| Fact Table | |
|---|---|
| Formula | C24H33FO6 |
| License | FDA approved |
| Bioavailability | Not well defined; systemic absorption depends on skin integrity, occlusion, and duration of use |
| Legal status | Prescription only (Rx) |
| Chemical Name | 6a,9a-difluoro-11ß,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-acetate |
| Elimination half-life | Not specifically established for topical use |
| Dosage (Strength) | 4 micrograms/cm² medicated tape applied once daily (may be changed every 12–24 hours) |
| Pregnancy | Category C – Use only if potential benefit justifies potential risk |
| Brands | Cordran Tape |
| Protein binding | High (typical of corticosteroids; exact percentage not defined) |
| PubChem CID | 5284604 |
| MedlinePlus | a601124 |
| ChEBI | 50719 |
| ATC code | D07AB06 |
| DrugBank | DB00591 |
| KEGG | D01327 |
| Routes of administration | Topical (medicated tape applied to skin) |
Cordran Tape is a transparent plastic surgical tape that contains flurandrenolide, a corticosteroid for topical use. Flurandrenolide works by decreasing inflammation and reducing swelling, redness, and itching in the skin. It's used to manage irritation and itching from certain skin problems, especially those that are dry, scaly, and limited to small, specific areas.
Apply Cordran Tape to clean, dry skin over the affected area. Before applying it, cut the tape to fit the lesion with small scissors. The skin should be clean and dry to ensure the tape sticks properly.
Remove the tape from the package and press it firmly onto the lesion. Smooth down the edges to make sure it adheres well. If the ends of the tape loosen, they can be trimmed off and replaced with fresh tape.
The usual application schedule is to replace the tape every 12 hours for the first 1-2 applications. After that, many patients can leave the tape on for 24 hours at a time.
Some people may keep it on even longer if the tape sticks well and the condition improves. The tape can stay in place during bathing or showering. Pat it dry afterward if it gets wet. Don't pull the tape off roughly, as this may irritate the skin.
The active ingredient in this drug is flurandrenolide.
Avoid taking or using this medication if any of the following apply:
Common side effects of Cordran include:
These skin-related effects are generally mild and tend to stay at the application site. Some people may also notice increased hair growth or redness in treated areas. Let your healthcare provider know if irritation persists or worsens.
More serious reactions are uncommon but can occur, especially when Cordran is used under occlusive dressings. These may include skin thinning, stretch marks, secondary infections, or significant softening and breakdown of the skin. In rare cases, heat rash or allergic contact dermatitis may develop. Stop using the medication and contact your provider if you notice worsening redness, signs of infection, or significant changes in the texture of your skin.
What is Cordran (Flurandrenolide) used for?
Cordran is a topical corticosteroid used to relieve inflammation and itching associated with skin conditions such as eczema, dermatitis, allergies, and rashes. It works by suppressing the immune response that causes inflammation.
How does Flurandrenolide work on the skin?
Flurandrenolide works by reducing the activity of inflammatory chemicals in the skin, such as prostaglandins and leukotrienes. This helps decrease swelling, redness, and itching in affected areas.
What forms does Cordran come in?
Cordran is available in several topical formulations, including ointment, cream, lotion, and a unique tape form (Cordran Tape), which provides continuous delivery of the medication to a specific area.
How should Cordran be applied?
Cordran should be applied in a thin layer to the affected skin area, usually 1 to 3 times daily as directed by a healthcare provider. It should not be used on large body areas or under occlusive dressings unless directed by a doctor.
What are the common side effects of Cordran?
Common side effects may include burning, itching, dryness, irritation, or redness at the application site. These effects are usually mild and temporary. If symptoms worsen, medical attention may be needed.
Can Cordran be used on the face or groin?
Cordran should be used with caution on sensitive areas like the face, groin, or underarms due to the higher risk of thinning skin and other side effects. These areas are more prone to absorbing the steroid.
Is Cordran safe for long-term use?
Long-term use of topical corticosteroids like Cordran can lead to skin thinning, stretch marks, and hormone suppression. It should only be used for extended periods under strict medical supervision.
Can children use Cordran?
Cordran can be used in children, but with caution. Because children's skin absorbs corticosteroids more easily, there is a greater risk of systemic side effects. Pediatric use should be closely monitored by a healthcare provider.
What should be avoided while using Cordran?
Avoid applying Cordran to open wounds, eyes, or mucous membranes. Do not bandage or tightly cover the treated area unless directed. Also, avoid using other topical products on the same site unless approved.
What should I do if I miss a dose of Cordran?
If a dose is missed, apply it as soon as remembered. If it’s almost time for the next dose, skip the missed one. Do not double up or apply extra medication to make up for a missed dose.
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (e.g., different shape or color), as trademark laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.