Creon (Pancreatic Enzyme)
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Fact Table
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| Formula | Mixture (lipase, amylase, protease enzymes derived from porcine pancreas) |
| License | FDA approved |
| Bioavailability | Not systemically absorbed; acts locally in the gastrointestinal tract |
| Legal status | Prescription only (Rx) |
| Chemical Name | Pancrelipase (porcine-derived mixture of digestive enzymes) |
| Elimination half-life | Not applicable (enzymes degraded in the GI tract) |
| Dosage (Strength) | Capsules containing lipase 3,000–36,000 units (dose individualized per meal) |
| Pregnancy | Use if clearly needed; minimal systemic exposure |
| Brands | Creon |
| Protein binding | Not applicable |
| PubChem CID | Not applicable (enzyme mixture) |
| MedlinePlus | a604035 |
| ChEBI | 80664 |
| ATC code | A09AA02 |
| DrugBank | DB00085 |
| KEGG | D00204 |
| Routes of administration | By mouth (delayed-release oral capsules) |
Creon is a prescription digestive enzyme medication used for chronic pancreatitis treatment and improving patients' digestive function. It is commonly prescribed for chronic pancreatitis, cystic fibrosis, pancreatic cancer, or following a pancreatectomy or gastrointestinal bypass surgery. The small intestine's ability to break down and digest fats, starch, and proteins in food is improved to promote better nutritional intake and better gut function for people with these conditions.
You can buy Creon medication with a prescription, and your best price on it will be when you order medication online from Canada and Canpharm.
Directions
A patient's Creon dosing will be determined by the doctor based on extent of condition and response to any existing treatment. Only take your medication exactly as indicated in the prescription, do not exceed the dosage or take less of the medication.
Ingredients
The active ingredient in Creon is Pancreatic Enzyme.
Cautions
Let your doctor know if you have any history of acute pancreatitis (sudden/severe swelling of the pancreas), gout, kidney disease, hyperuricemia (high uric acid level in the blood), or intestinal problems like blockages before starting on Creon.
Using Creon may affect blood sugar levels for diabetics. Speak with your doctor about possible changes to your diabetes management program.
Let your doctor know if you have surgery planned anytime in the near future before beginning on Creon.
Only use medication if pregnant or breastfeeding if approved to do so by your doctor.
Interactions
Negative drug interaction risks are possible between Creon and other Rx medications, including Hushart, Acarbose, and Miglitol. Let your doctor know of all medications you are currently taking before getting a prescription and going to buy Creon online.
Side Effects
Creon side effects may occur, and some users may have diarrhea, constipation, headache, abdominal pain/cramps/bloating, gas, cough, nausea, or vomiting. If Creon side effects are seen you may want to stop use and speak with you doctor again regarding pancreatitis medication alternatives.
Frequently Asked Questions about Creon
What is Creon used for?
Creon is a prescription medication used to treat people who cannot digest food properly due to a lack of pancreatic enzymes. This condition is known as exocrine pancreatic insufficiency (EPI), and it commonly occurs in individuals with cystic fibrosis, chronic pancreatitis, pancreatic cancer, or those who have had pancreatic surgery.
How does Creon work?
Creon contains a combination of digestive enzymes—lipase, protease, and amylase—that help break down fats, proteins, and carbohydrates in the food you eat. These enzymes mimic those normally produced by the pancreas and are released in the small intestine to aid digestion.
How should I take Creon?
Creon should be taken with every meal and snack, exactly as prescribed by your doctor. The capsules should be swallowed whole with plenty of fluid and not chewed or crushed, as this can irritate the mouth and reduce effectiveness. For those who can't swallow capsules, they may be opened and the contents mixed with soft acidic food, like applesauce, but should be taken immediately.
What are the common side effects of Creon?
Common side effects of Creon may include stomach pain, gas, bloating, nausea, constipation, or diarrhea. These are generally mild, but if symptoms persist or worsen, it’s important to consult a healthcare provider.
Can Creon be taken long-term?
Yes, Creon is often used as a long-term treatment for people with chronic conditions causing pancreatic enzyme deficiency. It is considered safe for extended use when taken under medical supervision and with routine monitoring.
Is Creon safe for children?
Yes, Creon is commonly prescribed for children, especially those with cystic fibrosis. Dosing is carefully based on the child’s weight, diet, and enzyme needs. It is important to follow the pediatrician’s instructions closely to ensure proper growth and digestion.
What happens if I miss a dose of Creon?
If you miss a dose, take it as soon as you remember, but only with food. If the next meal or snack is soon, skip the missed dose and continue with your regular schedule. Do not double up to make up for a missed dose.
Are there any serious risks or warnings with Creon?
High doses of Creon, especially in children with cystic fibrosis, have been linked to a rare but serious bowel condition called fibrosing colonopathy. Symptoms can include abdominal pain, bloating, nausea, vomiting, or constipation. Always follow your doctor’s dosing recommendations to avoid this risk.
Can Creon interact with other medications?
Creon does not have many known drug interactions, but it’s important to inform your healthcare provider of all medications and supplements you are taking. Taking Creon with antacids or certain iron supplements may affect absorption.
Does Creon need to be refrigerated or stored in a special way?
Creon should be stored at room temperature in a tightly closed container and protected from moisture and heat. It should not be refrigerated or frozen. Always check the packaging for the most up-to-date storage guidelines.
