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Vagifem (Estradiol)

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Vagifem 10 mcg is a prescription medication consisting of estradiol, an estrogen hormone, in the form of vaginal inserts. It is prescribed for postmenopausal women to address moderate to severe menopausal symptoms affecting the vaginal area.

Fact Table
Formula C18H24O2
License US FDA
Bioavailability Oral: less than 5%
Legal status Rx-Only
Chemical Name Estradiol
Elimination half-life Oral: 13–20 hours, Sublingual: 8–18 hours, Topical (gel): 36.5 hours
Dosage (Strength) 10mcg (18 tablets), 10mcg (36 tablets)
Pregnancy Consult Doctor
Brands Vagifem
Protein binding 98%
PubChem CID 5757
MedlinePlus a601121
ChEBI 16469
ATC code G03CA03
DrugBank DB00783
KEGG D00105
Routes of administration Inserted

Buy Vagifem (Estradiol) online from online Canadian Pharmacy |


Follow your doctor's instructions for using this medication. Typically, it is used once daily for the first 2 weeks and then twice a week afterward.

The applicator comes with a tablet inside.

If the tablet falls out before use, discard it, and use a new applicator and tablet.

Follow the given instructions to insert the applicator into the vaginal area, then push down on the plunger to release the prescribed medication.

Dispose of the applicator after use.


The active ingredient in Vagifem is Estradiol.


Inform your doctor if you are allergic to estradiol.

Before you buy Vagifem, disclose your medical history to your doctor.

Avoid smoking or using tobacco while taking this medication.

This medication may cause dark, blotchy areas on the face and skin known as melasma. Sun exposure can worsen this effect. To minimize your sun exposure, refrain from spending excessive time under the sun.

Do not use this medication during pregnancy.

If you intend to breastfeed, it is advisable to seek guidance from your doctor.


Inform your doctor about all the medications you are currently taking, as certain products such as aromatase inhibitors, fulvestrant, raloxifene, tamoxifen, or toremifene may interact with Vagifem.

Side Effects

Some of the typical adverse effects of Vagifem tablet include headaches, breast discomfort, abnormal vaginal bleeding or spotting, stomach or abdominal cramps, bloating, feelings of nausea and vomiting, hair loss, fluid retention, and vaginal yeast infections.

Frequently Asked Questions about Vagifem

How long does it take for Vagifem to dissolve?

Vagifem is a vaginal tablet that dissolves gradually over time. It can take several hours, sometimes over 24 hours for the tablet to fully dissolve inside the vagina.

Is Vagifem safe for long-term use?

Vagifem is considered safe for long-term use when prescribed and used as directed by a doctor. It is important to discuss your specific situation with your doctor to determine the appropriate duration of treatment and to monitor for any potential risks or side effects associated with long-term use.

Should I take Vagifem in the morning or at night?

Vagifem can be taken at any time of the day that is convenient for you. There is no specific requirement for taking it in the morning or at night. You can choose a time that fits well with your daily routine and allows you to consistently take the medication as prescribed.

Can you use Vagifem once a week?

Vagifem is typically used once daily for the first 2 weeks and then twice a week afterward. It is designed to provide sustained relief from vaginal symptoms associated with menopause.

Can Vagifem cause bleeding?

Yes, Vagifem may cause vaginal bleeding or spotting, especially during the initial stages of treatment. This is a common side effect and usually resolves on its own with continued use.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.