Aduhelm (Aducanumab)

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Fact Table

Fact Table
Generic Name Aducanumab
Brand Name Aduhelm
License FDA approved
Legal Status Prescription Drug
Drug Class Monoclonal antibody (anti-amyloid)
Indication Alzheimer's disease
Dosage Form Intravenous infusion
Dosage (Strength) 170 mg/1.7 mL or 300 mg/3 mL solution
Routes of Administration Intravenous
Pregnancy Not recommended unless clearly necessary
PubChem CID 167333703
ATC Code N06DX55
DrugBank DB11929
KEGG D11553

Aduhelm (Aducanumab) is a treatment approved by the FDA specifically for patients diagnosed with Alzheimer's disease. This medication is a monoclonal antibody designed to target and reduce amyloid beta plaques, which are believed to play a crucial role in the progressive cognitive decline associated with Alzheimer's disease. By targeting these plaques, Aduhelm aims to slow the progression of the disease, potentially improving the quality of life for patients in the preliminary stages of Alzheimer's.

Before you buy Aduhelm , it is crucial that you talk to your healthcare provider about potential side effects and Aduhelm price.

Directions

Aduhelm is administered as an intravenous infusion over approximately one hour. The recommended dosage starts with a titration phase to minimize the risk of side effects. Treatment typically begins with a lower dose, gradually increasing to the full dosage based on patient tolerance. The infusion solution should be prepared by healthcare professionals following strict aseptic techniques and used immediately once prepared.

Ingredients

Active Ingredient: Aducanumab.

Cautions

Before starting Aduhelm, discuss your full medical history with your healthcare provider, especially if you have:

  • History of stroke or mini stroke (transient ischemic attack)
  • Heart conditions, including heart failure
  • A history of brain hemorrhage
  • Other neurological conditions

Patients undergoing treatment should have periodic brain MRI scans to monitor for amyloid-related imaging abnormalities (ARIA), which are side effects associated with treatments that target amyloid beta. Signs of ARIA include temporary swelling in areas of the brain and small spots of bleeding, particularly in the earlier phases of treatment.

Interactions

To date, specific drug-drug interactions with Aduhelm have not been fully characterized. However, given the nature of its action on the brain, it is crucial to inform your healthcare provider about all medications, supplements, and over-the-counter drugs that you are currently taking. Special caution should be noted when using other medications that affect the immune system or cause blood thinning as they may increase the risk of side effects.

Side Effects

The use of Aduhelm Alzheimer's medication can be associated with several side effects, the most significant being amyloid-related imaging abnormalities (ARIA). Other side effects include:

  • Headache
  • Confusion or delirium
  • Dizziness
  • Nausea
  • Hypersensitivity reactions, including rash and hives
  • Fatigue

Patients and caregivers should be vigilant for any new symptoms or worsening of existing conditions and report them to the healthcare provider immediately.

Frequently Asked Questions about Aduhelm (Aducanumab)


What is Aduhelm?

Aduhelm (aducanumab) is a prescription drug used to treat Alzheimer’s disease.


How does Aduhelm work?

Aduhelm works by targeting and reducing amyloid-beta plaques, a key sign of Alzheimer’s disease, in the brain.


How effective is Aduhelm?

Studies have shown that Aduhelm can reduce amyloid-beta plaques in the brain. However, its effectiveness in slowing cognitive decline has been modest and seen only in a subset of patients.


How is Aduhelm administered?

Aduhelm is administered as an intravenous infusion over approximately one hour every four weeks.


How successful is Aduhelm?

Aduhelm has shown some success in slowing the deterioration of cognitive skills in clinical trials, but it does not reverse memory loss.


How safe is Aduhelm?

Aduhelm can cause some serious health issues, including temporary brain swelling or bleeding. However, these usually clear up with time.


How long do you have to take Aduhelm?

Aduhelm is typically taken once a month for the rest of the patient’s life.


Is Aduhelm FDA approved?

Yes, Aduhelm was approved by the FDA under the Accelerated Approval pathway in 2021.