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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lenvima is a kinase inhibitor used to treat certain types of cancer. Kinase inhibitors are enzyme inhibitors that blocks the action of one or more protein kinases which interferes with the growth and spread of cancer cells in the body. Lenvima is used to treat thyroid cancer. It is usually given after radioactive iodine has been tried without success. Lenvima is used together with everolimus (Afinitor) to treat advanced kidney cancer in people who have received one treatment course with another cancer medicine. Lenvima is used together with pembrolizumab (Keytruda) to treat advanced kidney cancer that has spread to other parts of the body (metastatic), or cannot be removed with surgery. Lenvima is also used together with Keytruda to treat a certain type of endometrial cancer (a type of uterine cancer) that has progressed and cannot be removed with surgery or radiation. Lenvima is also used to treat liver cancer that cannot be removed with surgery.
Take Lenvima exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Take Lenvima at the same time each day, with or without food. To get a full dose, you may need to take a combination of capsules with different amounts (strengths) of lenvatinib in them. Follow your doctor's dosing instructions very carefully. Swallow the capsule whole and do not crush, chew, break, or open it. If you cannot swallow a capsule whole, dissolve the capsules in water as follows: • Measure 1 tablespoon of water or apple juice and pour the liquid into a small glass. • Place only enough capsules for one dose into the liquid. Allow the capsules to dissolve for at least 10 minutes, then stir the mixture for at least 3 more minutes. • Drink this mixture right away. Add a little more water or juice to the glass, swirl gently and drink right away. Call your doctor if you are sick with vomiting or severe diarrhea. Prolonged illness can lead to dehydration and kidney failure. Drink plenty of liquids if you have diarrhea. Carefully follow your doctor's instructions about when to start taking medicine to prevent diarrhea while you are using Lenvima. You will need frequent medical tests and blood pressure checks. Pay special attention to your dental hygiene while taking Lenvima. Brush and floss your teeth regularly. If you need to have any dental work or surgery, tell the dentist or doctor ahead of time that you are using Lenvima. Store at room temperature away from moisture and heat.
The active ingredient in Lenvima is lenvatinib.
Some people taking Lenvima have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Get emergency medical help if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink. Call your doctor at once if you have signs of serious side effects, including: severe chest pain, shortness of breath, swelling in your ankles, numbness or weakness, confusion, severe headache, problems with speech or vision, seizure (convulsions), unusual bleeding, coughing up blood, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Some people taking Lenvima have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink. Also call your doctor at once if you have: • severe diarrhea; • headache, confusion, weakness, vision loss, seizure (convulsions); • pain or burning when you urinate, urinating less; • unusual bleeding (nosebleeds, heavy menstrual bleeding), or any other bleeding that will not stop; • severe headache, blurred vision, pounding in your neck or ears; • jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work; • signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; • heart problems - chest pain, pain in your jaw or shoulder, swelling in your lower legs, feeling short of breath; • signs of a blood clot - sudden numbness or weakness, pain in your arms or back, problems with vision or speech; • liver problems - dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); • low calcium level - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common Lenvima side effects may include: • bleeding; • stomach pain, nausea, vomiting, diarrhea, constipation; • loss of appetite, weight loss; • abnormal urine tests or thyroid function tests, increased blood pressure; • muscle or joint pain; • swelling in your arms and legs; • mouth sores; • rash; • redness, itching, or peeling skin on your hands or feet; • headache, tiredness; or • cough, trouble breathing, hoarse voice. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.