Combigan (Brimonidine / Timolol)

Prescription Required
Brand
Dose Size & Price Qty
0.2%-0.5% 5ml
Generic
Dose Size & Price Qty
0.2%/0.5% 5ml
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Fact Table

Fact Table
Formula Brimonidine: C11H10BrN5
Timolol: C13H24N4O3S
License FDA approved
Bioavailability Minimal systemic absorption (ocular use)
Legal status Prescription Drug
Chemical Name Brimonidine: 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
Timolol: (S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
Elimination half-life Brimonidine: ~2 hours
Timolol: ~4–6 hours
Dosage (Strength) Brimonidine 0.2% / Timolol 0.5% ophthalmic solution
Pregnancy Use with caution; consult doctor
Brands Combigan
Protein binding Brimonidine: ~29%
Timolol: ~60%
PubChem CID Brimonidine: 60953
Timolol: 33624
MedlinePlus a607065
ChEBI Brimonidine: 3176
Timolol: 9555
ATC code S01ED51
DrugBank Brimonidine: DB00484
Timolol: DB00373
KEGG Brimonidine: D00692
Timolol: D08697
Routes of administration Ophthalmic (eye drops)

Combigan is an ocular hypertension treatment medication prescribed for people with glaucoma or other conditions where there is excessive fluid pressure on the optic nerve of the eye. Brimonidine is an alpha-2 adrenergic agonist drug that reduces the amount of fluid in the eye and Timolol is a beta-blocker that limits increases in intraocular pressure by reducing aqueous humor in the eyeball. You can buy Combigan eye drops with a prescription here at Canpharm.

Directions

Standard dosage guidelines for Combigan eye drops is to place 1 drop into affected eyeballs 2x daily, with doses spaced 12 hours apart

Ingredients

The active ingredients in Combigan are Brimonidine and Timolol

Cautions

Let your doctor know of any history of COPD, asthma, heart failure, slow heartbeat, stroke, blood clots, high or low blood pressure, Raynaud's syndrome, diabetes, thyroid disorder, myasthenia gravis, or depression before starting on Combigan eye drops

Not for use with children under the age of 2

Do not use medication remaining in Combigan generic eye dropper if it is longer than 28 days after opening it due to the risk of bacteria forming and being transferred into the eye

Women who are pregnant or breastfeeding should only use this medication if a doctor approves it

Interactions

Negative drug interactions may occur between Combigan and other Rx or OTC medications, including amlodipine, furosemide, gabapentin, hydrochlorothiazide, lisinopril, losartan, metoprolol, rosuvastatin, simvastatin, tamsulosin, and tramadol. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Combigan eye drops online.

Side Effects

Combigan drops side effects may occur, and some users may experience slowed or accelerated heart rate, shallow breathing, eye swelling or redness, eye pain, eye watering or numbness or a tingling feeling in hands or feet. If side effects are seen it may be best to discontinue use and meet with a doctor to discuss open-angle glaucoma treatment medication alternatives.

Frequently Asked Questions about Combigan


What is Combigan?

Combigan is a prescription eye drop that contains brimonidine (alpha agonist) and timolol (beta-blocker). It is used to lower eye pressure in patients with glaucoma or ocular hypertension.


What is Combigan used for?

Combigan is primarily used to reduce intraocular pressure (IOP) in people with open-angle glaucoma or ocular hypertension to help prevent vision loss.


How long can you use Combigan eye drops?

Combigan is safe for long-term use under a doctor’s supervision. Regular eye pressure check-ups are needed to monitor effectiveness and potential side effects.


Do Combigan eye drops need to be refrigerated?

No, Combigan does not require refrigeration. It should be stored at room temperature (59-77°F or 15-25°C) in a dry place, away from light.


How does Combigan work?

Combigan works by:

  • Brimonidine (Alpha Agonist) – Reduces fluid production and increases fluid drainage in the eye.
  • Timolol (Beta-Blocker) – Lowers eye pressure by decreasing fluid production.

Together, these help reduce intraocular pressure (IOP) and prevent optic nerve damage.


How long does Combigan stay in your system?

  • Brimonidine: Has a half-life of ~2–3 hours, so it is mostly cleared within a day.
  • Timolol: Has a half-life of ~4–6 hours, but systemic effects can last up to 24 hours.

How long does it take for Combigan to work?

Combigan starts lowering eye pressure within 1–2 hours after application, with peak effects around 2–6 hours.


How to use Combigan eye drops?

  1. Wash hands before use.
  2. Tilt head back and pull down the lower eyelid.
  3. Squeeze one drop into the affected eye(s).
  4. Close your eyes for 1–2 minutes (do not blink).
  5. Press on the inner corner of your eye for 1 minute to reduce systemic absorption.
  6. Wait at least 5–10 minutes before using other eye drops.

Is Combigan a beta-blocker?

Yes, Combigan contains timolol, which is a beta-blocker that reduces fluid production in the eye to lower pressure.


Is Combigan a steroid?

No, Combigan is not a steroid. It contains an alpha agonist (brimonidine) and a beta-blocker (timolol) to reduce intraocular pressure.

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