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Fact Table
| Fact Table | |
|---|---|
| Formula | C18H22N2S |
| License | FDA and EMA approved (2013) |
| Bioavailability | ~75% (oral) |
| Legal status | Prescription only (Rx) |
| Chemical Name | 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
| Elimination half-life | ~66 hours |
| Dosage (Strength) | 5 mg, 10 mg, 20 mg oral tablets (once daily) |
| Pregnancy | Limited human data – use if benefit outweighs risk |
| Brands | Trintellix (formerly Brintellix) |
| Protein binding | ~98% |
| PubChem CID | 9966056 |
| MedlinePlus | a614003 |
| ChEBI | 135847 |
| ATC code | N06AX26 |
| DrugBank | DB09068 |
| KEGG | D10265 |
| Routes of administration | By mouth (oral tablets) |
Trintellix is a prescription SSRI antidepressant medication that is used for major depressive disorder treatment. It may be prescribed for other mood disorders at a doctor's discretion but it is primarily indicated as a depression treatment medication that helps to improve moods, energy levels, appetite, sleep, and motivation levels for people suffering from depression. Vortioxetine works to prevent the reuptake of serotonin in the brain so that more of the neurotransmitter is present in the brain and this helps the person feel less of the symptoms of depression. Trintellix is like most other antidepressants in that users will be on the medication as part of a long-term course of treatment.
You can buy Trintellix with a prescription, and your best price on it will be when you order medication online from Canada and Canpharm plus taking advantage of a Trintellix coupon if available.
Directions
Standard dosage for this medication is to take 1 tablet daily, with or without food. Trintellix dosage strength will vary based on the individual and this will be indicated in your prescription.
Ingredients
The active ingredient in Trintellix is Vortioxetine.
Cautions
Let your doctor know if you have any history of bipolar / manic-depressive disorder, suicide attempts, seizures, low sodium in the blood, peptic ulcer disease, irregular bleeding problems, or closed-angle glaucoma before starting on Trintellix.
Missing doses may significantly take away from the effectiveness of antidepressant medication. Be sure to take your medication as frequently as indicated in your prescription. If you miss a dose, do not take a make up dose and resume taking your medication at the usual time the next day instead.
Use of diuretics (water pills) may be inadvisable while you are on Trintellix.
Older adults may be more sensitive to Trintellix side effects.
Be aware of medication expiry date and keep out of reach of children.
Interactions
Negative drug interaction risks are possible between Trintellix and other Rx and OTC medications, including clopidogrel, NSAID pain relievers like ibuprofen, blood thinners like warfarin or dabigatran, and MAO inhibitors like isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. The herbal supplement St. John's Wort may also pose an interaction risk.
Let your doctor know of all medications and supplements you are currently taking before getting a prescription and going to buy Trintellix online.
Side Effects
Trintellix side effects may occur, and some users may experience nausea, constipation, vomiting, or dizziness. If Trintellix side effects are seen you may want to stop use and speak to your doctor again regarding antidepressant medication alternatives for treating major depressive disorder.
Frequently Asked Questions about Trintellix (Vortioxetine)
What is Trintellix used for?
Trintellix (vortioxetine) is a prescription antidepressant used to treat major depressive disorder (MDD) in adults. It helps improve mood, energy levels, and overall functioning by balancing certain chemicals in the brain, particularly serotonin.
How does Trintellix work?
Trintellix works as a serotonin modulator and stimulator. It increases serotonin activity by inhibiting its reuptake and also interacts with multiple serotonin receptors, which may contribute to its antidepressant effects and help reduce common side effects like sexual dysfunction.
How should Trintellix be taken?
Trintellix is taken once daily, with or without food. It’s typically started at a low dose, such as 5 mg or 10 mg, and may be adjusted up to a maximum of 20 mg per day based on response and tolerability. It should be taken consistently at the same time each day.
What are the common side effects of Trintellix?
Common side effects of Trintellix include nausea, constipation, dizziness, and dry mouth. These symptoms often improve with continued use. Sexual side effects are less frequent compared to other antidepressants, but they can still occur.
How long does Trintellix take to work?
Some people may notice mild improvements in sleep, energy, or appetite within 1 to 2 weeks, but full benefits for mood and emotional symptoms may take 4 to 6 weeks or longer. Consistent daily use is important for effectiveness.
Can Trintellix cause withdrawal symptoms?
Yes, stopping Trintellix suddenly may lead to withdrawal symptoms such as mood changes, irritability, dizziness, and sensory disturbances. It’s recommended to taper the dose gradually under medical supervision rather than stopping abruptly.
Is Trintellix addictive?
Trintellix is not considered addictive and does not cause cravings or compulsive use. However, it should only be used as prescribed, and any changes in dosing or discontinuation should be done with guidance from a healthcare provider.
Can Trintellix be taken with other medications?
Trintellix may interact with other medications, especially other antidepressants, blood thinners, NSAIDs, or drugs that affect serotonin. Combining it with other serotonergic drugs can increase the risk of serotonin syndrome, a rare but serious condition.
Who should not take Trintellix?
People who are allergic to vortioxetine or any ingredients in Trintellix should not take it. Caution is advised in those with a history of seizures, bipolar disorder, or recent use of MAO inhibitors, which require a safe washout period before starting Trintellix.
Is Trintellix safe during pregnancy or breastfeeding?
The safety of Trintellix during pregnancy and breastfeeding is not fully established. It should be used only if the potential benefits outweigh the risks. Pregnant or nursing individuals should consult their healthcare provider before starting or continuing the medication.
