Cerdelga (Eliglustat)

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Fact Table

Fact Table
Formula C23H36N2O4
License US DailyMed, EU EMA
Bioavailability lower than 5%
Legal status Prescription drug
Chemical Name Eliglustat
Elimination half-life 6.5 hours - 8.9 h
Dosage (Strength) 84mg
Pregnancy Consult a doctor
Brands Cerdelga
Protein binding 76% to 83%
PubChem CID 23652731
MedlinePlus a618038
ChEBI 82752
ATC code A16AX10
DrugBank DB09039
KEGG D09893
Routes of administration By mouth

Cerdelga is a Gaucher disease Type 1 treatment medication available by prescription and used by adult patients with GD1 who have their 2D6 liver enzyme failing, and that causes lipid buildup in the body. Eliglustat is a glucosylceramide synthase inhibitor drug used as part of substrate reduction therapy. Hence, patients benefit from reduced GL-1 peptide production and see improved liver, spleen, and bone conditions over time. Buy Cerdelga from Canada and Canpharm and get the lowest Cerdelga cost.

Directions

The standard dosage is Cerdelga 84mg, taken 1 or 2 times daily based on the patient's genotype test results. Dosage may vary; you should always take your medication precisely as indicated in your prescription.

Medication can be taken with or without food, and you should take Cerdelga simultaneously daily. Swallow capsules whole with water.

Ingredients

The active ingredient is Cerdelga is Eliglustat.

Cautions

Let your doctor know of any history of liver or kidney disease, cardiac failure, heart blockages, bradycardia, ventricular arrhythmia, long QT syndrome, or ongoing use of class IA or class III antiarrhythmics before starting on Cerdelga.

Avoid eating grapefruit or drinking grapefruit juice while using this medication.

Women who are pregnant or breastfeeding should not use Cerdelga unless their doctor approves it.

For use with ages 18 and up only.

Be aware of the medication expiry date.

Interactions

Adverse drug interactions may occur between Cerdelga and other Rx medications, including laronidase, tipranavir, bevacizumab, blinatumomab, vandetanib, ivabradine, indinavir, vedolizumab, imatinib, emicizumab, raltegravir, ivacaftor, losartan, nintedanib, ethchlorvynol, dabigatran, cysteamine, denosumab, dornase alfa, infliximab, lenalidomide, eculizumab, regorafenib, sacrosidase, atezolizumab, abacavir, lamivudine, and zidovudine.

Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Cerdelga online.

Side Effects

Side effects from using Cerdelga may occur, and some users may experience nausea, diarrhea, back pain, headache, fatigue, dizziness, or constipation. If side effects are experienced, it may be best to stop use and meet with a doctor again to discuss Gaucher disease treatment medication alternatives.

Frequently Asked Questions about Cerdelga (Eliglustat)


What is Cerdelga (Eliglustat)?

Cerdelga is the only first-line oral therapy indicated for the long-term treatment of most adults with Gaucher disease type 1 (GD1).


Who can use Cerdelga?

Cerdelga is used for adults with Gaucher disease type 1 who are CYP2D6 extensive metabolizers (EMs), intermediate metabolizers (IMs), or poor metabolizers (PMs) as detected by an FDA-cleared test.


Who should not use Cerdelga?

Certain patients should not use Cerdelga based on their CYP2D6 metabolizer status due to an increased risk of side effects, including heart problems.


How is Cerdelga administered?

Cerdelga is an oral therapy, meaning it is taken by mouth.


What are the limitations of Cerdelga use?

CYP2D6 ultra-rapid metabolizers may not achieve adequate concentrations of Cerdelga to achieve a therapeutic effect.


What tests are required before starting Cerdelga?

Your doctor will perform a test to make sure that Cerdelga is right for you.


Can Cerdelga interact with other medicines?

Cerdelga can affect the way other medicines work and other medicines can affect how Cerdelga works.


What are the potential side effects of Cerdelga?

Using Cerdelga with other medicines or herbal supplements may cause an increased risk of side effects, including changes in electrical activity of your heart (ECG changes) and irregular heart beat (arrhythmias).


Where can I find more information about Cerdelga?

More information about Cerdelga can be found on the official Cerdelga patient site.