Diflucan One (Fluconazole)

Diflucan One (fluconazole) is an antifungal medication belonging to a class of drugs called triazoles. It works by disrupting cell membranes to stop fungal growth. This prescription medication treats various yeast and fungal infections, including vaginal yeast infections, oral thrush, and more serious systemic fungal infections throughout the body.

Directions

Diflucan One is taken by mouth as a single dose for vaginal yeast infections. The standard dosage is 150 mg, which comes as one tablet or capsule swallowed whole with water, and can be taken with or without food at any time of day.

Take the medication exactly as prescribed. If symptoms don't improve within a few days or worsen, seek medical advice. While the single-dose treatment for vaginal yeast infections is convenient, it's important to complete any multi-day regimens fully even if symptoms improve earlier.

Ingredients

The active ingredient in Diflucan One is fluconazole.

Cautions

Before using this medication, you may want to consult a healthcare provider about the following:

• Any existing health conditions
• Any allergies
• A list of all medications currently being taken

Single-dose treatment only. Diflucan One is designed to be taken as a single oral dose for vaginal yeast infections.

Heart rhythm problems are rare but possible. Fluconazole may affect the heart’s electrical rhythm (QT prolongation) in rare cases, especially in people with heart disease, electrolyte imbalances, or certain medications.

Rare cases of serious liver injury have been reported with fluconazole, mainly in people with other serious health conditions. Contact your healthcare provider if you develop symptoms such as yellowing of the skin or eyes, dark urine, or unusual fatigue.

Severe skin reactions are very rare. In rare cases, fluconazole has been linked to serious skin reactions like Stevens-Johnson syndrome. Seek medical care if you develop blistering, peeling skin, or a widespread rash.

Drug interactions may occur. Diflucan One can interact with certain medications, including some heart medicines and hormonal birth control, so tell your healthcare provider about all medicines you take.

Pregnancy requires caution. Fluconazole should generally not be used during pregnancy unless a healthcare provider determines the benefits outweigh the risks.

Breastfeeding is not recommended. Fluconazole passes into breast milk, so healthcare providers usually recommend avoiding use while nursing.

Diflucan One should not be used in girls under 12 years old unless advised by a healthcare provider.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Known hypersensitivity to fluconazole or any ingredients in the formulation
• Allergy to other azole antifungal medications where cross-sensitivity may occur
• Concurrent use of terfenadine in patients receiving multiple fluconazole doses of 400 mg per day or higher
• Use with drugs that are known to prolong QT interval and are metabolized by CYP3A4 enzymes, such as cisapride, astemizole, erythromycin, pimozide, or quinidine

Side Effects

Common side effects of Diflucan One include:

• Headache
• Nausea
• Stomach or abdominal pain
• Diarrhea

These side effects were reported in clinical studies of people taking a single 150 mg dose for vaginal yeast infections. Most reactions are mild to moderate and usually go away on their own. Some people may also notice dizziness, indigestion, or a temporary change in taste.

More serious side effects are rare but possible. Diflucan can cause allergic reactions such as itching, hives, swelling of the face, lips, or throat, and difficulty breathing. In rare cases, it may lead to liver problems, severe skin reactions, irregular heart rhythms, or seizures. Contact your healthcare provider if you develop severe rash, yellowing of the skin or eyes, unusual fatigue, or swelling of the face or throat.