Cibinqo (Abrocitinib)
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Fact Table
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|---|---|
| Formula | C18H19F4N5O2 |
| License | FDA approved |
| Bioavailability | Approximately 60% |
| Legal status | Prescription Drug |
| Chemical Name | Abrocitinib |
| Elimination half-life | About 5 hours |
| Dosage (Strength) | 50 mg, 100 mg, or 200 mg oral tablets |
| Pregnancy | Not recommended during pregnancy |
| Brands | Cibinqo |
| Protein binding | About 64% |
| PubChem CID | 116906691 |
| MedlinePlus | Not specifically listed |
| ChEBI | 145388 |
| ATC code | L04AA49 |
| DrugBank | DB15660 |
| KEGG | D11441 |
| Routes of administration | Oral |
Cibinqo (abrocitinib) is an innovative oral medication designed for the treatment of moderate to severe atopic dermatitis in adults and adolescents who are candidates for systemic therapy. As a Janus kinase (JAK) inhibitor, Cibinqo works by modulating the signaling pathway that affects inflammation and immune function, thereby reducing the symptoms of atopic dermatitis such as itching and inflammation.
Cibinqo is available in the form of tablets and comes in various strengths to suit individual patient needs and dosing requirements. Before you buy Cibinqo, it is crucial that you talk to your healthcare provider about potential side effects and Cibinqo cost.
Directions
Cibinqo should be taken once daily with or without food, and it is crucial to follow your healthcare provider's instructions regarding the dosage. The recommended starting dose is typically based on the patient's weight and severity of the disease:
Adults and Adolescents (12 years and older): Typically, the treatment begins with a dose of 100 mg taken orally once per day, which may be adjusted based on therapeutic response and side effects.
Continue to take Cibinqo as directed by your healthcare provider. Do not adjust the dose or discontinue the medication without consulting your doctor.
Ingredients
Active Ingredient: Abrocitinib
Cautions
Patients with severe hepatic impairment, those with a history of serious hypersensitivity to abrocitinib, or individuals who are taking other JAK inhibitors should avoid using Cibinqo.
It is important to discuss your complete medical history with your healthcare provider, including any past or present infections, liver, or kidney disease, or if you are pregnant or plan to become pregnant.
Interactions
Cibinqo can interact with other medications, which can alter how Cibinqo or the other medications work. Be sure to inform your healthcare provider about all the medications you are taking, including blood thinners (anticoagulants), other JAK inhibitors, strong CYP3A4 inhibitors (e.g., ketoconazole), strong CYP3A4 inducers (e.g., rifampicin). Avoid taking Cibinqo with these medications unless specifically directed by your healthcare provider.
Side Effects
Common side effects of Cibinqo for eczema include nausea, headache, mild rashes, and elevated blood pressure.
Frequently Asked Questions about Cibinqo (Abrocitinib)
What is Cibinqo ?
Cibinqo, also known as abrocitinib, is a Janus Kinase (JAK) inhibitor used to treat certain skin conditions.
What is Cibinqo used for?
Cibinqo is used to treat moderate-to-severe atopic dermatitis (eczema) in adults and children over 12 years of age who have not found relief with other treatments.
How does Cibinqo work?
Cibinqo works by selectively blocking JAK1, an enzyme associated with inflammation and itch in atopic dermatitis.
Does Cibinqo cause weight gain?
Weight gain is not specifically listed as a side effect of Cibinqo.
Is Cibinqo a biologic?
No, Cibinqo is not a biologic. It is a type of medicine known as a Janus Kinase (JAK) inhibitor.
What does Cibinqo treat?
Cibinqo is used to treat moderate-to-severe atopic dermatitis (eczema) in adults and children over 12 years of age.
Why is Cibinqo so expensive?
The cost of Cibinqo can vary based on several factors such as your treatment plan and your insurance coverage. In general, biologic drugs cost more than biosimilar drugs.
What are the benefits of Cibinqo?
Cibinqo has been shown to be effective in clearing skin, improving itch, and managing the extent and severity of eczema.
How long does it take for Cibinqo to work?
In clinical studies, significant improvement in skin symptoms was observed in patients after 3 months of treatment with Cibinqo.
What not to take with Cibinqo?
Cibinqo is not recommended for use in combination with other JAK inhibitors, biologic immunomodulators, or with other immunosuppressants.
