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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
SIKLOS is a prescribed medication used to decrease the frequency of painful episodes and minimize the requirement for blood transfusions in adults and children (2 years and older) diagnosed with sickle cell anemia. It is specifically intended for individuals experiencing recurrent moderate to severe painful crises associated with the condition.
| Fact Table | |
|---|---|
| Formula | CH4N2O2 |
| License | US FDA, EU EMA |
| Bioavailability | 79% |
| Legal status | Prescription Required |
| Chemical Name | Hydroxyurea |
| Elimination half-life | 2–4 hours |
| Dosage (Strength) | 100mg |
| Pregnancy | Consult Doctor |
| Brands | Siklos |
| Protein binding | More than 76% |
| PubChem CID | 3657 |
| MedlinePlus | a682004 |
| ChEBI | 44423 |
| ATC code | L01XX05 |
| DrugBank | DB01005 |
| KEGG | D00341 |
| Routes of administration | By mouth |
You can buy Siklos in 1000mg and 100 mg tablets.
The initial dose of Siklos is 20 mg per kilogram of body weight and can be adjusted as necessary.
If bone marrow suppression occurs, the use of Siklos should be stopped until blood counts improve and reach an acceptable level.
It is important not to discontinue Siklos or alter the dosage without consulting your doctor.
The active ingredient is Hydroxyurea.
If you have a history of kidney problems or impaired kidney function, the dosage of the medication may need to be adjusted.
It is important to avoid sun exposure or wear suitable protective clothing and sunscreen when using this medication.
Healthcare professionals should closely monitor bone marrow function during treatment with this medication.
This medication can be harmful to a developing fetus, so it is crucial to use appropriate contraception while taking the drug.
This medication can cause a temporary decrease in the white blood cell count in your bloodstream, which can increase the risk of developing an infection.
This drug could have negative interactions with Abrocitinib, Baricitnib, BCG (Intravesical), Cladribine, Dengue tetravalent vaccine, Didanosine, Dipyrone, Fexinidazole, Natalizumab, Pimecrolimus, Poliovirus vaccine, Rubella vaccine, Ruxolitinib, Stavudine, Tacrolimus, Talimogene, Tertomotide, Tofacitinib, Typhoid vaccine, Upadacitinib, Varicella vaccine and yellow fever vaccine. It is important to consult with your doctor before taking any other medications to ensure they are safe to use in combination with hydroxyurea.
The common side effects of hydroxyurea for sickle cell include nausea, vomiting, diarrhea, decreased appetite, weight gain, mouth and throat sores, constipation, rash, pale skin, dizziness, headache, hair loss, and changes in skin and nails. If you experience any of these symptoms, it is important to inform your doctor.
What should I avoid while taking hydroxyurea?
While taking hydroxyurea:
Is hydroxyurea a chemotherapy?
Yes, hydroxyurea is a type of chemotherapy medication. It is used in the treatment of certain types of cancers (such as leukemia) as well as sickle cell disease.
Why can't you touch hydroxyurea?
Hydroxyurea is a medication that can be harmful if it comes into direct contact with the skin. It is important to avoid touching hydroxyurea to prevent any potential harm or absorption of the medication through the skin. Using gloves or other protective measures when handling hydroxyurea is recommended to ensure safety.
How long can you stay on hydroxyurea?
Hydroxyurea can be prescribed for either short-term or long-term use. Hydroxyurea can be used safely for long-term treatment and the duration of treatment will depend on the individual's condition and response to the medication.
How long does it take for hydroxyurea to lower platelets?
Hydroxyurea is typically effective in reducing platelet counts within a few weeks, and it generally has minimal short-term side effects.
