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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Firdaspe, containing the active ingredient Amifampridine, is a prescription medication approved for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in adults. LEMS is a rare autoimmune disorder that affects the neuromuscular junction, causing muscle weakness. Amifampridine works by increasing the release of acetylcholine, a neurotransmitter essential for communication between nerves and muscles, thereby improving muscle strength and function. Amifampridine uses include treating certain neuromuscular disorders by enhancing nerve signal transmission to improve muscle strength.
Before you buy Amifampridine, it is crucial that you talk to your healthcare provider about potential side effects and Amifampridine cost.
| Fact Table | |
|---|---|
| Formula | C10H10N2 |
| License | FDA approved |
| Bioavailability | 90-100% |
| Legal status | Prescription drug |
| Chemical Name | Amifampridine |
| Elimination half-life | Approx. 2 hours |
| Dosage (Strength) | 10 mg tablets |
| Pregnancy | Consult your doctor |
| Brands | Firdapse |
| Protein binding | Not significantly bound |
| PubChem CID | 219024 |
| MedlinePlus | Not listed specifically for Firdapse |
| ChEBI | Not listed specifically for Amifampridine |
| ATC code | N07XX07 |
| DrugBank | DBSALT002201 (Amifampridine Phosphate) |
| KEGG | D10221 (Amifampridine Phosphate) |
| Routes of administration | Oral |
The starting dose of Firdaspe is typically 15 mg per day, divided into 3 to 4 doses. Based on individual response and tolerability, your healthcare provider may adjust this dose. The maximum recommended daily dose is 80 mg. Take Firdaspe tablets orally with water, with or without food. Space your doses evenly throughout the day to maintain steady levels of the medication in your blood.
Active Ingredient: Amifampridine phosphate.
Inform your doctor if you have any known allergies to amifampridine or any of the tablet's inactive ingredients.
Discuss your medical history with your healthcare provider, particularly if you have kidney disease, seizures, or liver problems.
The effects of Firdaspe during pregnancy and breastfeeding are not fully known. It is important to discuss the potential risks and benefits with your healthcare provider if you are pregnant, plan to become pregnant, or are breastfeeding.
Firdaspe can cause seizures. The risk may be higher at higher doses or in patients with a history of seizures.
Avoid driving or operating heavy machinery until you know how Firdaspe affects you, as it can cause dizziness or seizures.
Firdaspe can interact with other medications, which can alter how your medications work or increase your risk for serious side effects. Specific interactions include other drugs that increase the risk of seizures, cimetidine and aminopyridines.
Common side effects of Firdaspe include:
What is the drug FIRDAPSE used for?
FIRDAPSE (amifampridine) is used for the treatment of Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disorder that affects the connection between nerves and muscles, leading to muscle weakness.
Is FIRDAPSE an orphan drug?
Yes, FIRDAPSE is designated as an orphan drug. Orphan drugs are intended for the treatment, prevention, or diagnosis of rare diseases or conditions.
Is FIRDAPSE approved by the FDA?
Yes, FIRDAPSE is approved by the U.S. Food and Drug Administration (FDA). It received approval in November 2018 for the treatment of LEMS in adults.
What drugs interact with FIRDAPSE?
Several drugs can interact with FIRDAPSE, including:
What is the difference between FIRDAPSE and Ruzurgi?
Both FIRDAPSE and Ruzurgi contain the active ingredient amifampridine and are used to treat LEMS. The primary difference is that FIRDAPSE is approved for use in adults, while Ruzurgi is approved for use in pediatric patients aged 6 to less than 17 years.
What are the contraindications for FIRDAPSE?
FIRDAPSE is contraindicated in patients with:
What is the route of administration for FIRDAPSE?
FIRDAPSE is administered orally in tablet form.
Is FIRDAPSE approved by the EMA?
Yes, FIRDAPSE is approved by the European Medicines Agency (EMA) for the treatment of LEMS in adults.
What is the bioavailability of FIRDAPSE?
The bioavailability of FIRDAPSE (amifampridine) is high, typically around 93% following oral administration.
