneuropathy.
How does Privigen work?
Privigen provides passive immunity by increasing antibody levels in your bloodstream. These antibodies help your body fight infections and regulate immune responses in certain autoimmune conditions.
Who manufactures Privigen?
Privigen is manufactured by CSL Behring.
What conditions is Privigen approved to treat?
Privigen is FDA-approved for:
Primary Immunodeficiency (PI)
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Immune Thrombocytopenic Purpura (ITP)
How is Privigen administered?
Privigen is administered by intravenous (IV) infusion by healthcare professionals in a medical setting. It cannot be self-administered at home.
What is the typical dosage of Privigen?
Dosage varies by condition:
For PI: 200-800 mg/kg every 3-4 weeks
For ITP: 1 g/kg for 2 consecutive days
For CIDP: Loading dose of 2 g/kg followed by maintenance doses of 1 g/kg every 3 weeks
What are the most common side effects of Privigen?
Common side effects include headache, fatigue, nausea, chills, fever, pain, rash, and increased blood pressure.
What are the serious risks associated with Privigen?
Serious risks include:
Thrombosis (blood clots)
Renal dysfunction or failure
Aseptic meningitis syndrome
Hemolysis (destruction of red blood cells)
Transfusion-related acute lung injury
Severe allergic reactions
Does Privigen carry a boxed warning?
Yes. Privigen carries a boxed warning for thrombosis, renal dysfunction, and acute renal failure.
Is Privigen safe during pregnancy?
Privigen has not been evaluated in pregnant women. It should be given during pregnancy only if clearly needed. Discuss risks and benefits with your healthcare provider.
How long does a Privigen infusion take?
Initial infusions typically take 2-4 hours. Subsequent infusions may be administered at a faster rate if well tolerated, but this varies by patient and condition.
How should Privigen be stored?
Privigen should be stored at room temperature (up to 25°C/77°F) for up to 36 months from the date of manufacture. Do not freeze.
Can I receive vaccines while on Privigen?
Immune globulin products like Privigen can reduce the effectiveness of certain vaccines, particularly live vaccines. Consult your healthcare provider about proper vaccination timing.
How is Privigen different from subcutaneous immune globulin products?
Privigen is administered intravenously, while subcutaneous products are injected under the skin. IV administration typically requires less frequent dosing but must be done in a healthcare setting.
Is Privigen covered by insurance?
Coverage varies by insurance plan. Most insurance providers cover Privigen for FDA-approved indications, but prior authorization may be required.
Does Privigen contain IgA?
Yes, Privigen contains trace amounts of IgA (=25 mcg/mL). Patients with IgA deficiency may be at risk for developing anti-IgA antibodies and should discuss this with their doctor.
