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Fact Table
| Fact Table | |
|---|---|
| Formula |
Azelastine: C22H24ClN3O Fluticasone: C25H31F3O5S |
| License | FDA approved |
| Bioavailability |
Azelastine: ~40% (intranasal) Fluticasone: <1% (intranasal, minimal systemic absorption) |
| Legal status | Prescription Drug |
| Chemical Name |
Azelastine: 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Fluticasone: S-(fluoromethyl)6a,9-difluoro-11ß-hydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17ß-carbothioate |
| Elimination half-life |
Azelastine: ~22 hours Fluticasone: ~7.8 hours |
| Dosage (Strength) | 137 mcg Azelastine / 50 mcg Fluticasone per spray |
| Pregnancy | Use with caution; consult doctor |
| Brands | Dymista |
| Protein binding |
Azelastine: ~80–90% Fluticasone: ~91% |
| PubChem CID |
Azelastine: 2267 Fluticasone: 5311101 |
| MedlinePlus | a614030 |
| ChEBI |
Azelastine: 2958 Fluticasone: 53157 |
| ATC code | R01AD58 |
| DrugBank |
Azelastine: DB00938 Fluticasone: DB13867 |
| KEGG |
Azelastine: D07445 Fluticasone: D07907 |
| Routes of administration | Intranasal |
Dymista is a seasonal allergy treatment medication that is administered as a nasal spray for allergic rhinitis relief. Azelestine is an antihistamine that will block the production of the histamines required to cause allergy symptoms in the sinuses and Fluticasone is a corticosteroid that will suppress inflammation and swelling in the nasal passages. You can buy Dymista nasal spray with a prescription here at Canpharm.
Directions
Standard dosage for Dymista is to administer spray into both nostrils 2x a day as needed
Ingredients
The active ingredient in Dymista is Azelestine and Fluticasone
Cautions
Let your doctor know of any history of herpes, tuberculosis, cataracts, or glaucoma before starting on Dymista generic
Avoid anyone who has a viral infection while using this medication. Examples can be chickenpox, measles, flu, or COVID-19.
Long-term use of this medication may lower your body's ability to respond to physical stress or slow growth in children
Women who are pregnant or breastfeeding should only use this medication if their doctor approves it
Be aware of medication expiry date
Interactions
Negative drug interactions may occur between Dymista and other Rx or OTC medications, including albuterol, amlodipine, atorvastatin, diphenhydramine, cetirizine, cyclobenzaprine, doxycycline, gabapentin, levothyroxine, lisinopril, losartan, melatonin, meloxicam, metformin, montelukast, omeprazole, pantoprazole, prednisone, montelukast, budesonide, tramadol, and trazodone.
Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Dymista nasal spray online.
Side Effects
Dymista side effects may occur, and some users may experience nosebleeds, nose pain, eye pain, nasal dryness or irritation, taste changes, or sore throat. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss allergic rhinitis treatment medication alternatives and a pharmacist for a lower Dymista cost.
Frequently Asked Questions about Dymista
What is Dymista?
Dymista is a prescription nasal spray that combines azelastine (an antihistamine) and fluticasone (a corticosteroid). It is used to treat seasonal allergic rhinitis (hay fever) by reducing nasal congestion, sneezing, itching, and runny nose.
Can Dymista be used long-term?
Dymista is safe for long-term use if prescribed by a doctor. However, prolonged use of nasal steroids can increase the risk of side effects, so regular check-ups are recommended.
Can Dymista cause high blood pressure?
Dymista is not known to raise blood pressure significantly, but in rare cases, the fluticasone component may cause a slight increase in blood pressure, especially in people with pre-existing hypertension.
Can Dymista cause weight gain?
Weight gain is not a common side effect of Dymista. However, prolonged use of steroids (fluticasone) in high doses may contribute to fluid retention or metabolic changes.
Can you take Dymista while pregnant?
Dymista is classified as pregnancy category C, meaning there is limited research on its safety during pregnancy. Consult your doctor before using it while pregnant.
Does Dymista cause drowsiness?
Yes, Dymista can cause drowsiness due to its azelastine (antihistamine) component. It is best to avoid activities like driving if drowsiness occurs.
Does Dymista have steroids?
Yes, Dymista contains fluticasone, a corticosteroid that helps reduce inflammation and swelling in the nasal passages.
How does Dymista work?
Dymista works by combining:
- Azelastine (Antihistamine) – Blocks histamine to prevent allergy symptoms.
- Fluticasone (Steroid) – Reduces nasal inflammation and swelling.
This combination provides faster and stronger relief compared to using either ingredient alone.
How long does Dymista stay in your system?
- Azelastine: Has a half-life of about 22 hours, meaning it can stay in the body for up to 2–3 days.
- Fluticasone: Has a longer half-life, but due to its nasal application, it is mostly cleared within a few days after stopping use.
How long does Dymista take to work?
Dymista starts working within 30 minutes after use, but full effects may take a few days of regular use.
