Gemtesa (Vibegron)
Obgemsa
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Description
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Fact Table
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| Formula | C26H28N4O3S |
| License | FDA approved (2020); approved in Japan |
| Bioavailability | ~75% (oral) |
| Legal status | Prescription only (Rx) |
| Chemical Name | (1S)-3-(2-amino-1,3-thiazol-4-yl)-1-(4-fluorophenyl)-3,4-dihydroisoquinolin-2(1H)-one derivative |
| Elimination half-life | ~30 hours |
| Dosage (Strength) | 75 mg oral tablet (once daily) |
| Pregnancy | Limited human data – use only if benefit outweighs risk |
| Brands | Gemtesa |
| Protein binding | ~50% |
| PubChem CID | 11883515 |
| MedlinePlus | a621053 |
| ChEBI | 145646 |
| ATC code | G04BD12 |
| DrugBank | DB15605 |
| KEGG | D11775 |
| Routes of administration | By mouth (oral tablets) |
Gemtesa (vibegron) is a beta-3 adrenergic receptor agonist used to treat overactive bladder in adults. It works by relaxing the bladder muscle to help reduce sudden urges to urinate and decrease how often someone needs to use the bathroom. The medication is also approved for treating overactive bladder symptoms in men with benign prostatic hyperplasia (an enlarged prostate).
Directions
Take Gemtesa by mouth once daily with a full glass of water. The standard dosage is 75 mg, which comes as one tablet. You can take it with or without food at any time of day. Swallow the tablet whole and don't crush, chew, or break it. Try to take vibegron at around the same time every day to help remember your dose. If a dose is missed, take it as soon as you remember unless it's close to the time for the next scheduled dose. Don't take two doses at the same time to make up for a missed one.
Ingredients
The active ingredient in this drug is vibegron.
Cautions
- Before using this medication, you may want to consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
- Gemtesa can sometimes make it hard to fully empty your bladder. This risk may be higher if you already have a blockage or take other bladder medications, so contact your provider if you notice weak urine flow, difficulty starting, or feeling unable to empty your bladder.
- Rarely, Gemtesa can cause sudden swelling of the face, lips, tongue, or throat, which can be dangerous. Stop taking Gemtesa and get emergency medical help right away if you have swelling or trouble breathing.
Contraindications
Avoid taking or using this medication if any of the following apply:
- Known hypersensitivity to vibegron
- Severe allergic reactions to any inactive ingredients in the tablets
Side Effects
Common side effects of Gemtesa include:
- Urinary tract infection
- Nasal congestion, sore throat, or runny nose
- Headache
- Nausea
- Diarrhea
- Upper respiratory tract infection
These side effects are generally mild and often improve as your body adjusts to the medication. Let your healthcare provider know if any symptoms are persistent or bothersome.
More serious side effects can occur, including urinary retention (difficulty emptying the bladder) and angioedema, a rare but potentially life-threatening allergic reaction that causes swelling of the face, lips, tongue, or throat. Stop taking Gemtesa and seek emergency care if you have trouble breathing, swelling of the mouth or throat, or an inability to urinate.
Frequently Asked Questions about Gemtesa (Vibegron)
What is Gemtesa used for?
Gemtesa (vibegron) is a prescription medication used to treat overactive bladder (OAB) in adults. It helps manage symptoms such as urinary urgency, frequent urination, and urge urinary incontinence.
How does Gemtesa work?
Gemtesa is a beta-3 adrenergic receptor agonist. It works by relaxing the bladder muscle (detrusor), allowing the bladder to hold more urine and reducing the strong urge to urinate.
How should I take Gemtesa?
Gemtesa is taken orally, usually once daily with or without food. It should be swallowed whole and not crushed or chewed. Follow your healthcare provider’s instructions on dosage and timing.
What are the common side effects of Gemtesa?
The most commonly reported side effects include headache, diarrhea, nausea, and upper respiratory tract infections. Some people may also experience elevated blood pressure or urinary tract infections.
Is Gemtesa different from other overactive bladder medications?
Yes, unlike anticholinergic drugs used for OAB, Gemtesa does not block acetylcholine and generally causes fewer side effects like dry mouth or constipation. It offers a non-anticholinergic treatment option for OAB.
Can Gemtesa be taken with other medications?
Gemtesa may interact with certain medications, especially those that affect liver enzymes (CYP3A), or digoxin. Always inform your healthcare provider about all medicines, supplements, or herbal products you’re taking.
Who should not take Gemtesa?
Gemtesa is not recommended for individuals with severe liver or kidney problems unless advised by a healthcare provider. Safety and effectiveness have not been established in children under 18.
How long does it take for Gemtesa to start working?
Some people may notice improvement in bladder symptoms within the first few weeks, but full benefits may take up to 8 weeks. Continued daily use is important for best results.
Can I stop taking Gemtesa if my symptoms improve?
Do not stop taking Gemtesa without consulting your healthcare provider. Symptoms of overactive bladder may return if the medication is discontinued.
Is Gemtesa safe for long-term use?
Clinical studies have shown Gemtesa to be safe and effective for long-term use in managing overactive bladder. Regular check-ins with your healthcare provider are recommended to monitor progress and any side effects.
