DuoCort (Hydrocortisone)
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Description
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Fact Table
| Fact Table | |
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| Formula | C21H30O5 |
| License | Approved (EMA approved; not FDA approved) |
| Bioavailability | ~96% |
| Legal status | Prescription Drug |
| Chemical Name | (11ß)-11,17,21-Trihydroxypregn-4-ene-3,20-dione |
| Elimination half-life | ~1.5–2 hours |
| Dosage (Strength) | 5mg, 10mg, 20mg modified-release tablets |
| Pregnancy | Use with caution; consult doctor |
| Brands | DuoCort, Plenadren |
| Protein binding | ~90% (bound to corticosteroid-binding globulin and albumin) |
| PubChem CID | 5754 |
| MedlinePlus | a682206 |
| ChEBI | 17650 |
| ATC code | H02AB09 |
| DrugBank | DB00741 |
| KEGG | D00086 |
| Routes of administration | By mouth |
Duocort is an adrenal insufficiency treatment medication that is prescribed for people with underactive adrenal glands and with hydrocortisone uses for fatigue, hyponatremia, nausea, and vomiting because of the condition. This medication contains a modified-release version of the corticosteroid that improves the person’s metabolic status and allows for better treatment outcomes with Addison’s disease treatment. You can buy DuoCort with a prescription here at Canpharm.
Directions
Standard dosage is to take Hydrocortisone 5mg 1x daily but dosage and frequency may vary and you should always take medication exactly as indicated in your prescription
Ingredients
The active ingredient in DuoCort is Hydrocortisone
Cautions
Let your doctor know of any history of heart problems, cataracts, glaucoma, high blood pressure, liver or kidney disease, diabetes, thyroid dysfunction, ulcers, diverticulitis, blood clots, low blood potassium or calcium, seizures, or pheochromocytoma (adrenal gland tumor) before starting on DuoCort
Use of this medication may cause stomach and excessive alcohol consumption can worsen it
Long-term use of corticosteroids like hydrocortisone can lower your body's ability to respond to stress or slow growth in children
Use of this medication may increase your risk of an infection or make existing infections worse. Avoid anyone who has an infection that may be spread easily, with examples being chickenpox, COVID-19, measles, and flu.
Older adults may be more susceptible to side effects from this medication
Women who are pregnant or breastfeeding should only use this medication if a doctor approves it
Interactions
Negative drug interactions may occur between DuoCort and other Rx or OTC medications, including aldesleukin, desmopressin, mifeprostine, clopidogrel, dabigatran, and warfarin. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy DuoCort online.
Side Effects
DuoCort side effects may occur, and some users may experience nausea, heartburn, headache, sleeping difficulties, increased sweating, or acne. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss Addison’s disease treatment alternatives.
Frequently Asked Questions about DuoCort (Hydrocortisone)
What is DuoCort used for?
DuoCort (hydrocortisone) is used to treat conditions associated with inflammation, such as adrenal insufficiency, certain skin conditions, and inflammatory disorders like arthritis.
How does DuoCort work?
DuoCort works by mimicking the effects of natural corticosteroids produced by the adrenal glands, which help reduce inflammation and regulate immune responses.
How should DuoCort be taken?
DuoCort is typically taken orally as prescribed, with the dosage and frequency depending on the condition being treated. It may also be available in injectable forms or topical applications depending on your doctor’s recommendation.
What are the side effects of DuoCort?
Common side effects include weight gain, increased blood sugar, stomach upset, mood swings, and fluid retention. Long-term use can increase the risk of osteoporosis, infections, and adrenal suppression.
How long does it take for DuoCort to work?
DuoCort begins to reduce inflammation and symptoms of adrenal insufficiency within a few hours to a day, but it may take several days to notice full symptom relief.
Who should not take DuoCort?
DuoCort should not be used by individuals with systemic fungal infections, certain viral infections, or those who are allergic to hydrocortisone or other corticosteroids.
Can DuoCort interact with other medications?
Yes, DuoCort can interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, and certain vaccines. Always inform your doctor about all the medications you are taking.
Can DuoCort cause weight gain?
Yes, weight gain due to fluid retention is a common side effect, especially with long-term use.
How should DuoCort be stored?
Store DuoCort at room temperature, away from light, moisture, and heat. Keep it out of the reach of children.
Can I stop taking DuoCort suddenly?
No, stopping DuoCort suddenly can lead to withdrawal symptoms and worsening of your condition. Always follow your doctor’s instructions when reducing or discontinuing this medication.
