Migranal Nasal Spray (Dihydroergotamine)

Prescription Required
Brand
Dose Size & Price Qty
4mg / ml (3 x 1ml)
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Fact Table

Fact Table
Formula C33H37N5O5
License FDA approved
Bioavailability ~32% (nasal spray)
Legal status Prescription Drug
Chemical Name (6aR,9R,10aR)-N-[(Hydroxyacetyl)-1-methylpropyl]-6a,10a-dihydro-12'-hydroxy-2',5',9-trimethyl-ergotaman-3',6',18-trione
Elimination half-life ~10 hours
Dosage (Strength) 4mg/mL solution (1mg per spray)
Pregnancy Contraindicated (Category X)
Brands Migranal
Protein binding ~93%
PubChem CID 441260
MedlinePlus a604028
ChEBI 4652
ATC code N02CA01
DrugBank DB00320
KEGG D07876
Routes of administration Intranasal

Migranal nasal spray is a migraine treatment medication that is administered as a mist that goes directly into the sinus for fast-acting migraine relief. It can be used by both people with standard migraines or those who get them with aura. Dihydroergotamine is an ergot alkaloid drug that targets serotonin receptors in the brain and the shrinking of blood vessels that results from it reduces the severity of migraine headaches and makes them less painful. You can buy Migranal nasal spray with a prescription here at Canpharm.

Directions

Standard Migranal nasal spray dosage is to administer 1 dose of the spray as needed at the onset of a migraine headache

Administration:

  • Prime nasal pump
  • Insert applicator tip into either nostril, ensuring that there is no nasal blockage due to mucus buildup before delivering the dose
  • Use index and middle fingers to press down on activator handle to administer one dose of the medicated spray
  • Inhale strongly through nose with opposite nostril closed to ensure all of the dose is administered

Ingredients

The active ingredient in Migranal nasal spray in Dihydroergotamine

Cautions

This medication is for nasal injection only and it should not be ingested in any other way

Do not give yourself more than 3 inhalations in a 24-hour period

Let your doctor know of any history of liver or kidney problems, poor heart health, high cholesterol, diabetes, peripheral vascular disease, Raynaud's syndrome, or hemiplegic or basilar headaches before starting with Migranal nasal spray

Woman who are pregnant should not use this medication because the risk of preterm labor and women who are breastfeeding should refrain from it for 3 days after administering a dose of this migraine nasal spray

Store at room temperature and away from moisture, heat, and light

Be aware of medication expiry date

Interactions

Negative drugs interactions may occur between Migranal nasal spray and other Rx or OTC medications, including duloxetine, venlafaxine, cyclobenzaprine, sumatriptan, rizatriptan, eletriptan, montelukast, and ondansetron. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Migranal nasal spray online.

Side Effects

Migranal side effects may occur, and some users may experience runny or stuffy nose, nausea, vomiting, diarrhea, taste changes, localized irritation, dizziness, drowsiness, or sore throat. If side effects are seen you may want to meet a doctor to discuss migraine headache emergency relief medication alternatives and a pharmacist for a lower Migranal nasal spray price.

Frequently Asked Questions about Migranal Nasal Spray (Dihydroergotamine)


What is Migranal Nasal Spray used for?

Migranal Nasal Spray (dihydroergotamine) is used to treat acute migraine headaches with or without aura.


How does Migranal Nasal Spray work?

Migranal works by constricting blood vessels in the brain and reducing inflammation, which helps alleviate migraine pain and symptoms.


How should Migranal Nasal Spray be used?

Migranal Nasal Spray is typically sprayed into one nostril at the onset of a migraine. If needed, a second dose can be taken after 1 hour, as directed by your doctor.


What are the side effects of Migranal Nasal Spray?

Common side effects include nasal irritation, dizziness, nausea, and a sensation of tightness in the chest. Serious side effects may include high blood pressure, heart issues, or severe allergic reactions.


How long does it take for Migranal Nasal Spray to work?

Migranal typically starts working within 15 to 30 minutes to relieve migraine pain, although complete relief may take up to 2 hours.


Who should not use Migranal Nasal Spray?

Migranal should not be used by individuals with a history of heart disease, high blood pressure, or peripheral vascular disease, or those who are pregnant.


Can Migranal Nasal Spray interact with other medications?

Yes, Migranal can interact with other medications, especially other migraine treatments, triptans, or ergot-related medications. Inform your doctor of all other medications you are taking.


Can Migranal Nasal Spray cause rebound headaches?

Yes, frequent use of Migranal may lead to medication overuse headaches, where migraines worsen or become more frequent.


How should Migranal Nasal Spray be stored?

Store Migranal Nasal Spray at room temperature, away from heat and moisture, and keep the bottle tightly closed.


Can I stop using Migranal Nasal Spray suddenly?

Migranal Nasal Spray is used as needed for acute migraines, so there is no need to stop it suddenly. However, it should be used only as prescribed to avoid overuse and complications.

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