Darzalex (Daratumumab)
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Description
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Fact Table
| Fact Table | |
|---|---|
| Generic Name | Daratumumab |
| License | FDA approved |
| Bioavailability | Not available |
| Legal Status | Prescription Drug |
| Chemical Name | Daratumumab |
| Elimination Half-life | Approximately 18 days |
| Dosage (Strength) | 100 mg/5 mL or 400 mg/20 mL |
| Pregnancy | Contraindicated; should not be used during pregnancy |
| Brands | Darzalex |
| Protein Binding | Not available |
| PubChem CID | Not available |
| MedlinePlus | Not listed specifically for Darzalex |
| ChEBI | Not available |
| ATC Code | L01XC24 |
| DrugBank | DB09331 (Daratumumab) |
| KEGG | D10881 (Daratumumab) |
| Routes of Administration | Intravenous |
Darzalex (daratumumab) is a monoclonal antibody used in the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. As a targeted therapy, Darzalex works by binding to a specific protein called CD38, which is highly expressed on the surface of myeloma cells. By doing so, it helps the immune system detect and destroy these cancer cells.
Darzalex is usually prescribed after other treatments have failed, and it can be used alone or in combination with other medications depending on the specific needs and health status of the patient. It is administered by a healthcare professional through intravenous (IV) infusion. Before you buy Darzalex, it is crucial that you talk to your healthcare provider about potential side effects and Darzalex cost.
Directions
Darzalex is administered in a clinical setting under the supervision of a healthcare provider experienced in the use of cancer chemotherapeutic agents. The dosage and schedule depend on several factors, including the patient's medical condition, body size, and response to treatment.
Typically, Darzalex is given once a week for the first eight weeks, then every two weeks for the next 16 weeks, and thereafter every four weeks. Each session of administration can last several hours due to the need for careful monitoring and the rate of infusion.
Ingredients
Active Ingredient: Daratumumab.
Cautions
Patients should inform their healthcare provider of any history of severe allergic reactions. Emergency medical help should be sought if symptoms of a severe allergic reaction occur, such as difficulty breathing, hives, or swelling of the face, lips, tongue, or throat.
Darzalex can make patients more susceptible to infections. Patients should report any signs of infection to their healthcare provider.
Regular blood tests are necessary to monitor blood cell counts, as Darzalex can affect these levels, potentially leading to conditions like anemia or thrombocytopenia.
Interactions
Darzalex injection may interact with other medications, which can affect how it, or the other medications work or increase the risk of serious side effects. It is crucial to discuss all medications (prescription, non-prescription, and herbal products) with the healthcare provider prior to starting treatment with Darzalex. Patients should also avoid receiving live vaccines during treatment.
Side Effects
Common side effects include:
- Infusion Reactions (cough, shortness of breath, throat irritation, and chills)
- Fatigue and Weakness
- Nausea and Vomiting
- Diarrhea or Constipation
- Fever
Frequently Asked Questions about Darzalex (Daratumumab)
What is Darzalex (Daratumumab)?
Darzalex (daratumumab) is a prescription medication used to treat multiple myeloma, a type of cancer that affects plasma cells. It’s a type of drug known as a monoclonal antibody.
Is Darzalex chemotherapy?
No, Darzalex is not chemotherapy. It’s a type of biologic treatment and is sometimes called targeted therapy or immunotherapy.
How does Darzalex work?
Darzalex works by binding to a specific protein called CD38 on the surface of multiple myeloma cells, causing cell death.
How is Darzalex administered?
Darzalex is administered by infusion directly into a vein by a healthcare professional.
How long does Darzalex stay in your system?
Darzalex typically stays in your body for 3 months or longer after you stop taking it.
What are the most common side effects of Darzalex?
The most commonly reported side effects of Darzalex include nausea, diarrhea or constipation, upper respiratory infections, infusion reactions, and low blood cell counts.
How long do Darzalex side effects last?
Most mild side effects of Darzalex tend to lessen in a few days or a couple of weeks. Some serious side effects can decrease quickly with treatment but others may last a long time.
Does Darzalex cause hair loss?
Hair loss is not commonly reported as a side effect of Darzalex.
What is the success rate of Darzalex?
In a study, 47.6% of patients had a complete response or better when Darzalex was added to their treatment regimen.
What are the benefits of Darzalex?
Darzalex is effective in treating multiple myeloma in several settings. It can be used alone or in combination with other medications, depending on the type of multiple myeloma and the patient’s condition.
