Eucrisa (Crisaborole)
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Fact Table
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| Formula | C14H10BNO3 |
| License | FDA approved (Initial U.S. approval: 2016) |
| Bioavailability | Not established for absolute systemic bioavailability after topical use |
| Legal status | Prescription only (Rx) |
| Chemical Name | 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile |
| Elimination half-life | Not well characterized for parent crisaborole after topical administration; rapidly metabolized to inactive metabolites |
| Dosage (Strength) | 2% topical ointment; apply a thin layer twice daily to affected areas |
| Pregnancy | Available data in pregnant women are insufficient to inform a drug-associated risk; use during pregnancy only if clearly needed |
| Brands | Eucrisa |
| Protein binding | Approximately 97% (in vitro, human plasma proteins) |
| PubChem CID | 44591583 |
| MedlinePlus | a617019 |
| ChEBI | 134677 |
| ATC code | D11AH06 |
| DrugBank | DB05219 |
| KEGG | D10873 |
| Routes of administration | Topical (ointment) |
Eucrisa (crisaborole) is a topical ointment used to treat mild to moderate atopic dermatitis (eczema) in adults and children 3 months of age and older. It works by blocking the PDE-4 enzyme, which helps reduce skin inflammation caused by eczema. Eucrisa contains 2% crisaborole in a white to off-white, petrolatum-based ointment that patients apply directly to affected areas of the skin.
Directions
Eucrisa should be applied as a thin layer to affected areas of skin twice daily, or as directed by a healthcare provider. It can be used on most areas of the body, including the face, but should not be applied in the eyes, mouth, or vagina. After applying the ointment, wash your hands unless you are treating the hands. Unlike some corticosteroid treatments, there are no specific limitations on how long Eucrisa can be used when directed by a healthcare provider.
Ingredients
The active ingredient in Eucrisa is crisaborole.
Cautions
Before using this medication, you may want to consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
Edarbyclor can harm an unborn baby, especially during the second or third trimester. If you become pregnant while taking this medication, stop using it and contact your healthcare provider right away.
Low blood pressure may occur when starting treatment. People who are dehydrated or taking strong diuretics may experience dizziness, lightheadedness, or fainting when starting Edarbyclor.
Kidney function may worsen in some patients. This medication can affect kidney function, particularly in people with existing kidney disease, heart failure, or narrowed kidney arteries. Your healthcare provider may monitor kidney function with blood tests.
Electrolyte imbalances are possible. Edarbyclor may change levels of important minerals such as potassium or sodium in the blood. Regular blood tests may be needed to monitor electrolyte levels.
Gout may be triggered in some people. One of the ingredients (chlorthalidone) can increase uric acid levels, which may lead to gout attacks in susceptible individuals.
Certain medications may increase side effects. Taking Edarbyclor with drugs that affect potassium levels or kidney function may increase the risk of complications, so inform your healthcare provider about all medications you take.
Contraindications
Avoid taking or using this medication if any of the following apply:
- Known hypersensitivity to crisaborole
- Known hypersensitivity to any ingredient of the formulation
Side Effects
Common side effects of Eucrisa include:
- Burning or stinging at the application site
- Mild skin irritation
These effects usually occur where the ointment is applied and are often temporary. The burning or stinging sensation may be more noticeable during the first few days of treatment. These symptoms typically improve as your skin adjusts to the medication.
More serious side effects are uncommon but possible. Some people may develop allergic reactions such as hives or allergic contact dermatitis. Symptoms may include severe itching, redness, swelling, or rash at the application site. Stop using Eucrisa and contact your healthcare provider if you notice signs of an allergic skin reaction.
Frequently Asked Questions about Eucrisa (Crisaborole)
What is Eucrisa (crisaborole) used for?
Eucrisa is a prescription ointment used on the skin to treat mild to moderate atopic dermatitis, also called eczema. It is approved for adults and children 3 months of age and older.
How does Eucrisa work?
Eucrisa is a phosphodiesterase-4 inhibitor. It helps reduce inflammation in the skin, which can improve symptoms such as itching, redness, and irritation linked to eczema.
How is Eucrisa usually applied?
Eucrisa is usually applied as a thin layer to the affected skin twice daily. Once a good clinical response is reached, some patients may be told to reduce use to once daily. It is for topical use only and should not be used in the eyes, mouth, or vagina.
Can Eucrisa be used in babies and children?
Yes. Eucrisa is approved for children as young as 3 months old. It is often considered a non-steroid prescription option for eczema in both children and adults.
What are the most common side effects of Eucrisa?
The most common side effect is application-site pain, which may feel like burning or stinging where the ointment is put on. This is usually mild and temporary, but some people find it bothersome.
Can Eucrisa cause an allergic reaction?
Yes. Although uncommon, Eucrisa can cause hypersensitivity reactions, including contact urticaria. Warning signs can include severe itching, swelling, redness, or rash at the application site or even at another area of the body. If that happens, the medicine should be stopped and medical help should be sought.
Is Eucrisa a steroid?
No. Eucrisa is not a corticosteroid. It is a non-steroidal topical treatment, which is one reason it may be chosen for certain patients who need a prescription eczema treatment without using a topical steroid.
How quickly does Eucrisa start working?
Some people notice improvement within the first few weeks, but response can vary. Eczema medicines often need consistent use, and it may take time for itching and inflamed patches to improve meaningfully.
Who should not use Eucrisa?
Eucrisa should not be used by anyone with a known allergy to crisaborole or any of its ingredients. People who develop significant irritation or signs of allergy while using it should stop it and be evaluated.
What should someone know before starting Eucrisa?
Eucrisa is meant for mild to moderate eczema and is applied only to affected skin. It is important to use it exactly as directed, avoid sensitive internal areas, and monitor for burning, stinging, or allergic-type reactions. For persistent, worsening, or widespread eczema, a clinician may need to reassess the treatment plan.
