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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Elonox, containing the active ingredient enoxaparin, is a low molecular weight heparin (LMWH) used predominantly for the prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also commonly prescribed for patients undergoing certain types of surgery to prevent blood clots and is used in the treatment of acute coronary syndrome (ACS), including heart attacks and unstable angina.
Enoxaparin works by inhibiting specific clotting factors in the blood, notably Factor Xa and IIa, which plays a crucial role in the blood clotting process. This action helps reduce the ability of blood to form clots. Unlike traditional heparin, enoxaparin has a more predictable response and does not typically require monitoring of blood clotting times, making it convenient for patient use in a non-hospital setting.
Before you buy Enoxaparin injection, it is crucial that you talk to your healthcare provider about potential side effects and Enoxaparin cost.
| Fact Table | |
|---|---|
| Formula | C26H40N2O36S5 |
| License | FDA approved |
| Bioavailability | 100% (Subcutaneous) |
| Legal status | Prescription Drugs |
| Chemical Name | Enoxaparin sodium |
| Elimination half-life | 4.5 hours (Subcutaneous) |
| Dosage (Strength) | 30 mg/0.3 mL, 40 mg/0.4 mL, 60 mg/0.6 mL |
| Pregnancy | Category B (Considered safe, but consult your doctor) |
| Brands | Lovenox, Clexane |
| Protein binding | < 10% |
| PubChem CID | 106040 |
| MedlinePlus | a601210 |
| ChEBI | 9127 |
| ATC code | B01AB05 |
| DrugBank | DB01225 |
| KEGG | D03696 |
| Routes of administration | Subcutaneous |
Elonox is administered via subcutaneous injection. It is crucial to follow your healthcare provider's instructions precisely.
For DVT Prophylaxis: Typically, 40 mg is administered once daily via subcutaneous injection. The duration of treatment may vary depending on the patient's risk factors and the type of surgery undergone.
For Treatment of Acute DVT or PE: The usual dose is 1 mg/kg administered twice daily or 1.5 mg/kg once daily by subcutaneous injection. Treatment duration is generally at least five days and until adequate anticoagulation is established.
For Acute Coronary Syndrome: For patients with unstable angina or non-Q-wave myocardial infarction, the recommended dose is 1 mg/kg administered subcutaneously every 12 hours in combination with oral antiplatelet therapy.
Always ensure the injection sites are rotated to avoid skin irritation, and do not inject into muscle tissue.
Active Ingredient: Enoxaparin sodium.
Elonox should be used with caution in patients with known allergies to heparin or pork products, as it may cause hypersensitivity reactions. Patients with kidney impairment, low body weight, or those at increased risk for bleeding should consult their healthcare provider as dose adjustments may be necessary.
Do not use enoxaparin sodium injection if you have:
Major bleeding
Thrombocytopenia (low platelet count) induced by heparin
An uncontrolled high blood pressure
Recent or upcoming surgery of the brain, spinal cord, or eye
Elonox can interact with various medications and increase the risk of bleeding. Therefore, it is crucial to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements. Key interactions include antiplatelet agents (e.g., aspirin, clopidogrel), nonsteroidal anti-inflammatory drugs (NSAIDs), other anticoagulants (e.g., warfarin, dabigatran) and selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
Common side effects of Elonox include:
What is Elonox?
Elonox, also known as Elonox HP, is a biosimilar biologic drug to Lovenox HP. It’s used to treat acute ST-segment Elevation Myocardial Infarction (STEMI), a particular form of heart attack.
What class of drug is enoxaparin?
Enoxaparin belongs to the class of medicines known as low molecular weight heparins (LMWH) and is an anticoagulant.
How to inject Elonox?
Elonox is administered by subcutaneous injection. The recommended dose is 1 mg/kg every 12 hours. Always choose a different injection site for each dose.
Why is enoxaparin a high-risk medication?
Enoxaparin can cause a serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), leading to long-term or permanent paralysis.
What is the most common side effect of enoxaparin?
The most common side effects of enoxaparin include bleeding, anemia, pain and bruising at the injection site, fever, and swelling in the legs.
What drugs should not be taken with enoxaparin?
Drugs that increase the risk of bleeding, such as NSAIDs (ibuprofen, Advil, Aleve, and others), should not be taken with enoxaparin.
How many days do you take enoxaparin for?
Enoxaparin is usually taken for at least 5 days and until a therapeutic oral anticoagulant effect has been achieved. The average duration is 7 days.
When should you not take enoxaparin?
You should not use enoxaparin if you are allergic to it, heparin, benzyl alcohol, or pork products, or if you have active or uncontrolled bleeding.
Does enoxaparin work immediately?
Yes, enoxaparin has an immediate onset of action.
What organ does enoxaparin affect?
Enoxaparin primarily affects the blood, preventing the formation of blood clots. It doesn’t specifically target an organ, but its effects are crucial for the heart and lungs.
Do you keep enoxaparin in the fridge?
The storage instructions for enoxaparin (Elonox) should be provided by the pharmacist or mentioned in the medication guide. Please refer to those instructions for accurate information.
