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Trijardy XR (Empagliflozin/Linagliptin/Metformin HCI)

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Trijardy XR is a medication used for the treatment of type 2 diabetes. It is a combination of three active ingredients: empagliflozin, linagliptin, and metformin hydrochloride. Empagliflozin functions by inhibiting the kidney's glucose reabsorption, leading to elevated glucose excretion in the urine and decreased blood sugar levels. Linagliptin helps to increase the levels of incretin hormones in the body, which stimulate the release of insulin and reduce the production of glucose by the liver. Metformin operates by decreasing liver glucose production and enhancing insulin sensitivity, enabling improved utilization of insulin by the body.

Trijardy XR combines the actions of these three medications to help control blood sugar levels in individuals with type 2 diabetes. It is typically prescribed along with a healthy diet and regular exercise. When evaluating treatment options for type 2 diabetes, it is essential to consider factors such as effectiveness and the Trijardy XR price.

What is type 2 diabetes?

Type 2 diabetes is a chronic metabolic condition characterized by elevated levels of glucose in the blood. It is the most common form of diabetes and usually develops in adulthood, although it can also occur in children and adolescents. In type 2 diabetes, the body either develops resistance to insulin, preventing it from working effectively, or it doesn't produce enough insulin to regulate blood sugar levels within the normal range.

Fact Table
Formula C24H25FO5S
License FDA-approved
Bioavailability 65%
Legal status Prescription drug
Chemical Name Empagliflozin/Linagliptin/Metformin HCI
Elimination half-life 10–13 hours
Dosage (Strength) 12.5mg / 2.5mg / 1000mg, 5mg / 2.5mg / 1000mg, 10mg / 5mg / 1000mg, 25mg / 5mg / 1000mg
Pregnancy Not recommended
Brands Trijardy XR
Protein binding 99%
PubChem CID 24812758
MedlinePlus a613033
ChEBI 73274
ATC code A10BK02
DrugBank DB08907
KEGG D09592
Routes of administration Inhalation

Buy Trijardy XR (Empagliflozin/Linagliptin/Metformin HCI) online from online Canadian Pharmacy |


The dosage and directions for Trijardy XR may vary depending on individual response and blood sugar control. Before you buy Trijardy XR talk to your healthcare provider and have them determine the most appropriate dose for you.

Take Trijardy XR by mouth once daily, preferably with breakfast. The recommended dosage is as follows:

  • You can take either one tablet of Trijardy XR 10 mg/5 mg/1000 mg or Trijardy XR 25 mg/5 mg/1000 mg once daily.
  • Alternatively, you can take two tablets of Trijardy XR 5 mg/2.5 mg/1000 mg or Trijardy XR 12.5 mg/2.5 mg/1000 mg together once daily.

The tablets should be swallowed whole and should not be crushed, chewed, or split.

It is important to adhere to the prescribed dosage and not exceed or miss any doses.


Trijardy XR is a combination of three active ingredients: empagliflozin, linagliptin, and metformin hydrochloride.


Inform your doctor about your medical history and allergies you may have.

Trijardy XR can affect your blood sugar levels, which may cause blurred vision, dizziness, or drowsiness.

It's best to reduce alcohol intake while taking Trijardy XR. Alcohol can raise the chances of lactic acidosis, low blood sugar, or high ketone levels.

Unless instructed otherwise by your doctor, make sure to stay adequately hydrated by consuming enough of fluids.


This medication may have negative drug interactions with amlodipine, enalapril, glimepiride, jardiance (empagliflozin), lisinopril, losartan, metformin, metoprolol, metoprolol succinate ER (metoprolol), tamsulosin.

Side Effects

The most common Trijardy XR side effects are urinary tract infections, genital yeast infections, increased urination, hypoglycemia, nausea and vomiting, diarrhea, and upper respiratory tract infections.

Frequently Asked Questions about Trijardy XR

What is Trijardy used for?

Trijardy XR is a medication used to treat type 2 diabetes in adults. It combines empagliflozin, linagliptin, and metformin to help lower blood sugar levels through increased glucose excretion, improved insulin release, and reduced liver glucose production.

Does Trijardy contain metformin?

Trijardy XR contains Metformin, which functions by diminishing liver glucose production and enhancing insulin sensitivity, enabling the body to utilize insulin more efficiently.

Does Trijardy XR cause weight loss?

Weight loss can be a potential side effect of Trijardy XR, although it's not guaranteed to occur in every individual. The weight loss associated with Trijardy XR is primarily attributed to empagliflozin, which works by reducing the reabsorption of glucose by the kidneys, leading to increased glucose excretion in the urine. This mechanism can result in a modest reduction in body weight for some people.

Does Trijardy make you tired?

Trijardy XR, like any medication, can potentially cause side effects, and fatigue or tiredness can be one of them. However, it's important to note that not everyone will experience these side effects, and the severity and frequency can vary from person to person.

How often do you take Trijardy?

Trijardy XR is taken once daily, preferably with breakfast. However, it's important to follow the specific instructions provided by your healthcare provider and the medication's prescribing information.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.