Siklos (Hydroxyurea)
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Description
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Fact Table
| Fact Table | |
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| Formula | CH4N2O2 |
| License | US FDA, EU EMA |
| Bioavailability | 79% |
| Legal status | Prescription Required |
| Chemical Name | Hydroxyurea |
| Elimination half-life | 2–4 hours |
| Dosage (Strength) | 100mg |
| Pregnancy | Consult Doctor |
| Brands | Siklos |
| Protein binding | More than 76% |
| PubChem CID | 3657 |
| MedlinePlus | a682004 |
| ChEBI | 44423 |
| ATC code | L01XX05 |
| DrugBank | DB01005 |
| KEGG | D00341 |
| Routes of administration | By mouth |
SIKLOS is a prescribed medication used to decrease the frequency of painful episodes and minimize the requirement for blood transfusions in adults and children (2 years and older) diagnosed with sickle cell anemia. It is specifically intended for individuals experiencing recurrent moderate to severe painful crises associated with the condition.
Directions
You can buy Siklos in 1000mg and 100 mg tablets.
The initial dose of Siklos is 20 mg per kilogram of body weight and can be adjusted as necessary.
If bone marrow suppression occurs, the use of Siklos should be stopped until blood counts improve and reach an acceptable level.
It is important not to discontinue Siklos or alter the dosage without consulting your doctor.
Ingredients
The active ingredient is Hydroxyurea.
Cautions
If you have a history of kidney problems or impaired kidney function, the dosage of the medication may need to be adjusted.
It is important to avoid sun exposure or wear suitable protective clothing and sunscreen when using this medication.
Healthcare professionals should closely monitor bone marrow function during treatment with this medication.
This medication can be harmful to a developing fetus, so it is crucial to use appropriate contraception while taking the drug.
This medication can cause a temporary decrease in the white blood cell count in your bloodstream, which can increase the risk of developing an infection.
Interactions
This drug could have negative interactions with Abrocitinib, Baricitnib, BCG (Intravesical), Cladribine, Dengue tetravalent vaccine, Didanosine, Dipyrone, Fexinidazole, Natalizumab, Pimecrolimus, Poliovirus vaccine, Rubella vaccine, Ruxolitinib, Stavudine, Tacrolimus, Talimogene, Tertomotide, Tofacitinib, Typhoid vaccine, Upadacitinib, Varicella vaccine and yellow fever vaccine. It is important to consult with your doctor before taking any other medications to ensure they are safe to use in combination with hydroxyurea.
Side Effects
The common side effects of hydroxyurea for sickle cell include nausea, vomiting, diarrhea, decreased appetite, weight gain, mouth and throat sores, constipation, rash, pale skin, dizziness, headache, hair loss, and changes in skin and nails. If you experience any of these symptoms, it is important to inform your doctor.
Frequently Asked Questions about Medunik
What should I avoid while taking hydroxyurea?
While taking hydroxyurea:
- Avoid pregnancy and breastfeeding.
- Avoid receiving live vaccines while on this treatment.
- Refrain from donating blood for at least 6 months after stopping the medication.
- Limit or avoid alcohol consumption.
- Take precautions to avoid exposure to infections as hydroxyurea may weaken the body's immune response.
Is hydroxyurea a chemotherapy?
Yes, hydroxyurea is a type of chemotherapy medication. It is used in the treatment of certain types of cancers (such as leukemia) as well as sickle cell disease.
Why can't you touch hydroxyurea?
Hydroxyurea is a medication that can be harmful if it comes into direct contact with the skin. It is important to avoid touching hydroxyurea to prevent any potential harm or absorption of the medication through the skin. Using gloves or other protective measures when handling hydroxyurea is recommended to ensure safety.
How long can you stay on hydroxyurea?
Hydroxyurea can be prescribed for either short-term or long-term use. Hydroxyurea can be used safely for long-term treatment and the duration of treatment will depend on the individual's condition and response to the medication.
How long does it take for hydroxyurea to lower platelets?
Hydroxyurea is typically effective in reducing platelet counts within a few weeks, and it generally has minimal short-term side effects.
