Ludiomil (Maprotiline)
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Description
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Fact Table
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| Formula | C20H23N |
| License | Approved in Europe and other regions (1970s); not FDA approved |
| Bioavailability | ~60–70% (oral) |
| Legal status | Prescription only (Rx) |
| Chemical Name | 3-(9,10-dihydro-9,10-ethanoanthracen-9-yl)-N-methylpropan-1-amine |
| Elimination half-life | ~40–60 hours |
| Dosage (Strength) | 25 mg tablets; usual daily dose 75–150 mg in divided doses or once daily |
| Pregnancy | Category C – Use only if benefit outweighs risk |
| Brands | Ludiomil, generics available |
| Protein binding | ~88–90% |
| PubChem CID | 4013 |
| MedlinePlus | Not assigned |
| ChEBI | 6825 |
| ATC code | N06AA21 |
| DrugBank | DB00602 |
| KEGG | D08369 |
| Routes of administration | By mouth (oral tablets) |
Ludiomil (maprotiline) is a medication used to help treat depression. It is sometimes prescribed when anxiety occurs alongside depressive symptoms. As a tetracyclic antidepressant, it works by increasing the level of a natural brain chemical called norepinephrine. Ludiomil is taken by mouth as an oral tablet to help manage mood and emotional balance.
Directions
Take maprotiline at the same time each day, with or without food. Swallow the tablets whole with water.
Adults usually start at about 75 mg per day. A doctor may slowly increase the dose based on how well it works and how well it's tolerated. Most people need around 150 mg per day for depression. Some may need up to 225 mg per day, taken in divided doses or as a single dose at bedtime. People with severe depression in the hospital may receive higher doses with close monitoring.
Older adults usually start at a lower dose, often around 25 mg per day. It can take 2 to 4 weeks to notice improvement. Doctors may adjust the dose gradually to find what works best, then lower it to the smallest dose that keeps symptoms under control.
Do not stop taking maprotiline or change your dose without talking to your healthcare provider.
Ingredients
The active ingredient in Ludiomil is maprotiline.
Cautions
- Before using this medication, you may want to consult a healthcare provider about the following:
- Any existing health conditions
- Any allergies
- A list of all medications currently being taken
- Ludiomil may increase the risk of suicidal thoughts or behavior, especially in children, teens, and young adults during the first few months of treatment or when the dose changes.
- Some people may notice new or worsening symptoms such as anxiety, agitation, restlessness, trouble sleeping, irritability, impulsive behavior, or mood swings. If these symptoms are severe, appear suddenly, or were not there before treatment, contact a healthcare provider.
- Ludiomil can trigger manic or hypomanic episodes in people who have or may have bipolar disorder. Screening for bipolar disorder before starting treatment is important.
- Seizures have been reported with Ludiomil, even in people without a seizure history, especially at higher doses or with rapid dose increases.
- This medication should be used with caution in people with heart disease, including past heart attacks or heart rhythm problems, as it can affect heart conduction and heart rate.
- Ludiomil can cause drowsiness, slowed reaction time, or impaired judgment, so you should be careful with driving or operating machinery until you know how it affects you. Stopping the medication without gradually decreasing the dose may cause withdrawal-like symptoms.
- Family members and caregivers should watch for mood or behavior changes and report any concerning symptoms. Prescriptions are often written for smaller quantities to reduce the risk of overdose.
Avoid taking or using this medication if any of the following apply:
- Currently taking or recently stopped (within 14 days) a monoamine oxidase inhibitor (MAOI)
- Known hypersensitivity or allergy to maprotiline or any ingredients in the tablets
- Recent heart attack (acute recovery period of myocardial infarction)
- History of seizure disorder or epilepsy
Side Effects
Common side effects of Ludiomil include:
- Drowsiness or sleepiness
- Dizziness or lightheadedness
- Dry mouth
- Constipation
- Blurred vision
- Headache
- Fatigue or weakness
- Nausea or stomach upset
- Nervousness, anxiety, or agitation
These side effects are similar to those seen with other tricyclic-type antidepressants and are often dose related. Let your healthcare provider know if these symptoms persist or worsen.
More serious side effects can affect the heart, nervous system, or mood. These may include heart rhythm problems, fainting, seizures, confusion or hallucinations (especially in older adults), and worsening depression or suicidal thoughts, particularly when starting treatment or changing doses. Contact a healthcare provider or seek immediate medical help if you experience chest pain, severe mood or behavior changes, seizures, or a widespread rash with blistering.
Frequently Asked Questions about Ludiomil (Maprotiline)
What is Ludiomil (Maprotiline) used for?
Ludiomil (maprotiline) is primarily used to treat depression, especially when symptoms include anxiety or agitation. It belongs to a class of antidepressants called tetracyclic antidepressants and works by restoring the balance of neurotransmitters in the brain, mainly norepinephrine.
How does Maprotiline work?
Maprotiline works by inhibiting the reuptake of norepinephrine, a neurotransmitter involved in mood regulation. This increases the concentration of norepinephrine in the brain, which can help improve mood and reduce depressive symptoms.
How should Ludiomil be taken?
Ludiomil is usually taken by mouth once daily, preferably in the evening to minimize daytime drowsiness. It should be taken exactly as prescribed by a healthcare provider, and doses should not be increased or decreased without medical supervision.
What are the common side effects of Maprotiline?
Common side effects include drowsiness, dry mouth, dizziness, constipation, blurred vision, and weight gain. These effects are generally mild, but if they persist or worsen, medical attention may be needed.
Can Ludiomil cause serious side effects?
Yes, serious side effects can occur, such as seizures, irregular heartbeat, severe allergic reactions, or worsening depression and suicidal thoughts, especially when starting the medication or adjusting the dose. Immediate medical help should be sought if any of these occur.
Who should not take Maprotiline?
Maprotiline should not be used by individuals with a history of seizures, recent heart attack, or certain heart rhythm disorders. It is also not recommended for patients with glaucoma or urinary retention unless closely monitored.
Is Ludiomil habit-forming or addictive?
Ludiomil is not considered habit-forming or addictive. However, it should not be stopped abruptly without consulting a healthcare provider, as this can lead to withdrawal symptoms or worsening depression.
How long does it take for Maprotiline to work?
It may take 2 to 4 weeks to notice significant improvements in mood and energy levels. Some symptoms like anxiety or sleep problems may improve sooner, but full therapeutic effects typically take several weeks.
Can Ludiomil be taken with other medications?
Ludiomil can interact with other medications, including MAO inhibitors, anticholinergic drugs, and other central nervous system depressants. Always inform your healthcare provider about all medications and supplements being taken.
Is Ludiomil safe during pregnancy or breastfeeding?
The safety of Ludiomil during pregnancy or breastfeeding has not been fully established. It should only be used if the potential benefits outweigh the risks. A healthcare provider should be consulted before using this medication in these situations.
