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Zepzelca (Lurbinectedin)

Prescription requiredOnly Available By Prescription
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Zepzelca (Lurbinectedin) is a breakthrough therapy for patients with metastatic Small Cell Lung Cancer (SCLC) that has progressed after platinum-based chemotherapy. This innovative oncology medication works by inhibiting the transcription process in cancer cells, which disrupts their ability to proliferate. Zepzelca offers hope to those facing limited treatment options, providing a targeted approach to manage aggressive cancer effectively. Each pack contains a sterile solution for infusion, meticulously prepared to ensure safety and efficacy in cancer care.

Before you buy Zepzelca, it is crucial that you talk to your healthcare provider about potential side effects and Zepzelca Cost.

Fact Table
Formula C41H44N4O10S
License US DailyMed
Bioavailability lower than 5%
Legal status Prescription drug
Chemical Name Lurbinectedin
Elimination half-life 51 hours
Dosage (Strength) 4mg/single-dose vial
Pregnancy Consult a doctor
Brands Zepzelca
Protein binding More than 95%
PubChem CID 57327016
MedlinePlus a618038
ChEBI Not Assigned
ATC code L01XX69
DrugBank 12674
KEGG D11644
Routes of administration Intravenous

Buy Zepzelca (Lurbinectedin) online from online Canadian Pharmacy |


Zepzelca is administered intravenously by a healthcare professional experienced in cancer treatments. The recommended dose is based on body surface area, typically given once every three weeks. Before infusion, Zepzelca must be diluted in a specific volume of 0.9% sodium chloride solution. It is essential to follow the healthcare provider's instructions regarding preparation and administration precisely to ensure optimal outcomes.


  • Calculate the Zepzelca dosing based on body surface area.
  • Use aseptic technique to prepare the diluted solution.
  • Inspect the solution for particulate matter and discoloration before administration.


  • Administer as an intravenous infusion over 60 minutes.
  • Avoid extravasation.
  • Follow with post-infusion monitoring for adverse reactions.


Each vial of Zepzelca contains 4 mg of lurbinectedin as a lyophilized powder.


Zepzelca should be used with caution in patients with pre-existing liver or kidney impairment, as it may require dose adjustments.

It is not recommended for pregnant or breastfeeding women due to potential harm to the fetus or infant.

Patients should be monitored for hematologic toxicity; dose modifications may be necessary in cases of neutropenia or thrombocytopenia.

Avoid use in combination with live vaccines.


Zepzelca can interact with other medications, potentially affecting its efficacy or increasing the risk of adverse effects. It is crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking. Specifically, avoid the use of strong CYP3A4 inhibitors or inducers, as they can alter Lurbinectedin's plasma concentration.

Side Effects

Like all medications, Zepzelca can cause side effects, although not everyone experiences them. Common side effects include:

  • Fatigue
  • Nausea
  • Decreased appetite
  • Diarrhea
  • Neutropenia (low levels of white blood cells)
  • Anemia (low red blood cell counts)
  • Thrombocytopenia (low platelet counts)

Severe side effects may include liver toxicity and pneumonitis. Report any unusual symptoms or side effects to your healthcare provider immediately.

Frequently Asked Questions about Zepzelca (Lurbinectedin)

What is Zepzelca (Lurbinectedin)?

Zepzelca is a prescription medicine used to treat adults with a kind of lung cancer called small cell lung cancer (SCLC).

Who is Zepzelca suitable for?

Zepzelca may be used when your lung cancer has spread to other parts of the body (metastatic), and you have received treatment with chemotherapy that contains platinum, and it did not work or is no longer working.

How does Zepzelca work?

Zepzelca works by inhibiting the growth of cancer cells.

What are the common side effects of Zepzelca?

Common side effects include myelosuppression, hepatotoxicity, and tissue necrosis due to extravasation.

When did the FDA approve Zepzelca?

The FDA's approval date for Zepzelca can be found on the FDA's official website.

What is the dosage of Zepzelca?

The dosage of Zepzelca can be found in the official prescribing information.

How is Zepzelca administered?

Zepzelca is administered as an intravenous infusion.

What precautions should be taken before administering Zepzelca?

Patients should be monitored for signs of myelosuppression, hepatotoxicity, and tissue necrosis due to extravasation.

What should be done in case of suspected adverse reactions?

In case of suspected adverse reactions, contact the healthcare provider immediately.

Are there any support groups for people with small cell lung cancer (SCLC)?

There are several helpful resources and support groups for people with lung cancer.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.