Saizen (Somatropin)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C990H1528N262O300S7 |
| License | FDA approved |
| Bioavailability | Subcutaneous: 70-90% |
| Legal status | Prescription only |
| Chemical Name | Somatropin |
| Elimination half-life | Subcutaneous: 2.1 to 3.8 hours |
| Dosage (Strength) | 5 mg, 8.8 mg, 12 mg |
| Pregnancy | Consult a doctor |
| Brands | Saizen, Humatrope, Norditropin, Genotropin |
| Protein binding | Weak (GHBP) |
| PubChem CID | 16132233 |
| MedlinePlus | a608034 |
| ChEBI | 106736 |
| ATC code | H01AC01 |
| DrugBank | DB00052 |
| KEGG | D00894 |
| Routes of administration | Subcutaneous, Intramuscular |
Saizen is a synthetic version of the human growth hormone (hGH), prescribed for the treatment of growth hormone deficiency and certain conditions leading to short stature and growth failure. Manufactured through recombinant DNA technology, Saizen mimics the natural growth hormone produced by the pituitary gland, facilitating normal growth and development in children and adults lacking sufficient natural growth hormone.
Before you buy Saizen, it is crucial that you talk to your healthcare provider about potential side effects and Saizen cost.
Directions
Begin with a consultation with your healthcare provider to ensure Saizen is appropriate for your condition.
Saizen must be prescribed by a healthcare professional.
Follow the specific instructions for reconstitution and administration provided by your healthcare provider. Saizen is typically administered via subcutaneous injection. The Saizen dosage and frequency of administration will be determined based on individual requirements, including age, weight, and the condition being treated.
Regular follow-ups with your healthcare provider are necessary to monitor growth progress, adjust dosages as needed, and check for side effects.
Ingredients
Active Ingredient: Somatropin
Cautions
Patients with known sensitivity to somatropin or any of the excipients in Saizen should not use this medication.
Individuals with active malignancy, acute critical illness, or diabetic retinopathy should avoid Saizen therapy. Caution is advised in patients with a history of intracranial hypertension, hypothyroidism, or underlying adrenal insufficiency.
The safety of Saizen during pregnancy and lactation has not been established. Use only if clearly needed and after a thorough risk-benefit analysis.
Interactions
Glucocorticoids: Concurrent use may inhibit the growth-promoting effects of Saizen.
Insulin and Oral Hypoglycemics: Saizen may affect glucose tolerance; monitor blood glucose levels closely in patients with diabetes or those using insulin or oral hypoglycemic agents.
Cytochrome P450-Metabolized Drugs: Although specific interactions have not been documented, Saizen may potentially alter the metabolism of substances processed by the liver.
Side Effects
While Saizen is effective in treating growth hormone deficiencies, it may cause side effects in some patients. Common side effects include:
- Injection site reactions
- Headache
- Joint pain
- Muscle pain
- Fluid retention, leading to swelling of the hands and feet
Frequently Asked Questions about Saizen (Somatropin)
What is Saizen (Somatropin)?
Saizen is a brand of somatropin, a growth hormone used to treat children and adults with growth hormone deficiency.
How is Saizen produced?
The growth hormone (somatropin) contained in Saizen is almost the same as a human’s natural growth hormone except that it is made outside the body by a process called “recombinant DNA technology” (genetic engineering).
In what forms is Saizen available?
Saizen is available as a lyophilized powder for reconstitution and as a solution for injection in a cartridge.
Who can use Saizen?
Saizen is used to treat children and adolescents with growth hormone deficiency. It is also used to treat adults with growth hormone deficiency.
What are the clinical uses of Saizen?
Saizen is used to increase growth in children and adolescents and to treat adults with growth hormone deficiency.
How is Saizen administered?
Saizen is administered through injection.
Are there any eHealth tools associated with Saizen?
Yes, Saizen has a unique selection of eHealth tools that enable healthcare professionals to support patients along their treatment journey.
What are the potential side effects of Saizen?
As with any medication, Saizen may have side effects. It’s important to discuss these potential side effects with your healthcare provider.
Where can I get more information about Saizen?
More information about Saizen can be obtained from the product monograph or your healthcare provider.
What should I do if I experience an adverse event while using Saizen?
If you experience an adverse event while using Saizen, you should immediately report it to your healthcare provider.
