Linzess (Linaclotide)

Linzess (linaclotide) is a prescription medicine used to treat constipation-related bowel problems. It is approved for adults with irritable bowel syndrome with constipation (IBS-C) or chronic constipation, and for children and teens ages 6 to 17 with functional constipation. Linzess works by increasing fluid in the intestines, which softens stools, makes bowel movements easier, and helps reduce stomach pain linked to IBS-C.

Directions

Take Linzess on an empty stomach at least 30 minutes before the first meal of the day. Swallow the capsule whole with water. Don't break, chew, or open it. Take the medication at around the same time each day.

Standard dosing varies by condition:

• Irritable bowel syndrome with constipation: 290 mcg once daily for adults
• Chronic idiopathic constipation: 145 mcg once daily for adults, though 72 mcg may be used based on tolerability
• Functional constipation: Dosage ranges from 72 mcg to 145 mcg once daily, depending on age and weight

For those with trouble swallowing capsules, the capsule can be opened and the contents mixed with applesauce or water. When mixing with applesauce, use 1 teaspoon and swallow it immediately without chewing. When mixing with water, add the contents to approximately 1 ounce of room temperature water, gently swirl for at least 20 seconds, and drink the mixture. It may be recommended to add another ounce of water to the cup, swirl it, and drink it to ensure the full dose is taken.

Linzess should be taken exactly as directed without adjusting the dose unless a healthcare provider recommends it. Store the capsules at room temperature in their original container with the desiccant inside to protect them from moisture.

Ingredients

Linzess contains linaclotide as its active ingredient.

Cautions

• Before using this medication, you may want to consult a healthcare provider about the following:
  • Any existing health conditions
  • Any allergies
  • A list of all medications currently being taken
• Linzess should not be used in children under 2 years old because it can cause severe diarrhea and dangerous dehydration, which has been linked to serious harm in very young children.
• Diarrhea is the most common side effect of Linzess in adults and children, and it can sometimes be severe, especially at higher doses.
• In rare cases, severe diarrhea has led to dehydration, dizziness, fainting, low blood pressure, or electrolyte problems that required hospitalization or IV fluids.
• If severe diarrhea happens, Linzess should be stopped right away and fluids should be replaced to prevent dehydration.

Contraindications

Avoid taking or using this medication if any of the following apply:

• Age under 2 years
• Known or suspected mechanical gastrointestinal obstruction

Side Effects

Common side effects of Linzess include:

• Diarrhea
• Gas
• Stomach or abdominal pain
• Abdominal swelling, fullness, or pressure (distention)

Diarrhea is the most common side effect and often starts within the first two weeks of treatment. While it is usually manageable, it can sometimes be severe. Stop taking Linzess and contact your healthcare provider if you develop severe or persistent diarrhea.

More serious symptoms need urgent medical attention. Call your healthcare provider or go to the emergency room if you have severe or unusual abdominal pain, especially if it occurs with bright red blood in the stool or black, tar-like stools.