Daraprim (Pyrimethamine)
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Description
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Fact Table
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| Formula | C12H13ClN4 |
| License | FDA approved |
| Bioavailability | ~90% |
| Legal status | Prescription Drug |
| Chemical Name | 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |
| Elimination half-life | ~96 hours |
| Dosage (Strength) | 25mg tablets |
| Pregnancy | Use with caution; consult doctor (Category C) |
| Brands | Daraprim |
| Protein binding | ~87% |
| PubChem CID | 4993 |
| MedlinePlus | a682231 |
| ChEBI | 8673 |
| ATC code | P01BD01 |
| DrugBank | DB00205 |
| KEGG | D08474 |
| Routes of administration | By mouth |
Daraprim is a toxoplasmosis treatment medication that may also be prescribed to treat malaria or cystoisosporiasis infection. Daraprim uses may also be for people with HIV infection who are more at risk for toxoplasmosis. Pyrimethamine is an aminopyridine derivate parasiticide drug that will effectively eliminate the parasites and prevent the infection from worsening. It will usually be used alongside Leucovorin to minimize side effects for users while still ensuring the parasitic infection is ended. You can buy Daraprim with a prescription here at Canpharm.
Directions
Standard dosage for this medication is to take one tablet 1 or 2x daily. Take your medication exactly as indicated in your prescription.
Ingredients
The active ingredient in Daraprim is Pyrimethamine
Cautions
Let your doctor know of any history of liver or kidney problems, seizures, megaloblastic anemia, low folic acid levels, low red or white blood cell counts, or low blood platelet counts before starting on Daraprim
People with certain surgeries scheduled in the near future may not be candidates to use Daraprim until after their surgery and a possible recovery time
Women who are pregnant or breastfeeding should not use this medication unless their doctor approves it because of the risk of depleted folic acid levels
Use of this medication may slow the removal of other medications from your body
Store at room temperature away from light and moisture and be aware of medication expiry date
Interactions
Negative drug interactions may occur between Daraprim and other Rx or OTC medications, including auronofin, aurothioglucose, deferiprone, glucarpidase, sodium thiomalate, kaolin, magaldrate, methotrexate, pralatrexate, proguanil, sapropterin, sulfadiazine, sulfamethoxazole, sulfasalazine, trimethoprim, trimetrexate, and zidovudine. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Daraprim online.
Side Effects
Daraprim side effects may occur, and some users may experience nausea, vomiting, appetite loss, sore throat, fever, or fatigue. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss parasitic infection treatment medication alternatives and a pharmacist for a lower Daraprim price.
Frequently Asked Questions about Daraprim (Pyrimethamine)
What is Daraprim used for?
Daraprim (pyrimethamine) is used to treat and prevent parasitic infections, such as toxoplasmosis and malaria.
How does Daraprim work?
Daraprim works by inhibiting the activity of the enzyme dihydrofolate reductase, which is necessary for the growth of certain parasites, thus preventing their replication.
How should Daraprim be taken?
Daraprim is typically taken orally with food, as directed by your doctor. The dosage depends on the condition being treated and may vary for different patients.
What are the side effects of Daraprim?
Common side effects include nausea, vomiting, abdominal pain, rash, and fever. Serious side effects can include blood disorders, liver problems, and allergic reactions.
How long does it take for Daraprim to work?
The effectiveness of Daraprim can vary depending on the infection. It may take a few days to weeks to start noticing improvement, and treatment may last several weeks depending on the condition.
Who should not take Daraprim?
Daraprim should not be used by individuals who are allergic to pyrimethamine or any of its components, or those with pre-existing blood disorders like megaloblastic anemia.
Can Daraprim interact with other medications?
Yes, Daraprim can interact with other medications, such as folic acid supplements, certain antiepileptic drugs, and other medications affecting bone marrow function.
Can Daraprim cause low blood cell counts?
Yes, one of the serious side effects of Daraprim is bone marrow suppression, which can lead to low white blood cell or red blood cell counts (anemia, leukopenia, or thrombocytopenia).
How should Daraprim be stored?
Store Daraprim at room temperature, away from moisture, light, and heat, and keep it out of the reach of children.
Can I stop taking Daraprim suddenly?
It is important to complete the full course of Daraprim as prescribed to ensure the infection is fully treated. Stopping the medication prematurely can lead to treatment failure or a relapse of the infection.
