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Xadago (Safinamide)

Also Known as Onstryv

Prescription requiredOnly Available By Prescription
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What is Generic?

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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XADAGO is a prescription medicine known as a monoamine oxidase type B (MAO-B) inhibitor. XADAGO is used with levodopa/carbidopa to treat adults with Parkinson's disease (PD) who are having off episodes.

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Tell your physician if you are taking, or planning to take, any prescription or over-the-counter drugs. •Do not take XADAGO if you are taking other monoamine oxidase inhibitors (MAOIs), as it could cause a sudden severe increase in your blood pressure. •The combination of MAO-B inhibitors such as XADAGO and antidepressants has resulted in a serious and sometimes fatal condition called serotonin syndrome. •Do not take XADAGO with opioid medications including meperidine, tramadol, methadone, or propoxyphene, as this could result in serious, sometimes fatal, reactions. •Also, do not take XADAGO with amphetamine, cyclobenzaprine, methylphenidate, or St. John's wort. Taking these drugs together can also result in serotonin syndrome, which could be fatal. •Do not use XADAGO with dextromethorphan, as this has been reported to cause episodes of psychosis or abnormal behavior. Do not use XADAGO if you have hypersensitivity to safinamide, as thiscan cause swelling of the tongue and mouth and trouble breathing. You should not take XADAGO if you have severe liver disease. Do not exceed a dose of50 mg per day of XADAGO if you have moderate liver disease. During treatment with XADAGO you may experience increases in blood pressure.Inform your physician if you have a history of high blood pressure. Possible symptoms of an unsafe rise in blood pressure include severe headache,blurred vision, confusion, seizures, shortness of breath, severe anxiety, and nausea and vomiting. Contact your doctor or seek immediatemedical attention if you experience any of these symptoms. Some patients treated with XADAGO experienced drowsiness or sudden onset of sleep.Do not drive, operate heavy machinery, work in high places or do other dangerous activities until you know how XADAGO affects you. Restriction of foods and beverages containing tyramine is usually not required when treated with the recommended doses of XADAGO. However,it is recommended that you avoid foods containing high amounts of tyramine, such as aged cheeses, as some patients may have an increasedsensitivity that could lead to an unsafe rise in blood pressure. All PD patients should be monitored for hallucinations, impulse control and confusion. The most common side effects seen with XADAGO are uncontrolled movements (dyskinesia), falls, nausea, and insomnia. It is not known if XADAGO is safe and effective in children