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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Brenzys (Etanercept) is a biologic medication approved for the treatment of several chronic inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. As a tumor necrosis factor (TNF) inhibitor, Brenzys works by blocking the action of TNF, a substance in the body's immune system that causes inflammation and can lead to immune system diseases.
Brenzys is designed to reduce the signs and symptoms of inflammatory conditions, inhibit the progression of structural damage, and improve physical function in adults. It is available in the form of a pre-filled syringe or auto-injector pen, making administration convenient for self-use at home. Before you buy Brenzys, it is crucial that you talk to your healthcare provider about potential side effects and Brenzys cost.
| Fact Table | |
|---|---|
| Formula | C2224H3475N621O698S36 |
| License | FDA approved |
| Bioavailability | 58% (subcutaneous) |
| Legal status | Prescription Drugs |
| Chemical Name | Etanercept |
| Elimination half-life | Approximately 70 hours |
| Dosage (Strength) | 50 mg (per weekly injection) |
| Pregnancy | Category B (may cross the placenta) |
| Brands | Brenzys, Enbrel |
| Protein binding | Not applicable |
| PubChem CID | 123879 |
| MedlinePlus | a602008 |
| ChEBI | 50143 |
| ATC code | L04AB01 |
| DrugBank | DB00005 |
| KEGG | D00742 |
| Routes of administration | Subcutaneous |
Brenzys is administered by subcutaneous injection.
Typical dosage involves a once-weekly injection, although the specific regimen may vary depending on the condition being treated and the patient's response to therapy.
It is crucial to rotate injection sites (abdomen, thighs, upper arms) to prevent skin irritation.
The active ingredient in Brenzys is etanercept.
Patients with known allergies to etanercept or any other components of Brenzys should not use this medication.
As Brenzys can weaken the immune system, there is an increased risk of serious infections. Patients should inform their doctor of any signs of infection, including fever, fatigue, or flu-like symptoms.
Patients with a history of heart failure, demyelinating diseases, or hematologic disorders should use Brenzys with caution.
Live vaccines should be avoided during treatment with Brenzys. Consult your healthcare provider before receiving any vaccines.
Brenzys auto injector can interact with other medications, which can alter how Brenzys or the other medications work or increase the risk of serious side effects. It is essential to inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter products, and herbal supplements. Particularly, the use of other immunosuppressive agents or TNF blockers concurrently with Brenzys should be approached with caution.
While Brenzys helps many patients, it can also cause side effects. The most common side effects include:
What is the drug Brenzys used for?
Brenzys (etanercept) is used to treat autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. It works by reducing inflammation and modifying the immune system's activity.
What does Enbrel do to your body?
Enbrel (etanercept) is a tumor necrosis factor (TNF) blocker that helps to reduce inflammation and halt the progression of autoimmune diseases. It works by inhibiting the activity of TNF, a substance in the body that causes inflammation in the joints and other tissues.
How long does Brenzys take to work?
Brenzys may start to show effects within 2 to 12 weeks of starting treatment, although the time can vary depending on the individual and the condition being treated.
What are the major side effects of etanercept?
The major side effects of etanercept can include:
Severe but less common side effects include serious infections, blood disorders, nervous system disorders, and heart failure.
Where to inject Brenzys?
Brenzys is typically injected subcutaneously (under the skin). Common injection sites include the front of the thighs, the abdomen (avoiding the 2-inch area around the navel), and the outer area of the upper arms.
Is etanercept safe long term?
Etanercept is generally considered safe for long-term use, but it requires regular monitoring by a healthcare provider. Long-term use can increase the risk of serious infections, certain types of cancer, and other immune system-related issues. Regular check-ups and blood tests are essential to monitor for potential side effects.
What is the half-life of Brenzys?
The half-life of Brenzys (etanercept) is approximately 70 hours. This means it takes about 70 hours for the concentration of the drug in the blood to reduce by half.
How long can Brenzys be out of the fridge?
Brenzys can be stored at room temperature (up to 25°C or 77°F) for a maximum of 14 days. If it is not used within this time frame, it should be discarded. Once it has been brought to room temperature, it should not be refrigerated again.
Is Brenzys a biologic?
Yes, Brenzys is a biologic medication. It is a biosimilar to Enbrel (etanercept), meaning it is highly similar to the original biologic drug and has no clinically meaningful differences in terms of safety, purity, and potency.
Where to inject Brenzys?
As mentioned earlier, Brenzys is injected subcutaneously. The preferred injection sites include the front of the thighs, the abdomen (except for the 2-inch area around the navel), and the outer area of the upper arms. It is important to rotate injection sites to avoid irritation.
