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Tolsura (Itraconazole)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Tolsura, which contains itraconazole, is an azole antifungal medication used to treat specific fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It exerts its action by disrupting the fungal cell membrane, thereby inhibiting fungal growth.

Before you buy Tolsura, it is essential to consult with your healthcare professional to determine if it is the appropriate medication for your specific fungal infection, its effectiveness and Tolsura price.

Fact Table
Formula C35H38Cl2N8O4
License FDA-Approved
Bioavailability ~55%
Legal status Prescription drug
Chemical Name Itraconazole
Elimination half-life 21 hours
Dosage (Strength) 65mg
Pregnancy Consult a doctor
Brands Tolsura
Protein binding 99.8%
PubChem CID 55283
MedlinePlus a692049
ChEBI 6076
ATC code J02AC02
DrugBank DB01167
KEGG D00350
Routes of administration By mouth

Buy Tolsura (Itraconazole) online from online Canadian Pharmacy |


Take this medication orally with food, as instructed by your doctor, usually once or twice daily. Swallow the capsules whole; do not chew, crush, or break them. Make sure you take Tolsura 65 mg at consistent intervals throughout the day, at the same time for optimal effectiveness. Continue taking the medication until you have finished the full prescribed amount, even if your symptoms improve after a few days. Stopping Tolsura suddenly can cause the infection to come back.


The active ingredient in Tolsura is Itraconazole.


Before taking itraconazole, inform your doctor if you are allergic to it.

Share your medical history, especially if you have liver problems, kidney problems, heart problems, or lung disease.

Itraconazole may cause dizziness, and alcohol or marijuana can intensify this effect. Avoid driving, using machinery, or activities requiring alertness.

Using this medication may increase the risk of hearing loss in older adults.

Use itraconazole during pregnancy only, if necessary, as it may harm the unborn baby. Discuss the risks and benefits with your doctor and use reliable birth control methods.

Before breastfeeding, it is important to consult with your doctor as itraconazole can pass into breast milk.


This medication could have negative interactions with digoxin, fluticasone, metformin, sitagliptin, atorvastatin, macitentan, sertraline, phenytoin, efavirenz, isoniazid, nevirapine, rifabutin amongst others. Inform your doctor about all the medications you use before starting your treatment with Tolsura.

Side Effects

The common side effects with Tolsura capsules are nausea, vomiting, diarrhea, headache, stomach upset, or dizziness.

Frequently Asked Questions about Tolsura

What is Tolsura capsule used for?

Tolsura capsules are used to treat certain fungal infections, including histoplasmosis, aspergillosis, and blastomycosis.

What is the difference between Sporanox and Tolsura?

Tolsura and Sporanox are both capsule medications that contain the azole antifungal itraconazole. However, they have different strengths and formulations, and they cannot be swapped or used interchangeably. It's important to note that Tolsura is not meant to be used for treating onychomycosis (fungal infection of the toenail or fingernail caused by dermatophytes), while Sporanox is specifically indicated for that purpose.

What class of drug is Tolsura?

Tolsura contains itraconazole which belongs to a class of drugs known as azole antifungals. It is primarily used for treating fungal infections, including those affecting the lungs, nails, and skin.

Who is the manufacturer of Tolsura?

The manufacturer of Tolsura is Mayne Pharma International Pty Ltd.

How long does itraconazole stay in your system?

After your last dose of Itraconazole, the medication begins to leave your body within 1 to 2 days. However, trace amounts of it can still be detected in your bloodstream for up to 14 days.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.