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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Sovaldi or Harvoni with the generic name Sofosbuvir is a type of antiviral medication that contains the Hepatitis C virus and keeps it from multiplying in the body. It is developed by Gilead Sciences Inc. It is normally used in combination with other medicines for the treatment of genotypes 1 chronic Hepatitis C in adults and kids who are at least three years old.
It must be taken in combination with other antiviral medicines and is not to be used alone. Sovaldi or Harvoni is typically given with ribavirin, with or without peginterferon alfa. These medications do not guarantee that it can prevent you from contaminating others.
Harvoni or sofosbuvir is also sometimes prescribed for people with HIV, people with liver cancer and those going to have a liver transplant. However, this medication is not considered as a treatment for HIV.
People who had Hepatitis B should be cautious in taking Sovaldi medication. Hep B can recur or get worse with this medication. Frequent blood tests will be needed to monitor proper liver function.
Before you start taking Sovaldi, read and understand the patient information leaflet that comes with the medication. If you don't understand some details, ask your doctor or pharmacist to get clear answers.
The recommended dosage for adults is 400 mg tablets taken orally once every day. It can be taken with or without food. It may be administered in combination with ribavirin or pegylated interferon and ribavirin to treat HCV. The recommended treatment duration and regimen for a combination of medication will be discussed by your doctor or pharmacist.
Sovaldi works best when there is a constant level of the drug in your body. Thus, it should be taken at an even space interval or you have to take your medication at the same time every day.
Be sure to continue taking Sovaldi and your combination medications for the whole length of your treatment plan. Do this even if the symptoms disappear after a short period. Stopping your medication without prior advice from your doctor may result in the reactivation of infection.
Likewise, a dosage reduction of Sofosbuvir is not recommended. If you experience adverse side effects related to combination drugs ribavirin and peginterferon alfa, the combination of drugs may be reduced or discontinued per the advice of your doctor. If appropriate, until the reactions subside in severity. Likewise, if the other medications used in combination with Sovaldi are discontinued permanently, then Sovaldi should also be discontinued.
When taking Sovaldi or sofosbuvir and you miss a dose, take it as soon as you remember. If it is close to your next dose, don't take the missed one. Take the next dose at its regular time and do not double dose to catch up if the timing is close to the next.
Likewise, get your prescription refilled before you run out of medication.
Active ingredients include Sofosbuvir Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, mannitol, and microcrystalline cellulose.
There are many potential drugs that may interfere with Sovaldi, thus you should keep a list of all the products you use such as herbal supplements, prescription, and non-prescription medications. Share your list with your doctor so that they can check and advise you to stop, start or change your medication dosage.
Some medications that cause interaction with Sovaldi are:
Thus, these medications should be stopped when you start taking Sofosbuvir.
Before starting treatment using Sofosbuvir medication, you should inform your health care worker if you have any allergies to medicines. Patients with specific medical conditions such as previous hepatitis B virus infection or kidney diseases should inform their doctor or pharmacist.
Patients with diabetes may further lower their blood sugar levels with hepatitis C virus medications. It can increase their risk of low blood sugar; thus your doctor should be informed of potential adjustment in your diabetes treatment plan. If you experience symptoms such as shaking, sweating, hunger, fast heartbeat, dizziness, tell your doctor right away.
The use of this medication during pregnancy should only be when absolutely necessary. Sovaldi in combination with peginterferon or ribavirin should not be taken during pregnancy by the pregnant woman or male partner. This combination can cause harm or even be fatal to an unborn baby. It is advised to use two reliable birth control methods when one partner is using these combinations of medication and until six months after finishing the treatment plan. If you or your partner becomes pregnant, inform your doctor immediately.
More so, it is still unknown whether this medication is passed on to breast milk. Yet, breastfeeding while under medication using Sovaldi in combination with peginterferon or ribavirin is not advised.
The use of Sofosbuvir can cause a range of mild to serious side effects. These side effects manifest differently for each patient. For more information on the potential side effects of this medication, consult with your doctor or pharmacist.
Some of the most common side effects of taking Sovaldi in combination with ribavirin and pegylated interferon include the following:
If there are more severe or if the side effects don't go away, consult with your doctor on how to handle them. It is rare to experience serious side effects while on Sovaldi medication, but it can happen. Consult with your doctor right away if you experience serious side effects. If you have severe side effects that you feel are life-threatening or are a medical emergency, call 911. Hepatitis B virus reactivation and severe allergic reaction are some of the serious side effects of Sovaldi.
If you are wondering how often these side effects happen as you take Sovaldi, here are some details that you must know.
Similar to other medications, people may develop allergic reactions after using Sovaldi. Though there are no reports of allergic reactions in clinical trials, you can expect some mild reactions such as itchiness, skin rash and flushing.
More severe allergic reactions are possible but are rare. Symptoms severe allergies to look-out for include trouble breathing, swelling under the skin such as lops, eyelids, feet, and hands, and swelling of the tongue, throat, and mouth.
If you experience any symptoms of a severe allergic reaction call your doctor as soon as possible. If you feel that you are having a medical emergency or your symptoms are life-threatening, call 911 immediately.
After a treatment plan that involves the use of Sovaldi, the patient needs regular check-up to monitor the status of your liver. Your doctor may conduct some blood tests for this check.
It is crucial to conduct liver function monitoring after having treatment for HCV or hep C virus. Patients may still have lingering liver damage even after completing treatment. Any worries that you may have after your treatment should be disclosed with your doctor. They will help you monitor signs of liver problems that may happen after Sovaldi treatment.
These are the details of the most common side effects that patients experience with Sovaldi.
Fatigue - feeling tired and lacking in energy is a potential side effect of Sofosbuvir medication. If you are taking this drug, you might feel more tired than usual. Talk with your doctor or pharmacist on how you can manage this side effect.
Headaches - during trials, about 24 percent of the patients taking the Sovaldi and ribavirin combination for three months experienced constant headaches. Additionally, 36 percent of those taking the drug trio of Sovaldi, pegylated interferon and ribavirin experienced this side effect. If your headaches are becoming bothersome while you are on a Sovaldi medication, consult with your doctor on how to improve this condition.
HBV Reactivation - this condition can happen during or after your treatment of the hepatitis C virus if you are diagnosed with both hepatitis B and hepatitis C in your body. It is one of the most severe side effects that can come with this medication.
When HBV reactivation happens, there is a flare-up of the hep B virus. Some symptoms of this condition include yellowing of your skin and whites of the eyes and pain in the abdomen. HBV reactivation has happened to patients using drugs under the same class of medication as Sovaldi. Thus, there is a high-risk of the hep B virus flare-up.
Therefore, it is crucial to run some tests for HBV before a patient starts HCV medication with Sovaldi. In case you have both the HBV and HCV in your body, you may need more frequent liver function monitoring during the course of your Sovaldi treatment.
If a person has overdosed on Sovaldi or sofosbuvir and displays serious symptoms like trouble breathing or passing out, take them to the emergency room or call 911. You may also contact the poison control center in your locality.
Sovaldi or sofosbuvir medications should be stored at room temperature and away from light in moisture. It should be kept in its original container and away from children and pets.
To dispose of excess medication, do not flush down the toilet or pour into a drain unless given instruction by a health care worker. Consult your pharmacist or your local waste disposal agent on how you can properly discard products that are no longer needed or are already expired.
Sovaldi or generic sofosbuvir is a medication for treating hep C virus infection. It is recently approved for use for treating adults and children three years and older with all genotypes of chronic hepatitis C virus. It is typically prescribed and used in combination therapy with other medications ribavirin, and peginterferon alfa.
The cost of Sovaldi drugs can vary depending on your insurance plan, location and the pharmacy from where you purchase it. Typically the medication costs about $1000 per 400mg pill. The minimum treatment plan takes 12 to 24 weeks and doctors will prescribe it in combination with other medicines such as ribavirin and peginterferon.
Sovaldi or Harvoni is a medication used in combination with other drugs to treat chronic hepatitis C infection It is usually prescribed with ribavirin, and peginterferon alfa.
Sovaldi developed by Gilead Sciences Inc was approved by the FDA in 2013 to treat adults with chronic hepatitis C infection. In 2016, it was approved for the treatment of HCV infection in children three years old and older.
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Sofosbuvir |
|
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DrugBank |
DB08934 |
|
PubChem CID |
45375808 |
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CAS Number |
1190307-88-0 |
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ChEMBL |
ChEMBL1259059 |
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ChemSpider |
26286922 |
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UNII |
WJ6CA3ZU8B |
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KEGG |
D10366 |
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ChEBI |
CHEBI:85083 |
