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Description
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Fact Table
| Fact Table | |
|---|---|
| Formula | C18H24O2 |
| License | US FDA |
| Bioavailability | Oral: less than 5% |
| Legal status | Rx-Only |
| Chemical Name | Estradiol |
| Elimination half-life | Oral: 13–20 hours, Sublingual: 8–18 hours, Topical (gel): 36.5 hours |
| Dosage (Strength) | 10mcg (18 tablets), 10mcg (36 tablets) |
| Pregnancy | Consult Doctor |
| Brands | Vagifem |
| Protein binding | 98% |
| PubChem CID | 5757 |
| MedlinePlus | a601121 |
| ChEBI | 16469 |
| ATC code | G03CA03 |
| DrugBank | DB00783 |
| KEGG | D00105 |
| Routes of administration | Inserted |
Vagifem 10 mcg is a prescription medication consisting of estradiol, an estrogen hormone, in the form of vaginal inserts. It is prescribed for postmenopausal women to address moderate to severe menopausal symptoms affecting the vaginal area.
Directions
Follow your doctor's instructions for using this medication. Typically, it is used once daily for the first 2 weeks and then twice a week afterward.
The applicator comes with a tablet inside.
If the tablet falls out before use, discard it, and use a new applicator and tablet.
Follow the given instructions to insert the applicator into the vaginal area, then push down on the plunger to release the prescribed medication.
Dispose of the applicator after use.
Ingredients
The active ingredient in Vagifem is Estradiol.
Cautions
Inform your doctor if you are allergic to estradiol.
Before you buy Vagifem, disclose your medical history to your doctor.
Avoid smoking or using tobacco while taking this medication.
This medication may cause dark, blotchy areas on the face and skin known as melasma. Sun exposure can worsen this effect. To minimize your sun exposure, refrain from spending excessive time under the sun.
Do not use this medication during pregnancy.
If you intend to breastfeed, it is advisable to seek guidance from your doctor.
Interactions
Inform your doctor about all the medications you are currently taking, as certain products such as aromatase inhibitors, fulvestrant, raloxifene, tamoxifen, or toremifene may interact with Vagifem.
Side Effects
Some of the typical adverse effects of Vagifem tablet include headaches, breast discomfort, abnormal vaginal bleeding or spotting, stomach or abdominal cramps, bloating, feelings of nausea and vomiting, hair loss, fluid retention, and vaginal yeast infections.
Frequently Asked Questions about Vagifem
How long does it take for Vagifem to dissolve?
Vagifem is a vaginal tablet that dissolves gradually over time. It can take several hours, sometimes over 24 hours for the tablet to fully dissolve inside the vagina.
Is Vagifem safe for long-term use?
Vagifem is considered safe for long-term use when prescribed and used as directed by a doctor. It is important to discuss your specific situation with your doctor to determine the appropriate duration of treatment and to monitor for any potential risks or side effects associated with long-term use.
Should I take Vagifem in the morning or at night?
Vagifem can be taken at any time of the day that is convenient for you. There is no specific requirement for taking it in the morning or at night. You can choose a time that fits well with your daily routine and allows you to consistently take the medication as prescribed.
Can you use Vagifem once a week?
Vagifem is typically used once daily for the first 2 weeks and then twice a week afterward. It is designed to provide sustained relief from vaginal symptoms associated with menopause.
Can Vagifem cause bleeding?
Yes, Vagifem may cause vaginal bleeding or spotting, especially during the initial stages of treatment. This is a common side effect and usually resolves on its own with continued use.
