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Lupron (Leuprolide) Depot

Also Known as Lucrin,Lucrin

Prescription requiredOnly Available By Prescription
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


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Lupron Depot is an endometriosis treatment medication for women, available by prescription. It is also used in the treatment of uterine fibroids. Another use case is as a palliative treatment for advanced prostate cancer in men. Leuprolide Acetate, a GnRH agonist drug, blocks the production of hormones in the body, which are essential for the growth of cells promoting endometriosis or uterine fibroids. For prostate cancer treatment, Lupron Depot inhibits testosterone production. Buy Lupron Depot from Canada and Canpharm to get the best price.

Fact Table
Formula C59H84N16O12
License US FDA, US DailyMed, EU EMA
Bioavailability 4% to 18%
Legal status Prescription drug
Chemical Name Leuprorelin
Elimination half-life 3 hours
Dosage (Strength) 3.75mg, 7.5mg, 11.25mg, 22.5mg, 30mg
Pregnancy Consult a doctor
Brands Lupron Depot
Protein binding 43% and 49%
PubChem CID 657181
MedlinePlus a685040
ChEBI Not Assigned
ATC code L02AE02
DrugBank DB00007
KEGG D08113
Routes of administration implant, subcutaneous, intramuscular

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Lupron Depot injections should only be administered by a physician in a clinical environment. The Lupron Depot 3-month dosing schedule applies only to endometriosis treatment or for limiting the growth of uterine fibroids.

Endometriosis/Uterine Fibroids: Injection given every 3 months, or once each month based on the doctor's determination.

Advanced Prostate Cancer Treatment: Injection given at 1-month , 3-month , 4-month , or 6-month intervals based on the treatment plan laid out by the doctor.


The active ingredient in Lupron Depot is Leuprolide Acetate.


Inform your doctor of any history of heart disease, poor cardiac health, or osteoporosis (bone density loss) before starting Lupron Depot.

Using Lupron Depot may reduce fertility in both men and women.

It is recommended to drink alcohol in moderation or not at all while taking Lupron Depot.

Be aware of the medication's expiry date.


Negative drug interactions may occur between Lupron Depot and other Rx medications, including albuterol, amlodipine, atorvastatin, bupropion, bicalutamide, clonazepam, cyclobenzaprine, furosemide, gabapentin, hydrochlorothiazide, levothyroxine, lisinopril, losartan, metformin, omeprazole, ondansetron, oxycodone, pantoprazole, prednisone, tamsulosin, tramadol, trazodone, and abiraterone.

Inform your doctor of all medications you are currently taking before getting a prescription and proceeding to buy Lupron Depot online.

Side Effects

Lupron Depot side effects may occur. Some users may experience acne, abdominal pain, diarrhea, loss of sex drive, breast tenderness, headache, hot flashes, increased sweating, injection site reactions, mood changes, rash, or weight gain. If side effects are experienced, consider stopping use and meeting with a doctor again to discuss alternative endometriosis treatment medications.

Frequently Asked Questions about Lupron Depot (Leuprolide Acetate for Depot Suspension)

What is Lupron Depot used for?

Lupron Depot (leuprolide acetate for depot suspension) is used for the treatment of advanced prostate cancer and central precocious puberty (CPP) in children. It is also used for the management of endometriosis and before fibroid surgery to improve anemia due to vaginal bleeding from fibroids.

How is Lupron Depot administered?

Lupron Depot is administered as an injection into the muscle by a healthcare provider, either monthly, every 3 months, 4 months, or 6 months, depending on the condition being treated.

What are the common side effects of Lupron Depot?

Common side effects include hot flashes/sweats, injection site reactions, general pain, swelling, testicular shrinkage, difficulty urinating, fatigue, headache, joint, gastrointestinal, and respiratory problems. Children treated for CPP may experience increased signs of puberty during the first few weeks.

Are there any serious risks associated with Lupron Depot?

Lupron Depot can increase the risk of heart attack, sudden death, stroke, and can affect the electrical activity of the heart. It may also cause high blood sugar, increased risk of diabetes, high lipids, and liver fat accumulation. It's important to discuss these risks with your doctor.

Can Lupron Depot be used during pregnancy?

Lupron Depot may cause fetal harm if administered to a pregnant woman. It is advised not to use this medication if you are pregnant or planning to become pregnant.

Is it safe to breastfeed while using Lupron Depot?

It is not known if Lupron Depot passes into breast milk. You should discuss the risks of breastfeeding while using this medication with your doctor.

Can Lupron Depot interact with other medications?

Yes, Lupron Depot can interact with various medications, including those used for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Always inform your doctor about all the medications you are taking.

What should I do if I miss a dose of Lupron Depot?

If you miss a dose, contact your doctor to find out what to do. It's important to keep all scheduled appointments for injections to ensure the effectiveness of the treatment.

Are there any restrictions regarding food, alcohol, or tobacco while using Lupron Depot?

Certain medicines, including Lupron Depot, should not be used around the time of eating certain types of food or consuming alcohol or tobacco as interactions may occur. Discuss this with your healthcare professional.

What should I do if I experience severe side effects or allergic reactions to Lupron Depot?

If you experience signs of an allergic reaction, high blood sugar, infection, high blood pressure, dehydration, or severe bone pain, seek medical help immediately.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.