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Rofact (rifampin)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Rifampin belongs to the class of medications called antibiotics. It is used with other medications to treat tuberculosis infection in the lungs. It may also be used to prevent meningitis caused by specific bacteria or to prevent carrying the bacteria when exposed to someone with bacterial meningitis. Rifampin works by interfering with the production of genetic material needed for the bacteria to reproduce. It reduces the production of more bacteria as well as killing the bacteria.

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The usual adult dose of rifampin to treat tuberculosis is 600 mg taken once daily. Doses for children are based on body weight and calculated as 10 mg to 20 mg per kilogram of body weight to a maximum of 600 mg daily. Rifampin is taken along with at least one other anti-tuberculosis medication until your doctor has determined that the infection has cleared. To prevent bacterial meningitis, rifampin is taken as 600 mg every 12 hours for 2 days or 600 mg daily for 4 days, depending on the type of bacteria that is believed to cause the infection. Doses for children are based on body weight. Rifampin should be taken on an empty stomach, 1 hour before or 2 hours after meals. Finish all this medication, even if you have started to feel better. If you stop taking this medication early, the infection may return and be harder to treat. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children. Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.


The active ingredient in Rofact is rifampin.


Antibiotic-related diarrhea: As with other antibacterial medications, rifampin can cause a severe form of diarrhea associated with a condition known as pseudomembranous colitis. If you develop severe diarrhea while taking (or within a few weeks of taking) this medication, contact your doctor. Bacterial resistance: Misuse of an antibiotic such as rifampin may lead to the growth of resistant bacteria that will not be killed by the antibiotic. If this happens, the antibiotic may not work for you in the future. Although you may begin to feel better when you first start taking rifampin, you need to take all the medication exactly as prescribed by your doctor to finish ridding your body of the infection and to prevent resistant bacteria from taking hold. Do not take rifampin or other antibiotics to treat a viral infection such as the common cold; antibiotics do not kill viruses, and using them to treat viral infections can lead to the growth of resistant bacteria. Birth control: Rifampin can reduce the effectiveness of hormonal birth control, which may lead to unplanned pregnancy. Women who may become pregnant while taking rifampin should use another or a second method of birth control. Hypersensitivity syndrome: A severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of rifampin. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering. Red-orange discolouration: Rifampin causes substances produced by the body, such as stools, urine, tears, and sweat, to be coloured red-orange. This discolouration can cause contact lenses to become permanently stained. Liver function: Rifampin can cause liver failure, which has in some cases caused death. This may be more likely to occur if you already have decreased liver function. Liver disease or reduced liver function may also cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately. Porphyria: Rifampin may cause attacks of a condition called acute porphyria (a disorder that affects the production of heme in the body). If you have porphyria, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Pregnancy: This medication crosses the placental barrier, but its effect on a developing baby is not clear. Rifampin should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking rifampin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. Children: Rifampin should not be given to premature infants or newborns, as the liver may not be fully active.

Side Effects

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time. • Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. • abdominal cramps • diarrhea • dizziness • drowsiness • fatigue • flushing • headache • heartburn • irregular menstrual periods • itchiness • loss of appetite • nausea • reddish-orange discolouration of sweat, tears, urine • skin flushing • skin rash • sore mouth or tongue • tooth discolouration • vomiting Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention. Check with your doctor as soon as possible if any of the following side effects occur: • confusion • difficulty concentrating • flu-like symptoms (e.g., fever, chills, dizziness, difficulty breathing, unusual arm or leg pain) • hallucinations • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding) • signs of kidney problems (e.g., decreased urine production, swelling, fatigue, abdominal pain) • symptoms of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath) • symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools) • vision changes Stop using the medication and seek immediate medical attention if any of the following occur: diarrhea (watery and severe; may also be bloody) • shortness of breath or wheezing • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat) • signs of a severe skin reaction (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort) • sudden, severe headaches