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Stivarga (Regorafenib)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Stivarga is an oral multi-kinase inhibitor medication primarily used in the treatment of certain types of cancers. This drug functions by interfering with the growth and spread of cancer cells in the body. Stivarga is prescribed for patients with colorectal cancer, gastrointestinal stromal tumors, and liver cancer, especially when the cancer has spread to other parts of the body and other treatments have not been effective.

Before you buy Stivarga for the treatment of cancer, it is crucial that you talk to your healthcare provider about potential side effects and Stivarga cost.

Buy Stivarga (Regorafenib) online from online Canadian Pharmacy |


Always take Stivarga as prescribed by your doctor. The recommended dose is one 160 mg tablet (four 40 mg tablets) once daily.

Before starting the medication, thoroughly review the Stivarga package insert to understand the dosage and potential side effects.

Consume the tablets with a low-fat breakfast that contains less than 30% fat content. Taking Stivarga on an empty stomach can increase its effects.

Stivarga is taken for 21 days, followed by a 7-day break, making a complete cycle of 28 days. Your doctor may adjust this based on your response to treatment.


Active Ingredient: Regorafenib


Before starting treatment, inform your doctor about any existing health conditions and medications you're taking, including over-the-counter drugs, vitamins, and herbal supplements.

Pregnant or breastfeeding mothers should consult their doctors before starting Stivarga. It may harm the unborn baby or be passed in breast milk.

Avoid grapefruit or grapefruit juice during the treatment as it might increase Regorafenib levels in the body.

Limit exposure to sunlight as Stivarga can make your skin sensitive, increasing the risk of sunburn.


When combined with anticoagulant drugs, Stivarga might elevate the likelihood of bleeding. Additionally, medications that restrain CYP3A4 have the potential to amplify Regorafenib concentrations, which may heighten the risk of toxic effects. On the other hand, medications that activate CYP3A4 could reduce Regorafenib concentrations, possibly diminishing its effectiveness. It is crucial to keep an updated record of all the medicines you are on and communicate this list to your medical professional.

Side Effects

Common side effects include:

  • Fatigue
  • Loss of appetite
  • Hand-foot syndrome (redness, pain, swelling of hands or feet)
  • Diarrhea
  • Mouth sores
  • Weight loss
  • Infection

Remember, these are not exhaustive lists, and it's important to consult with a healthcare professional for personalized advice and guidance. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit or call 1-800-FDA-1088

Frequently Asked Questions about Stivarga

Is Stivarga a last resort?

While Stivarga is often prescribed when other treatments are ineffective, it doesn't mean it is a last resort. It is a part of a comprehensive cancer treatment plan tailored for individual patients.

Can Stivarga cure cancer?

Stivarga is designed to slow or stop the growth of certain cancer cells. While it can significantly improve the quality of life and prolong survival, it is not considered a cure.

How long does Stivarga stay in your system?

Regorafenib has a half-life of about 28 hours. It takes approximately 5-6 half-lives for a drug to be eliminated from your system. Thus, Stivarga might stay in your system for around 5-7 days.

How long can you take Stivarga?

The duration varies depending on the patient's response and the development of side effects. Some patients might take it for several months, while others might use it for years.

Is Stivarga chemotherapy?

Yes, Stivarga is a form of targeted chemotherapy. Unlike traditional chemotherapy, which affects all rapidly dividing cells, targeted therapies like Stivarga specifically act on certain molecular targets associated with cancer.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.